Protective effect of oligomeric proanthocyanidins against alcohol-induced liver steatosis and injury in mice

Biochemical and Biophysical Research Communications

Volumn 458, Issue 4, 2015, Pages 757-762

  Wang, Zhiguo ^a   Su, Bo ^b   Fan, Sumei ^c   Fei, Haixia ^d   Zhao, Wei ^e  

^a Hospital of Integrated Chinese Western Medicine in Jiangsu Province   (China)

^b Huai'an Maternal and Child Health Care Center   (China)

^c Huai'an Second People's Hospital   (China)

^d Jiangsu Province Official Hospital   (China)

^e WOMEN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Alcoholic liver disease; AMP activated protein kinase; Inflammatory cytokines; Lipid accumulation; Oligomeric proanthocyanidins; Oxidative stress

Indexed keywords

ASPARTATE AMINOTRANSFERASE; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; PROANTHOCYANIDIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; ALCOHOL; CYTOKINE; PROTECTIVE AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FATTY LIVER; FEMALE; GENE EXPRESSION; LIPID STORAGE; LIPOGENESIS; LIPOPROTEIN BLOOD LEVEL; LIVER INJURY; LIVER PROTECTION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; DRUG EFFECTS; ENZYME ACTIVATION; FATTY LIVER, ALCOHOLIC; GENE EXPRESSION REGULATION; GENETICS; LIPID METABOLISM; LIVER; METABOLISM; PATHOLOGY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CYTOKINES; ENZYME ACTIVATION; ETHANOL; FATTY LIVER, ALCOHOLIC; FEMALE; GENE EXPRESSION REGULATION; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PROANTHOCYANIDINS; PROTECTIVE AGENTS;

EID: 84925513946     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.01.153     Document Type: Article

References (27)

1. S. De Minicis, and D.A. Brenner Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex J. Gastroenterol. Hepatol. 23 2008 S98 S103
2. O. Niemela, S. Parkkila, S. Yla-Herttuala, J. Villanueva, B. Ruebner, and C.H. Halsted Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease Hepatology 22 1995 1208 1214
3. B. Nath, and G. Szabo Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity Semin. Liver Dis. 29 2009 166 177
4. B. Sid, J. Verrax, and P.B. Calderon Role of AMPK activation in oxidative cell damage: implications for alcohol-induced liver disease Biochem. Pharmacol. 86 2013 200 209
5. P. Mandrekar, and G. Szabo Signalling pathways in alcohol-induced liver inflammation J. Hepatol. 50 2009 1258 1266
6. D.G. Hardie, I.P. Salt, S.A. Hawley, and S.P. Davies AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge Biochem. J. 338 Pt 3 1999 717 722
7. M. You, M. Matsumoto, C.M. Pacold, W.K. Cho, and D.W. Crabb The role of AMP-activated protein kinase in the action of ethanol in the liver Gastroenterology 127 2004 1798 1808
8. E. Albano Oxidative mechanisms in the pathogenesis of alcoholic liver disease Mol. Aspects Med. 29 2008 9 16
9. G.E. Arteel Oxidants and antioxidants in alcohol-induced liver disease Gastroenterology 124 2003 778 790
10. X. Terra, J. Valls, X. Vitrac, J. Mérrillon, L. Arola, A. Ardèvol, C. Bladé, J. Fernández-Larrea, G. Pujadas, J. Salvadó, and M. Blay Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NF-kB signaling pathway J. Agric. Food Chem. 55 2007 4357 4365
11. R.J. Williams, J.P.E. Spencer, and C. Rice-Evans Flavonoids: antioxidants or signalling molecules? Free Radic. Biol. Med. 36 2004 838 849
12. T.K. Mao, J. Powell, J. Van de Water, C.L. Keen, H.H. Schmitz, J.F. Hammerstone, and M.E. Gershwin The effect of cocoa procyanidins on the transcription and secretion of interleukin 1 beta in peripheral blood mononuclear cells Life Sci. 66 2000 1377 1386
13. Y. Sakaguchi, H. Shirahase, K. Kunishiro, A. Ichikawa, M. Kanda, and Y. Uehara Effect of combination of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced pleurisy in rats Life Sci. 79 2006 442 447
14. W.G. Li, X.Y. Zhang, Y.J. Wu, and X. Tian Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds Acta Pharmacol. Sin. 22 2001 1117 1120
15. P.M. Kris-Etherton, M. Lefevre, G.R. Beecher, M.D. Gross, C.L. Keen, and T.D. Etherton The antioxidant and anti-inflammatory effects of flavonoids on atherosclerosis Annu. Rev. Nutr. 24 2004 511 538
16. H. Shimano, I. Shimomura, R.E. Hammer, J. Herz, J.L. Goldstein, M.S. Brown, and J.D. Horton Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene J. Clin. Investigation 100 1997 2115 2124
17. R. Bruha Alcoholic liver disease World J. Hepatology 4 2012 81
18. J. Yang, L. Craddock, S. Hong, and Z. Liu AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells J. Cell. Biochem. 106 2009 414 426
19. M. Foretz, N. Ancellin, F. Andreelli, Y. Saintillan, P. Grondin, A. Kahn, B. Thorens, S. Vaulont, and B. Viollet Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver Diabetes 54 2005 1331 1339
20. G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M.F. Hirshman, L.J. Goodyear, and D.E. Moller Role of AMP-activated protein kinase in mechanism of metformin action J. Clin. Investigation 108 2001 1167 1174
21. X. Yang, C. Dong, and G. Ren Effect of Soyasaponins-rich extract from soybean on acute alcohol-induced hepatotoxicity in mice J. Agric. Food Chem. 59 2011 1138 1144
22. I.N. Hines, and M.D. Wheeler Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis Am. J. Physiol. Gastrointest. Liver Physiol. 287 2004 G310 G314
23. C.P. Day, and O.F. James Steatohepatitis: a tale of two "hits"? Gastroenterology 114 1998 842 845
24. K. Wang Molecular mechanisms of hepatic apoptosis Cell Death Dis. 5 2014 e996
25. R. Ding, K. Tian, L. Huang, C. He, Y. Jiang, Y. Wang, and J. Wan Herbal medicines for the prevention of alcoholic liver disease: a review J. Ethnopharmacol. 144 2012 457 465
26. Y.C. Long AMP-activated protein kinase signaling in metabolic regulation J. Clin. Investigation 116 2006 1776 1783
27. V. Purohit, B. Gao, and B. Song Molecular mechanisms of alcoholic fatty liver Alcohol. Clin. Exp. Res. 33 2009 191 205