Engineering Clostridium acetobutylicum with a histidine kinase knockout for enhanced n-butanol tolerance and production

Applied Microbiology and Biotechnology

Volumn 99, Issue 2, 2015, Pages 1011-1022

  Xu, Mengmeng ^a   Zhao, Jingbo ^a   Yu, Le ^a   Tang, I Ching ^b   Xue, Chuang ^c   Yang, Shang Tian ^a  

^a The Ohio State University   (United States)

^b Bioprocessing Innovative Company   (United States)

^c DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

ABE fermentation; Butanol tolerance; C. acetobutylicum; Gene knockout; Histidine kinase; Metabolic engineering

Indexed keywords

AMINO ACIDS; CELL PROLIFERATION; CLOSTRIDIUM; ENZYMES; FERMENTATION; GENES; METABOLISM;

ABE FERMENTATIONS; C-TERMINAL TRUNCATION; C. ACETOBUTYLICUM; CLOSTRIDIUM ACETOBUTYLICUM; COMPARATIVE GENOMIC; FIBROUS BED BIOREACTOR; GENE KNOCKOUT; HISTIDINE KINASE;

METABOLIC ENGINEERING;

BUTANOL; GENOMIC DNA; PROTEIN HISTIDINE KINASE; BACTERIAL DNA; CULTURE MEDIUM; GLUCOSE; PROTEIN KINASE; PROTEIN-HISTIDINE KINASE; SOLVENT;

ANALYTIC METHOD; ARTICLE; BACTERIAL MUTATION; BACTERIAL STRAIN; BACTERIUM CULTURE; BATCH FERMENTATION; BIOSYNTHESIS; CLOSTRIDIUM ACETOBUTYLICUM; GENE DELETION; GENE INACTIVATION; METABOLIC ENGINEERING; NONHUMAN; PLASMID; SOUTHERN BLOTTING; CHEMISTRY; CULTURE MEDIUM; DNA SEQUENCE; FERMENTATION; GENETICS; METABOLISM; MICROBIOLOGY; MOLECULAR CLONING; MUTATION; PROCEDURES;

1-BUTANOL; CLONING, MOLECULAR; CLOSTRIDIUM ACETOBUTYLICUM; CULTURE MEDIA; DNA, BACTERIAL; FERMENTATION; GLUCOSE; INDUSTRIAL MICROBIOLOGY; METABOLIC ENGINEERING; MUTATION; PLASMIDS; PROTEIN KINASES; SEQUENCE ANALYSIS, DNA; SOLVENTS;

EID: 84925497895     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-014-6249-7     Document Type: Article

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