Expression of autophagy-related proteins ATG5 and FIP200 predicts favorable disease-free survival in patients with breast cancer

Biochemical and Biophysical Research Communications

Volumn 458, Issue 4, 2015, Pages 816-822

  Wang, Lei ^a,b   Yao, Ling ^a,b   Zheng, Yi Zi ^a,b   Xu, Qing ^b   Liu, Xiu Ping ^b   Hu, Xin ^a,b   Wang, Peng ^c,d   Shao, Zhi Ming ^a,b  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c SHANGHAI ADVANCED RESEARCH INSTITUTE   (China)

^d SHANGHAITECH UNIVERSITY   (China)

Author keywords

ATG5; Autophagy; Breast cancer; Disease free survival; FIP200

Indexed keywords

AUTOPHAGY PROTEIN 5; FAK FAMILY KINASE INTERACTING PROTEIN OF 200 KDA; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; ATG5 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; RB1CC1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER PROGNOSIS; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; AUTOPHAGY; BREAST; BREAST NEOPLASMS; COHORT ANALYSIS; MIDDLE AGED; PATHOLOGY; PROGNOSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AUTOPHAGY; BREAST; BREAST NEOPLASMS; COHORT STUDIES; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; PROGNOSIS; PROTEIN-TYROSINE KINASES; RETROSPECTIVE STUDIES;

EID: 84925522081     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.02.037     Document Type: Article

References (20)

1. J.A. Ludwig, and J.N. Weinstein Biomarkers in cancer staging, prognosis and treatment selection Nat. Rev. Cancer 5 2005 845 856
2. J.M. Bartlett, K.J. Bloom, T. Piper, T.J. Lawton, C.J. van de Velde, D.T. Ross, B.Z. Ring, R.S. Seitz, R.A. Beck, A. Hasenburg, D. Kieback, H. Putter, C. Markopoulos, L. Dirix, C. Seynaeve, and D. Rea Mammostrat as an immunohistochemical multigene assay for prediction of early relapse risk in the tamoxifen versus exemestane adjuvant multicenter trial pathology study J. Clin. Oncol. 30 2012 4477 4484
3. B. Levine, and D.J. Klionsky Development by self-digestion: molecular mechanisms and biological functions of autophagy Dev. Cell 6 2004 463 477
4. E. White Deconvoluting the context-dependent role for autophagy in cancer Nat. Rev. Cancer 12 2012 401 410
5. G. Marino, M. Niso-Santano, E.H. Baehrecke, and G. Kroemer Self-consumption: the interplay of autophagy and apoptosis Nat. Rev. Mol. Cell Biol. 15 2014 81 94
6. S. Chen, Y.Z. Jiang, L. Huang, R.J. Zhou, K.D. Yu, Y. Liu, and Z.M. Shao The residual tumor autophagy marker LC3B serves as a prognostic marker in local advanced breast cancer after neoadjuvant chemotherapy Clin. Cancer Res. 19 2013 6853 6862
7. R. Lazova, R.L. Camp, V. Klump, S.F. Siddiqui, R.K. Amaravadi, and J.M. Pawelek Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome Clin. Cancer Res. 18 2012 370 379
8. N. Mizushima, A. Yamamoto, M. Hatano, Y. Kobayashi, Y. Kabeya, K. Suzuki, T. Tokuhisa, Y. Ohsumi, and T. Yoshimori Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells J. Cell Biol. 152 2001 657 668
9. T. Hara, A. Takamura, C. Kishi, S. Iemura, T. Natsume, J.L. Guan, and N. Mizushima FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells J. Cell Biol. 181 2008 497 510
10. S. Yousefi, R. Perozzo, I. Schmid, A. Ziemiecki, T. Schaffner, L. Scapozza, T. Brunner, and H.U. Simon Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis Nat. Cell Biol. 8 2006 1124 1132
11. Z.K. Melkoumian, X. Peng, B. Gan, X. Wu, and J.L. Guan Mechanism of cell cycle regulation by FIP200 in human breast cancer cells Cancer Res. 65 2005 6676 6684
12. T. Chano, K. Ikebuchi, Y. Tomita, Y. Jin, H. Inaji, M. Ishitobi, K. Teramoto, Y. Ochi, H. Tameno, I. Nishimura, K. Minami, H. Inoue, T. Isono, M. Saitoh, T. Shimada, Y. Hisa, and H. Okabe RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients PLoS One 5 2010 e15737
13. X. Li, X. Wan, H. Chen, S. Yang, Y. Liu, W. Mo, D. Meng, W. Du, Y. Huang, H. Wu, J. Wang, T. Li, and Y. Li Identification of miR-133b and RB1CC1 as independent predictors for biochemical recurrence and potential therapeutic targets for prostate cancer Clin. Cancer Res. 20 2014 2312 2325
14. H. Tameno, T. Chano, K. Ikebuchi, Y. Ochi, A. Arai, M. Kishimoto, T. Shimada, Y. Hisa, and H. Okabe Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers Head Neck 34 2012 674 680
15. Y.Z. Zheng, Z.G. Cao, X. Hu, and Z.M. Shao The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer Breast Cancer Res. Treat. 145 2014 349 358
16. W.T. Peng, X. Hu, L. Yao, Y.Z. Jiang, and Z.M. Shao Elevated expression of girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer Ann. Surg. Oncol. 2014
17. K. Ikebuchi, T. Chano, Y. Ochi, H. Tameno, T. Shimada, Y. Hisa, and H. Okabe RB1CC1 activates the promoter and expression of RB1 in human cancer Int. J. Cancer 125 2009 861 867
18. B. French, P. Saha-Chaudhuri, B. Ky, T.P. Cappola, and P.J. Heagerty Development and evaluation of multi-marker risk scores for clinical prognosis Stat. Methods Med. Res. 2012
19. A. Thorburn, D.H. Thamm, and D.L. Gustafson Autophagy and cancer therapy Mol. Pharmacol. 85 2014 830 838
20. D.A. Gewirtz The four faces of autophagy: implications for cancer therapy Cancer Res. 74 2014 647 651