메뉴 건너뛰기




Volumn 14, Issue 6, 2012, Pages 630-641

Targeted mutagenesis of the Clostridium acetobutylicum acetone-butanol-ethanol fermentation pathway

Author keywords

Acetate kinase; Acetoacetate decarboxylase; Alcohol aldehyde dehydrogenases; Butanol dehydrogenases; CAP0059; Clostridium; ClosTron; CoA transferase; Phosphotransbutyrylase; Thiolase

Indexed keywords

ACETATE KINASE; CAP0059; CLOSTRON; COA TRANSFERASE; DECARBOXYLASES; PHOSPHOTRANSBUTYRYLASE; THIOLASE;

EID: 84869014233     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2012.09.001     Document Type: Article
Times cited : (134)

References (51)
  • 1
    • 26444483354 scopus 로고    scopus 로고
    • Transcriptional program of early sporulation and stationary-phase events in Clostridium acetobutylicum
    • Alsaker K.V., Papoutsakis E.T. Transcriptional program of early sporulation and stationary-phase events in Clostridium acetobutylicum. J. Bacteriol. 2005, 187:7103-7118.
    • (2005) J. Bacteriol. , vol.187 , pp. 7103-7118
    • Alsaker, K.V.1    Papoutsakis, E.T.2
  • 2
    • 77950629484 scopus 로고    scopus 로고
    • Metabolite stress and tolerance in the production of biofuels and chemicals: gene-expression-based systems analysis of butanol, butyrate, and acetate stresses in the anaerobe Clostridium acetobutylicum
    • Alsaker K.V., Paredes C., Papoutsakis E.T. Metabolite stress and tolerance in the production of biofuels and chemicals: gene-expression-based systems analysis of butanol, butyrate, and acetate stresses in the anaerobe Clostridium acetobutylicum. Biotechnol. Bioeng. 2010, 105:1131-1147.
    • (2010) Biotechnol. Bioeng. , vol.105 , pp. 1131-1147
    • Alsaker, K.V.1    Paredes, C.2    Papoutsakis, E.T.3
  • 3
    • 80052364547 scopus 로고    scopus 로고
    • Genetic manipulation of butyrate formation pathways in Clostridium butyricum
    • Cai G.Q., Jin B., Saint C., Monis P. Genetic manipulation of butyrate formation pathways in Clostridium butyricum. J. Biotechnol. 2011, 155:269-274.
    • (2011) J. Biotechnol. , vol.155 , pp. 269-274
    • Cai, G.Q.1    Jin, B.2    Saint, C.3    Monis, P.4
  • 4
    • 84863792386 scopus 로고    scopus 로고
    • Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between tcdC genotype and toxin production
    • Cartman S.T., Kelly M.L., Heeg D., Heap J.T., Minton N.P. Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between tcdC genotype and toxin production. Appl. Environ. Microbiol. 2012, 78:4683-4690.
    • (2012) Appl. Environ. Microbiol. , vol.78 , pp. 4683-4690
    • Cartman, S.T.1    Kelly, M.L.2    Heeg, D.3    Heap, J.T.4    Minton, N.P.5
  • 5
    • 77954254518 scopus 로고    scopus 로고
    • Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum
    • Cooksley C.M., Davis I.J., Winzer K., Chan W.C., Peck M.W., Minton N.P. Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum. Appl. Environ. Microbiol. 2010, 76:4448-4460.
    • (2010) Appl. Environ. Microbiol. , vol.76 , pp. 4448-4460
    • Cooksley, C.M.1    Davis, I.J.2    Winzer, K.3    Chan, W.C.4    Peck, M.W.5    Minton, N.P.6
  • 6
    • 77952800968 scopus 로고    scopus 로고
    • Effects of blending gasoline with ethanol and butanol on engine efficiency and emissions using a direct-injection, spark-ignition engine
    • In: Proceedings of the 2009 Spring Technical Conference of the Asme Internal Combustion Engine Division
    • Cooney, C., Wallner, T., McConnell, S., Gillen, J.C., Abell, C., Miers, S.A., Naber, J.D., 2009. Effects of blending gasoline with ethanol and butanol on engine efficiency and emissions using a direct-injection, spark-ignition engine. In: Proceedings of the 2009 Spring Technical Conference of the Asme Internal Combustion Engine Division. 157-165.
    • (2009) , pp. 157-165
    • Cooney, C.1    Wallner, T.2    McConnell, S.3    Gillen, J.C.4    Abell, C.5    Miers, S.A.6    Naber, J.D.7
  • 7
    • 0032986060 scopus 로고    scopus 로고
    • Antisense RNA strategies for metabolic engineering of Clostridium acetobutylicum
    • Desai R.P., Papoutsakis E.T. Antisense RNA strategies for metabolic engineering of Clostridium acetobutylicum. Appl. Environ. Microbiol. 1999, 65:936-945.
    • (1999) Appl. Environ. Microbiol. , vol.65 , pp. 936-945
    • Desai, R.P.1    Papoutsakis, E.T.2
  • 8
    • 84855469161 scopus 로고    scopus 로고
    • Development of an anhydrotetracycline-inducible gene expression system for solvent-producing Clostridium acetobutylicum: a useful tool for strain engineering
    • Dong H., Tao W., Zhang Y., Li.Y. Development of an anhydrotetracycline-inducible gene expression system for solvent-producing Clostridium acetobutylicum: a useful tool for strain engineering. Metab. Eng. 2012, 14:59-67.
    • (2012) Metab. Eng. , vol.14 , pp. 59-67
    • Dong, H.1    Tao, W.2    Zhang, Y.3    Li, Y.4
  • 9
    • 38349038031 scopus 로고    scopus 로고
    • Formation of solvents in clostridia
    • CRC Press, New York, P. Durre (Ed.)
    • Durre P. Formation of solvents in clostridia. Handbook on Clostridia 2005, 671-693. CRC Press, New York. P. Durre (Ed.).
    • (2005) Handbook on Clostridia , pp. 671-693
    • Durre, P.1
  • 10
    • 41349120749 scopus 로고    scopus 로고
    • Fermentative butanol production: bulk chemical and biofuel
    • Durre P. Fermentative butanol production: bulk chemical and biofuel. Ann. N.Y. Acad. Sci. 2008, 1125:353-362.
    • (2008) Ann. N.Y. Acad. Sci. , vol.1125 , pp. 353-362
    • Durre, P.1
  • 11
    • 79957975067 scopus 로고    scopus 로고
    • Fermentative production of butanol-the academic perspective
    • Durre P. Fermentative production of butanol-the academic perspective. Curr. Opin. Biotechnol. 2011, 22:331-336.
    • (2011) Curr. Opin. Biotechnol. , vol.22 , pp. 331-336
    • Durre, P.1
  • 13
    • 0027383357 scopus 로고
    • Cloning, sequencing and molecular analysis of the sol operon of Clostridium acetobutylicum, a chromosomal locus involved in solventogenesis
    • Fischer R.J., J.H., Durre P. Cloning, sequencing and molecular analysis of the sol operon of Clostridium acetobutylicum, a chromosomal locus involved in solventogenesis. J. Bacteriol. 1993, 175:6959-6969.
    • (1993) J. Bacteriol. , vol.175 , pp. 6959-6969
    • Fischer, R.J.J.H.1    Durre, P.2
  • 14
    • 0036180998 scopus 로고    scopus 로고
    • Molecular characterization and transcriptional analysis of adhE2, the gene encoding the NADH-dependent aldehyde/alcohol dehydrogenase responsible for butanol production in alcohologenic cultures of Clostridium acetobutylicum ATCC 824
    • Fontaine L., Meynial-Salles I., Girbal L., Yang X., Croux C., Soucaille P. Molecular characterization and transcriptional analysis of adhE2, the gene encoding the NADH-dependent aldehyde/alcohol dehydrogenase responsible for butanol production in alcohologenic cultures of Clostridium acetobutylicum ATCC 824. J. Bacteriol. 2002, 184:821-830.
    • (2002) J. Bacteriol. , vol.184 , pp. 821-830
    • Fontaine, L.1    Meynial-Salles, I.2    Girbal, L.3    Yang, X.4    Croux, C.5    Soucaille, P.6
  • 15
    • 0029846031 scopus 로고    scopus 로고
    • Genetic manipulation of acid formation pathways by gene inactivation in Clostridium acetobutylicum ATCC 824
    • Pt 8
    • Green E.M., Boynton Z.L., Harris L.M., Rudolph F.B., Papoutsakis E.T., Bennett G.N. Genetic manipulation of acid formation pathways by gene inactivation in Clostridium acetobutylicum ATCC 824. Microbiology 1996, 142:2079-2086. Pt 8.
    • (1996) Microbiology , vol.142 , pp. 2079-2086
    • Green, E.M.1    Boynton, Z.L.2    Harris, L.M.3    Rudolph, F.B.4    Papoutsakis, E.T.5    Bennett, G.N.6
  • 16
    • 78650924319 scopus 로고    scopus 로고
    • Genome-wide gene expression analysis of the switch between acidogenesis and solventogenesis in continuous cultures of Clostridium acetobutylicum
    • Grimmler C., Janssen H., Krausse D., Fischer R.J., Bahl H., Dürre P., Liebl W., Ehrenreich A. Genome-wide gene expression analysis of the switch between acidogenesis and solventogenesis in continuous cultures of Clostridium acetobutylicum. J. Mol. Microbiol. Biotechnol. 2011, 20:1-15.
    • (2011) J. Mol. Microbiol. Biotechnol. , vol.20 , pp. 1-15
    • Grimmler, C.1    Janssen, H.2    Krausse, D.3    Fischer, R.J.4    Bahl, H.5    Dürre, P.6    Liebl, W.7    Ehrenreich, A.8
  • 17
    • 79960743374 scopus 로고    scopus 로고
    • Acetone production in solventogenic Clostridium species: new insights from non-enzymatic decarboxylation of acetoacetate
    • Han B., Gopalan V., Ezeji T.C. Acetone production in solventogenic Clostridium species: new insights from non-enzymatic decarboxylation of acetoacetate. Appl. Microbiol. Biot. 2011, 91:565-576.
    • (2011) Appl. Microbiol. Biot. , vol.91 , pp. 565-576
    • Han, B.1    Gopalan, V.2    Ezeji, T.C.3
  • 18
    • 0021261020 scopus 로고
    • Intermediary metabolism in Clostridium acetobutylicum: levels of enzymes involved in the formation of acetate and butyrate
    • Hartmanis M.G., Gatenbeck S. Intermediary metabolism in Clostridium acetobutylicum: levels of enzymes involved in the formation of acetate and butyrate. Appl. Environ. Microbiol. 1984, 47:1277-1283.
    • (1984) Appl. Environ. Microbiol. , vol.47 , pp. 1277-1283
    • Hartmanis, M.G.1    Gatenbeck, S.2
  • 23
    • 84860367333 scopus 로고    scopus 로고
    • Global transcriptional changes of Clostridium acetobutylicum cultures with increased butanol:acetone ratios
    • Honicke D., Janssen H., Grimmler C., Ehrenreich A., Lutke-Eversloh T. Global transcriptional changes of Clostridium acetobutylicum cultures with increased butanol:acetone ratios. New Biotechnol. 2012, 29:485-493.
    • (2012) New Biotechnol. , vol.29 , pp. 485-493
    • Honicke, D.1    Janssen, H.2    Grimmler, C.3    Ehrenreich, A.4    Lutke-Eversloh, T.5
  • 24
    • 77955559194 scopus 로고    scopus 로고
    • A proteomic and transcriptional view of acidogenic and solventogenic steady-state cells of Clostridium acetobutylicum in a chemostat culture
    • Janssen H., Doring C., Ehrenreich A., Voigt B., Hecker M., Bahl H., Fischer R.J. A proteomic and transcriptional view of acidogenic and solventogenic steady-state cells of Clostridium acetobutylicum in a chemostat culture. Appl. Microbiol. Biot. 2010, 87:2209-2226.
    • (2010) Appl. Microbiol. Biot. , vol.87 , pp. 2209-2226
    • Janssen, H.1    Doring, C.2    Ehrenreich, A.3    Voigt, B.4    Hecker, M.5    Bahl, H.6    Fischer, R.J.7
  • 25
    • 68049142960 scopus 로고    scopus 로고
    • Disruption of the acetoacetate decarboxylase gene in solvent-producing Clostridium acetobutylicum increases the butanol ratio
    • Jiang Y., Xu C., Dong F., Yang Y., Jiang W., Yang S. Disruption of the acetoacetate decarboxylase gene in solvent-producing Clostridium acetobutylicum increases the butanol ratio. Metab. Eng. 2009, 11:284-291.
    • (2009) Metab. Eng. , vol.11 , pp. 284-291
    • Jiang, Y.1    Xu, C.2    Dong, F.3    Yang, Y.4    Jiang, W.5    Yang, S.6
  • 27
    • 0022970603 scopus 로고
    • Acetone-butanol fermentation revisited
    • Jones D.T., Woods D.R. Acetone-butanol fermentation revisited. Microbiol. Rev. 1986, 50:484-524.
    • (1986) Microbiol. Rev. , vol.50 , pp. 484-524
    • Jones, D.T.1    Woods, D.R.2
  • 29
    • 84862670774 scopus 로고    scopus 로고
    • Disruption of the acetate kinase (ack) gene of Clostridium acetobutylicum results in delayed acetate production
    • Kuit W., Minton N.P., Lopez-Contreras A.M., Eggink G. Disruption of the acetate kinase (ack) gene of Clostridium acetobutylicum results in delayed acetate production. Appl. Microbiol. Biot. 2012, 94:729-741.
    • (2012) Appl. Microbiol. Biot. , vol.94 , pp. 729-741
    • Kuit, W.1    Minton, N.P.2    Lopez-Contreras, A.M.3    Eggink, G.4
  • 33
    • 80052029042 scopus 로고    scopus 로고
    • Switching Clostridium acetobutylicum to an ethanol producer by disruption of the butyrate/butanol fermentative pathway
    • Lehmann D., Lutke-Eversloh T. Switching Clostridium acetobutylicum to an ethanol producer by disruption of the butyrate/butanol fermentative pathway. Metab. Eng. 2011, 13:464-473.
    • (2011) Metab. Eng. , vol.13 , pp. 464-473
    • Lehmann, D.1    Lutke-Eversloh, T.2
  • 34
    • 80052625837 scopus 로고    scopus 로고
    • Metabolic engineering of Clostridium acetobutylicum: recent advances to improve butanol production
    • Lutke-Eversloh T., Bahl H. Metabolic engineering of Clostridium acetobutylicum: recent advances to improve butanol production. Curr. Opin. Biotech. 2011, 22:634-647.
    • (2011) Curr. Opin. Biotech. , vol.22 , pp. 634-647
    • Lutke-Eversloh, T.1    Bahl, H.2
  • 35
    • 14744283496 scopus 로고
    • Expression of cloned homologous fermentative genes in Clostridium acetobutylicum ATCC 824
    • Mermelstein L.D., Welker N.E., Bennett G.N., Papoutsakis E.T. Expression of cloned homologous fermentative genes in Clostridium acetobutylicum ATCC 824. Biotechnology (NY) 1992, 10:190-195.
    • (1992) Biotechnology (NY) , vol.10 , pp. 190-195
    • Mermelstein, L.D.1    Welker, N.E.2    Bennett, G.N.3    Papoutsakis, E.T.4
  • 36
    • 0027957210 scopus 로고
    • Molecular characterization of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824
    • Nair R.V., Bennett G.N., Papoutsakis E.T. Molecular characterization of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824. J. Bacteriol. 1994, 176:871-885.
    • (1994) J. Bacteriol. , vol.176 , pp. 871-885
    • Nair, R.V.1    Bennett, G.N.2    Papoutsakis, E.T.3
  • 38
    • 0015155688 scopus 로고
    • Oxygen and the growth and metabolism of Clostridium acetobutylicum
    • O'Brien R.W., Morris J.G. Oxygen and the growth and metabolism of Clostridium acetobutylicum. J. Gen. Microbiol. 1971, 68:307-318.
    • (1971) J. Gen. Microbiol. , vol.68 , pp. 307-318
    • O'Brien, R.W.1    Morris, J.G.2
  • 41
    • 0028830955 scopus 로고
    • Differential induction of genes related to solvent formation during the shift from acidogenesis to solventogenesis in continuous culture of Clostridium acetobutylicum
    • Sauer U., Durre P. Differential induction of genes related to solvent formation during the shift from acidogenesis to solventogenesis in continuous culture of Clostridium acetobutylicum. Fems. Microbiol. Lett. 1995, 125:115-120.
    • (1995) Fems. Microbiol. Lett. , vol.125 , pp. 115-120
    • Sauer, U.1    Durre, P.2
  • 42
    • 58149268329 scopus 로고    scopus 로고
    • Aldehyde-alcohol dehydrogenase and/or thiolase overexpression coupled with CoA transferase downregulation lead to higher alcohol titers and selectivity in Clostridium acetobutylicum fermentations
    • Sillers R., Al-Hinai M.A., Papoutsakis E.T. Aldehyde-alcohol dehydrogenase and/or thiolase overexpression coupled with CoA transferase downregulation lead to higher alcohol titers and selectivity in Clostridium acetobutylicum fermentations. Biotechnol. Bioeng. 2009, 102:38-49.
    • (2009) Biotechnol. Bioeng. , vol.102 , pp. 38-49
    • Sillers, R.1    Al-Hinai, M.A.2    Papoutsakis, E.T.3
  • 43
    • 57049169148 scopus 로고    scopus 로고
    • Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance
    • Sillers R., Chow A., Tracy B., Papoutsakis E.T. Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance. Metab. Eng. 2008, 10:321-332.
    • (2008) Metab. Eng. , vol.10 , pp. 321-332
    • Sillers, R.1    Chow, A.2    Tracy, B.3    Papoutsakis, E.T.4
  • 45
    • 79955011057 scopus 로고    scopus 로고
    • Multiple orphan histidine kinases interact directly with Spo0A to control the initiation of endospore formation in Clostridium acetobutylicum
    • Steiner E., Dago A.E., Young D.I., Heap J.T., Minton N.P., Hoch J.A., Young M. Multiple orphan histidine kinases interact directly with Spo0A to control the initiation of endospore formation in Clostridium acetobutylicum. Mol. Microbiol. 2011, 80:641-654.
    • (2011) Mol. Microbiol. , vol.80 , pp. 641-654
    • Steiner, E.1    Dago, A.E.2    Young, D.I.3    Heap, J.T.4    Minton, N.P.5    Hoch, J.A.6    Young, M.7
  • 46
    • 84857087282 scopus 로고    scopus 로고
    • An agr Quorum sensing system that regulates granulose formation and sporulation in Clostridium acetobutylicum
    • Steiner E., Scott J., Minton N.P., Winzer K. An agr Quorum sensing system that regulates granulose formation and sporulation in Clostridium acetobutylicum. Appl. Environ. Microb. 2012, 78:1113-1122.
    • (2012) Appl. Environ. Microb. , vol.78 , pp. 1113-1122
    • Steiner, E.1    Scott, J.2    Minton, N.P.3    Winzer, K.4
  • 47
    • 0037608873 scopus 로고    scopus 로고
    • Antisense RNA downregulation of coenzyme A transferase combined with alcohol-aldehyde dehydrogenase overexpression leads to predominantly alcohologenic Clostridium acetobutylicum fermentations
    • Tummala S.B., Junne S.G., Papoutsakis E.T. Antisense RNA downregulation of coenzyme A transferase combined with alcohol-aldehyde dehydrogenase overexpression leads to predominantly alcohologenic Clostridium acetobutylicum fermentations. J. Bacteriol. 2003, 185:3644-3653.
    • (2003) J. Bacteriol. , vol.185 , pp. 3644-3653
    • Tummala, S.B.1    Junne, S.G.2    Papoutsakis, E.T.3
  • 48
    • 0026563908 scopus 로고
    • Molecular characterization of two Clostridium acetobutylicum ATCC 824 butanol dehydrogenase isozyme genes
    • Walter K.A., Bennett G.N., Papoutsakis E.T. Molecular characterization of two Clostridium acetobutylicum ATCC 824 butanol dehydrogenase isozyme genes. J. Bacteriol. 1992, 174:7149-7158.
    • (1992) J. Bacteriol. , vol.174 , pp. 7149-7158
    • Walter, K.A.1    Bennett, G.N.2    Papoutsakis, E.T.3
  • 49
    • 0033768632 scopus 로고    scopus 로고
    • Differential regulation of two thiolase genes from Clostridium acetobutylicum DSM 792
    • Winzer K., Lorenz K., Zickner B., Durre P. Differential regulation of two thiolase genes from Clostridium acetobutylicum DSM 792. J. Mol. Microbiol. Biotechnol. 2000, 2:531-541.
    • (2000) J. Mol. Microbiol. Biotechnol. , vol.2 , pp. 531-541
    • Winzer, K.1    Lorenz, K.2    Zickner, B.3    Durre, P.4
  • 50
    • 84856564793 scopus 로고    scopus 로고
    • Effects of ptb knockout on butyric acid fermentation by Clostridium tyrobutyricum
    • Zhang Y., Yu M., Yang S.T. Effects of ptb knockout on butyric acid fermentation by Clostridium tyrobutyricum. Biotechnol. Prog. 2012, 28:52-59.
    • (2012) Biotechnol. Prog. , vol.28 , pp. 52-59
    • Zhang, Y.1    Yu, M.2    Yang, S.T.3
  • 51
    • 12244288341 scopus 로고    scopus 로고
    • Intracellular butyryl phosphate and acetyl phosphate concentrations in Clostridium acetobutylicum and their implications for solvent formation
    • Zhao Y., Tomas C.A., Rudolph F.B., Papoutsakis E.T., Bennett G.N. Intracellular butyryl phosphate and acetyl phosphate concentrations in Clostridium acetobutylicum and their implications for solvent formation. Appl. Environ. Microbiol. 2005, 71:530-537.
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 530-537
    • Zhao, Y.1    Tomas, C.A.2    Rudolph, F.B.3    Papoutsakis, E.T.4    Bennett, G.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.