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Volumn 265, Issue 3, 2015, Pages 219-226

1H-magnetic resonance spectroscopy in obsessive–compulsive disorder: effects of 12 weeks of sertraline treatment on brain metabolites

Author keywords

Magnetic resonance spectroscopy; N acetylaspartate; Neuroimaging; Obsessive compulsive disorder; Sertraline

Indexed keywords

CHOLINE; CREATINE; INOSITOL; N ACETYLASPARTIC ACID; SERTRALINE; ASPARTIC ACID; N-ACETYLASPARTATE; PROTON; SEROTONIN UPTAKE INHIBITOR;

EID: 84925535045     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-014-0545-1     Document Type: Article
Times cited : (12)

References (42)
  • 1
    • 0023095954 scopus 로고
    • Local cerebral glucose metabolic rates in obsessive–compulsive disorder. A comparison with rates in unipolar depression and in normal controls
    • PID: 3493749
    • Baxter LR Jr, Phelps ME, Mazziotta JC, Guze BH, Schwartz JM, Selin CE (1987) Local cerebral glucose metabolic rates in obsessive–compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Arch Gen Psychiatry 44:211–218
    • (1987) Arch Gen Psychiatry , vol.44 , pp. 211-218
    • Baxter, L.R.1    Phelps, M.E.2    Mazziotta, J.C.3    Guze, B.H.4    Schwartz, J.M.5    Selin, C.E.6
  • 3
    • 0024475356 scopus 로고
    • Cerebral glucose metabolism in childhood-onset obsessive–compulsive disorder
    • COI: 1:CAS:528:DyaK3MXksVOitLk%3D, PID: 2786402
    • Swedo SE, Schapiro MB, Grady CL, Cheslow DL, Leonard HL, Kumar A et al (1989) Cerebral glucose metabolism in childhood-onset obsessive–compulsive disorder. Arch Gen Psychiatry 46:518–523
    • (1989) Arch Gen Psychiatry , vol.46 , pp. 518-523
    • Swedo, S.E.1    Schapiro, M.B.2    Grady, C.L.3    Cheslow, D.L.4    Leonard, H.L.5    Kumar, A.6
  • 4
    • 0028036323 scopus 로고
    • Regional cerebral blood flow measured during symptom provocation in obsessive–compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography
    • COI: 1:STN:280:DyaK2c7gslSrsA%3D%3D, PID: 8279930
    • Rauch SL, Jenike MA, Alpert NM, Baer L, Breiter HC, Savage CR, Fischman AJ (1994) Regional cerebral blood flow measured during symptom provocation in obsessive–compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry 51:62–70
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 62-70
    • Rauch, S.L.1    Jenike, M.A.2    Alpert, N.M.3    Baer, L.4    Breiter, H.C.5    Savage, C.R.6    Fischman, A.J.7
  • 5
    • 8944255629 scopus 로고    scopus 로고
    • Functional magnetic resonance imaging of symptom provocation in obsessive–compulsive disorder
    • COI: 1:STN:280:DyaK283otVSmtQ%3D%3D, PID: 8660126
    • Breiter HC, Rauch SL, Kwong KK, Baker JR, Weisskoff RM, Kennedy DN et al (1996) Functional magnetic resonance imaging of symptom provocation in obsessive–compulsive disorder. Arch Gen Psychiatry 53:595–606
    • (1996) Arch Gen Psychiatry , vol.53 , pp. 595-606
    • Breiter, H.C.1    Rauch, S.L.2    Kwong, K.K.3    Baker, J.R.4    Weisskoff, R.M.5    Kennedy, D.N.6
  • 6
    • 0033730742 scopus 로고    scopus 로고
    • fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder
    • COI: 1:STN:280:DC%2BD3M%2FnsVKqsg%3D%3D, PID: 11104844
    • Adler CM, McDonough-Ryan P, Sax KW, Holland SK, Arndt S, Strakowski SM (2000) fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder. J Psychiatr Res 34:317–324
    • (2000) J Psychiatr Res , vol.34 , pp. 317-324
    • Adler, C.M.1    McDonough-Ryan, P.2    Sax, K.W.3    Holland, S.K.4    Arndt, S.5    Strakowski, S.M.6
  • 8
    • 84870716973 scopus 로고    scopus 로고
    • A critical review of magnetic resonance spectroscopy studies of obsessive–compulsive disorder
    • PID: 22831979
    • Brennan BP, Rauch SL, Jensen JE, Pope HG Jr (2013) A critical review of magnetic resonance spectroscopy studies of obsessive–compulsive disorder. Biol Psychiatry 73:24–31
    • (2013) Biol Psychiatry , vol.73 , pp. 24-31
    • Brennan, B.P.1    Rauch, S.L.2    Jensen, J.E.3    Pope, H.G.4
  • 9
    • 0028978925 scopus 로고
    • N-acetylaspartate in neuropsychiatric disorders
    • COI: 1:CAS:528:DyaK2MXoslKjsr4%3D, PID: 8532851
    • Tsai G, Coyle JT (1995) N-acetylaspartate in neuropsychiatric disorders. Prog Neurobiol 46:531–540
    • (1995) Prog Neurobiol , vol.46 , pp. 531-540
    • Tsai, G.1    Coyle, J.T.2
  • 10
    • 0031552516 scopus 로고    scopus 로고
    • 1H-magnetic resonance spectroscopy in obsessive–compulsive disorder: evidence for neuronal loss in the cingulate gyrus and the right striatum
    • COI: 1:STN:280:DyaK2szpvFOlsQ%3D%3D, PID: 9255862
    • Ebert D, Speck O, König A, Berger M, Hennig J, Hohagen F (1997) 1H-magnetic resonance spectroscopy in obsessive–compulsive disorder: evidence for neuronal loss in the cingulate gyrus and the right striatum. Psychiatry Res 74:173–176
    • (1997) Psychiatry Res , vol.74 , pp. 173-176
    • Ebert, D.1    Speck, O.2    König, A.3    Berger, M.4    Hennig, J.5    Hohagen, F.6
  • 11
    • 78449291633 scopus 로고    scopus 로고
    • Evidence that the tri-cellular metabolism of N-acetylaspartate functions as the brain’s “operating system”: how NAA metabolism supports meaningful intercellular frequency-encoded communications
    • COI: 1:CAS:528:DC%2BC3cXhtlaqtb%2FM, PID: 20563610
    • Baslow MH (2010) Evidence that the tri-cellular metabolism of N-acetylaspartate functions as the brain’s “operating system”: how NAA metabolism supports meaningful intercellular frequency-encoded communications. Amino Acids 39:1139–1145
    • (2010) Amino Acids , vol.39 , pp. 1139-1145
    • Baslow, M.H.1
  • 12
    • 33746902788 scopus 로고    scopus 로고
    • A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive–compulsive disorder
    • PID: 16816225
    • Jang JH, Kwon JS, Jang DP, Moon WJ, Lee JM, Ha TH et al (2006) A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive–compulsive disorder. Am J Psychiatry 163:1202–1207
    • (2006) Am J Psychiatry , vol.163 , pp. 1202-1207
    • Jang, J.H.1    Kwon, J.S.2    Jang, D.P.3    Moon, W.J.4    Lee, J.M.5    Ha, T.H.6
  • 13
    • 33846090560 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive–compulsive disorder patients
    • PID: 17208418
    • Sumitani S, Harada M, Kubo H, Ohmori T (2007) Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive–compulsive disorder patients. Psychiatry Res 154:85–92
    • (2007) Psychiatry Res , vol.154 , pp. 85-92
    • Sumitani, S.1    Harada, M.2    Kubo, H.3    Ohmori, T.4
  • 14
    • 34547799764 scopus 로고    scopus 로고
    • Functional and biochemical alterations of the medial frontal cortex in obsessive–compulsive disorder
    • PID: 17679639
    • Yücel M, Harrison BJ, Wood SJ, Fornito A, Wellard RM, Pujol J (2007) Functional and biochemical alterations of the medial frontal cortex in obsessive–compulsive disorder. Arch Gen Psychiatry 64:946–955
    • (2007) Arch Gen Psychiatry , vol.64 , pp. 946-955
    • Yücel, M.1    Harrison, B.J.2    Wood, S.J.3    Fornito, A.4    Wellard, R.M.5    Pujol, J.6
  • 15
    • 84857450290 scopus 로고    scopus 로고
    • The effect of behavior therapy on caudate N-acetyl-l-aspartic acid in adults with obsessive–compulsive disorder
    • COI: 1:CAS:528:DC%2BC38XivFOgs74%3D, PID: 22284151
    • Whiteside SP, Abramowitz JS, Port JD (2012) The effect of behavior therapy on caudate N-acetyl-l-aspartic acid in adults with obsessive–compulsive disorder. Psychiatry Res 201:10–16
    • (2012) Psychiatry Res , vol.201 , pp. 10-16
    • Whiteside, S.P.1    Abramowitz, J.S.2    Port, J.D.3
  • 16
    • 0031596210 scopus 로고    scopus 로고
    • A short echo 1H spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive–compulsive disorder and comparison subjects
    • COI: 1:STN:280:DyaK1M%2FivVKmtA%3D%3D, PID: 9812122
    • Bartha R, Stein MB, Williamson PC, Drost DJ, Neufeld RW, Carr TJ et al (1998) A short echo 1H spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive–compulsive disorder and comparison subjects. Am J Psychiatry 155:1584–1591
    • (1998) Am J Psychiatry , vol.155 , pp. 1584-1591
    • Bartha, R.1    Stein, M.B.2    Williamson, P.C.3    Drost, D.J.4    Neufeld, R.W.5    Carr, T.J.6
  • 17
    • 35348932349 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy in obsessive–compulsive disorder: a pilot investigation comparing treatment responders and non-responders
    • PID: 17904826
    • Mohamed MA, Smith MA, Schlund MW, Nestadt G, Barker PB, Hoehn-Saric R (2007) Proton magnetic resonance spectroscopy in obsessive–compulsive disorder: a pilot investigation comparing treatment responders and non-responders. Psychiatry Res 156:175–179
    • (2007) Psychiatry Res , vol.156 , pp. 175-179
    • Mohamed, M.A.1    Smith, M.A.2    Schlund, M.W.3    Nestadt, G.4    Barker, P.B.5    Hoehn-Saric, R.6
  • 18
    • 0033984804 scopus 로고    scopus 로고
    • Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive–compulsive disorder
    • COI: 1:CAS:528:DC%2BD3cXpsFantw%3D%3D, PID: 10682215
    • Fitzgerald KD, Moore GJ, Paulson LA, Stewart CM, Rosenberg DR (2000) Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive–compulsive disorder. Biol Psychiatry 47:174–182
    • (2000) Biol Psychiatry , vol.47 , pp. 174-182
    • Fitzgerald, K.D.1    Moore, G.J.2    Paulson, L.A.3    Stewart, C.M.4    Rosenberg, D.R.5
  • 19
    • 0033461184 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive–compulsive disorder
    • COI: 1:STN:280:DC%2BD3c7js1yhtQ%3D%3D, PID: 10674362
    • Ohara K, Isoda H, Suzuki Y, Takehara Y, Ochiai M, Takeda H et al (1999) Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive–compulsive disorder. Psychiatry Res 92:83–91
    • (1999) Psychiatry Res , vol.92 , pp. 83-91
    • Ohara, K.1    Isoda, H.2    Suzuki, Y.3    Takehara, Y.4    Ochiai, M.5    Takeda, H.6
  • 20
    • 77957333296 scopus 로고    scopus 로고
    • Increased N-acetylaspartate/creatine ratio in the medial prefrontal cortex among unmedicated obsessive–compulsive disorder patients
    • COI: 1:CAS:528:DC%2BC3cXhsVGhu7rN, PID: 20923427
    • Fan Q, Tan L, You C, Wang J, Ross CA, Wang X et al (2010) Increased N-acetylaspartate/creatine ratio in the medial prefrontal cortex among unmedicated obsessive–compulsive disorder patients. Psychiatry Clin Neurosci 64:483–490
    • (2010) Psychiatry Clin Neurosci , vol.64 , pp. 483-490
    • Fan, Q.1    Tan, L.2    You, C.3    Wang, J.4    Ross, C.A.5    Wang, X.6
  • 21
    • 84874292505 scopus 로고    scopus 로고
    • Reduction of N-acetylaspartate in the medial prefrontal cortex correlated with symptom severity in obsessive–compulsive disorder: meta-analyses of (1)H-MRS studies
    • PID: 22892718
    • Aoki Y, Aoki A, Suwa H (2012) Reduction of N-acetylaspartate in the medial prefrontal cortex correlated with symptom severity in obsessive–compulsive disorder: meta-analyses of (1)H-MRS studies. Transl Psychiatry 2:e153. doi:10.1038/tp.2012.78
    • (2012) Transl Psychiatry , vol.2 , pp. e153
    • Aoki, Y.1    Aoki, A.2    Suwa, H.3
  • 22
    • 33646478267 scopus 로고    scopus 로고
    • A magnetic resonance spectroscopy investigation of obsessive–compulsive disorder and anxiety
    • PID: 16507346
    • Whiteside SP, Port JD, Deacon BJ, Abramowitz JS (2006) A magnetic resonance spectroscopy investigation of obsessive–compulsive disorder and anxiety. Psychiatry Res 146:137–147
    • (2006) Psychiatry Res , vol.146 , pp. 137-147
    • Whiteside, S.P.1    Port, J.D.2    Deacon, B.J.3    Abramowitz, J.S.4
  • 23
    • 84857455639 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy in pediatric obsessive–compulsive disorder: longitudinal study before and after treatment
    • PID: 22281202
    • Lázaro L, Bargalló N, Andrés S, Falcón C, Morer A, Junqué C, Castro-Fornieles J (2012) Proton magnetic resonance spectroscopy in pediatric obsessive–compulsive disorder: longitudinal study before and after treatment. Psychiatry Res 201:17–24
    • (2012) Psychiatry Res , vol.201 , pp. 17-24
    • Lázaro, L.1    Bargalló, N.2    Andrés, S.3    Falcón, C.4    Morer, A.5    Junqué, C.6    Castro-Fornieles, J.7
  • 24
    • 45949097408 scopus 로고    scopus 로고
    • Anterior cingulate glutamate–glutamine levels predict symptom severity in women with obsessive–compulsive disorder
    • PID: 18465373
    • Yücel M, Wood SJ, Wellard RM, Harrison BJ, Fornito A, Pujol J et al (2008) Anterior cingulate glutamate–glutamine levels predict symptom severity in women with obsessive–compulsive disorder. Aust N Z J Psychiatry 42:467–477
    • (2008) Aust N Z J Psychiatry , vol.42 , pp. 467-477
    • Yücel, M.1    Wood, S.J.2    Wellard, R.M.3    Harrison, B.J.4    Fornito, A.5    Pujol, J.6
  • 27
  • 29
    • 51549099524 scopus 로고
    • The assessment of anxiety states by rating
    • COI: 1:STN:280:DyaG1M%2FmvVWisQ%3D%3D, PID: 13638508
    • Hamilton M (1959) The assessment of anxiety states by rating. Br J Med Psychol 32:50–55
    • (1959) Br J Med Psychol , vol.32 , pp. 50-55
    • Hamilton, M.1
  • 30
    • 0014186152 scopus 로고
    • Development of a rating scale for primary depressive illness
    • COI: 1:STN:280:DyaF1c7isFSnuw%3D%3D, PID: 6080235
    • Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6:278–296
    • (1967) Br J Soc Clin Psychol , vol.6 , pp. 278-296
    • Hamilton, M.1
  • 31
    • 0036162622 scopus 로고    scopus 로고
    • Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review
    • COI: 1:CAS:528:DC%2BD38XktVKqug%3D%3D, PID: 11792458
    • Baslow MH (2002) Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review. Neurochem Int 40:295–300
    • (2002) Neurochem Int , vol.40 , pp. 295-300
    • Baslow, M.H.1
  • 32
    • 0037409849 scopus 로고    scopus 로고
    • N-acetylaspartate in the vertebrate brain: metabolism and function
    • COI: 1:CAS:528:DC%2BD3sXislyjt7k%3D, PID: 12718449
    • Baslow MH (2003) N-acetylaspartate in the vertebrate brain: metabolism and function. Neurochem Res 28:941–953
    • (2003) Neurochem Res , vol.28 , pp. 941-953
    • Baslow, M.H.1
  • 33
    • 0035067040 scopus 로고    scopus 로고
    • N-acetyl aspartate—a neuronal marker?
    • COI: 1:STN:280:DC%2BD3M3hvVyltg%3D%3D, PID: 11310618
    • Barker PB (2001) N-acetyl aspartate—a neuronal marker? Ann Neurol 49:423–424
    • (2001) Ann Neurol , vol.49 , pp. 423-424
    • Barker, P.B.1
  • 34
    • 84860351184 scopus 로고    scopus 로고
    • MR spectroscopic studies of the brain in psychiatric disorders
    • Carter CS, Dalley JW, (eds), Springer, Berlin:
    • Maddock RJ, Buonocore MH (2012) MR spectroscopic studies of the brain in psychiatric disorders. In: Carter CS, Dalley JW (eds) Brain imaging in behavioral neuroscience. Springer, Berlin, pp 199–251
    • (2012) Brain imaging in behavioral neuroscience , pp. 199-251
    • Maddock, R.J.1    Buonocore, M.H.2
  • 36
    • 0028783535 scopus 로고
    • Increased cerebral blood flow during m-CPP exacerbation of obsessive–compulsive disorder
    • COI: 1:STN:280:DyaK287ivFKnsA%3D%3D, PID: 8555752
    • Hollander E, Prohovnik I, Stein DJ (1995) Increased cerebral blood flow during m-CPP exacerbation of obsessive–compulsive disorder. J Neuropsychiatry Clin Neurosci 7:485–490
    • (1995) J Neuropsychiatry Clin Neurosci , vol.7 , pp. 485-490
    • Hollander, E.1    Prohovnik, I.2    Stein, D.J.3
  • 37
    • 0026779811 scopus 로고
    • Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive–compulsive disorder
    • COI: 1:CAS:528:DyaK38XmtFSju7g%3D, PID: 1514872
    • Baxter LR Jr, Schwartz JM, Bergman KS, Szuba MP, Guze BH, Mazziotta JC et al (1992) Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive–compulsive disorder. Arch Gen Psychiatry 49:681–689
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 681-689
    • Baxter, L.R.1    Schwartz, J.M.2    Bergman, K.S.3    Szuba, M.P.4    Guze, B.H.5    Mazziotta, J.C.6
  • 38
    • 0026775576 scopus 로고
    • Cerebral glucose metabolism in childhood-onset obsessive–compulsive disorder. Revisualization during pharmacotherapy
    • COI: 1:CAS:528:DyaK38XmtVGjsb8%3D, PID: 1514873
    • Swedo SE, Pietrini P, Leonard HL, Schapiro MB, Rettew DC, Goldberger EL et al (1992) Cerebral glucose metabolism in childhood-onset obsessive–compulsive disorder. Revisualization during pharmacotherapy. Arch Gen Psychiatry 49:690–694
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 690-694
    • Swedo, S.E.1    Pietrini, P.2    Leonard, H.L.3    Schapiro, M.B.4    Rettew, D.C.5    Goldberger, E.L.6
  • 39
    • 0028982515 scopus 로고
    • [18F]FDG PET study in obsessive–compulsive disorder. A clinical/metabolic correlation study after treatment
    • COI: 1:STN:280:DyaK2M3ksFGrtw%3D%3D, PID: 7728370
    • Perani D, Colombo C, Bressi S, Bonfanti A, Grassi F, Scarone S et al (1995) [18F]FDG PET study in obsessive–compulsive disorder. A clinical/metabolic correlation study after treatment. Br J Psychiatry 166:244–250
    • (1995) Br J Psychiatry , vol.166 , pp. 244-250
    • Perani, D.1    Colombo, C.2    Bressi, S.3    Bonfanti, A.4    Grassi, F.5    Scarone, S.6
  • 40
    • 53349142645 scopus 로고    scopus 로고
    • Provocation of obsessive–compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies
    • PID: 18787662
    • Rotge JY, Guehl D, Dilharreguy B, Cuny E, Tignol J, Bioulac B et al (2008) Provocation of obsessive–compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies. J Psychiatry Neurosci 33:405–412
    • (2008) J Psychiatry Neurosci , vol.33 , pp. 405-412
    • Rotge, J.Y.1    Guehl, D.2    Dilharreguy, B.3    Cuny, E.4    Tignol, J.5    Bioulac, B.6
  • 42
    • 0642365668 scopus 로고    scopus 로고
    • Neurochemical analyses in pediatric obsessive–compulsive disorder in patients treated with cognitive-behavioral therapy
    • PID: 14566164
    • Benazon NR, Moore GJ, Rosenberg DR (2003) Neurochemical analyses in pediatric obsessive–compulsive disorder in patients treated with cognitive-behavioral therapy. J Am Acad Child Adolesc Psychiatry 42:1279–1285
    • (2003) J Am Acad Child Adolesc Psychiatry , vol.42 , pp. 1279-1285
    • Benazon, N.R.1    Moore, G.J.2    Rosenberg, D.R.3


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