HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44+/CD24-/low tumor-initiating subpopulation in basal-like breast cancer

Journal of Steroid Biochemistry and Molecular Biology

Volumn 148, Issue , 2015, Pages 111-121

  So, Jae Young ^a   Wahler, Joseph ^a   Das Gupta, Soumyasri ^a   Salerno, David M ^a   Maehr, Hubert ^a   Uskokovic, Milan ^a   Suh, Nanjoo ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Breast cancer; CD44+ CD24 low cells; Gemini vitamin D analog; HES1; Notch signaling; Tumor initiating cells

Indexed keywords

1,25 DIHYDROXY 21 ( 3 HYDROXY 3 DEUTEROMETHYL 4,4,4 TRIDEUTEROBUTYL) 23 YNE 26,27 HEXAFLUOROCHOLECALCIFEROL; CD24 ANTIGEN; DLL1 PROTEIN; HERMES ANTIGEN; JAGGED1; JAGGED2; MEMBRANE PROTEIN; MESSENGER RNA; MYC PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; 1,25-DIHYDROXY-21-(3-HYDROXY-3-METHYL-4,4,4-TRIBUTYL)-23-YNE-26,27-HEXAFLUOROCHOLECALCIFEROL; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CALCITRIOL; CALCITRIOL RECEPTOR; CD24 PROTEIN, HUMAN; CD44 PROTEIN, HUMAN; HES1 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; NOTCH1 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ARTICLE; BASAL LIKE BREAST CANCER; CANCER STEM CELL; CELL FUNCTION; CELL PROLIFERATION; CELL SUBPOPULATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; GENE REPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MEDIATOR; ONCOGENE C MYC; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BREAST NEOPLASMS; CARCINOMA, BASAL CELL; DRUG EFFECTS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANTIGENS, CD24; ANTIGENS, CD44; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; BREAST NEOPLASMS; CALCITRIOL; CARCINOMA, BASAL CELL; CELL PROLIFERATION; FEMALE; FLOW CYTOMETRY; HOMEODOMAIN PROTEINS; HUMANS; MICROSCOPY, FLUORESCENCE; NEOPLASTIC STEM CELLS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, NOTCH1; RECEPTORS, CALCITRIOL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

EID: 84925515492     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.12.013     Document Type: Article

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