Discovery of anthranilamides as a novel class of inhibitors of neurotropic alphavirus replication

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 7, 2015, Pages 1569-1587

  Barraza, Scott J ^a   Delekta, Philip C ^b   Sindac, Janice A ^a   Dobry, Craig J ^b   Xiang, Jianming ^b   Keep, Richard F ^b   Miller, David J ^b   Larsen, Scott D ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Drug development; Medicinal chemistry; Virology

Indexed keywords

1 (4 CHLOROBENZOYL)PYRROLIDINE 2 CARBOXYLIC ACID; 1 (4 CHLOROBENZYL)PYRROLIDINE 2 CARBOXYLIC ACID; 1 (6 CHLORO 9H CARBAZOLE 1 CARBONYL) N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 (9H CARBAZOLE 1 CARBONYL) N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [1 (4 CHLOROBENZOYL)PYRROLIDINE 2 CARBONYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [1 (4 CHLOROBENZYL) 1H PYRROLE 2 CARBONYL] N [2 (PYRIDIN 4 YL)ETHYL]AZETIDINE 3 CARBOXAMIDE; 1 [1 (4 CHLOROBENZYL) 2 OXO 1,2 DIHYDROQUINOLIN 4 YL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [1 (4 CHLOROBENZYL)PYRROLIDINE 2 CARBONYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [1 (4 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 4 YL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [2 (4 CHLOROBENZOYL)BENZOYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [2 (4 CHLOROBENZYL)BENZOYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [2 (4 CHLOROPHENOXY)BENZOYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [2 (4 CHLOROPHENYL)ACETYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [2 (BENZYLAMINO)BENZOYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [2 (PHENYLAMINO)BENZOYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [2 [(4 CHLOROBENZYL)AMINO]BENZOYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [2 [(4 CHLOROPHENETHYL)AMINO]BENZOYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [2 [(4 CHLOROPHENYL)(METHYL)AMINO]BENZOYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [2 [(4 CHLOROPHENYL)AMINO]BENZOYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 1 [3 (4 CHLOROPHENYL)PROPANOYL] N [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 4 CARBOXAMIDE; 2 AMINOBENZAMIDE; ETHYL 1 [(4 CHLOROBENZYL)CARBAMOYL]PIPERIDINE 4 CARBOXYLIC ACID; ETHYL 1 [1 (4 CHLOROBENZOYL)PYRROLIDINE 2 CARBONYL]PIPERIDINE 4 CARBOXYLIC ACID; ETHYL 1 [2 (4 CHLOROPHENYL)ACETYL]PIPERIDINE 4 CARBOXYLIC ACID; ETHYL 1 [3 (4 CHLOROPHENYL)PROPANOYL]PIPERIDINE 4 CARBOXYLIC ACID; METHYL 1 [1 (4 CHLOROBENZYL) 1H PYRROLE 2 CARBONYL]AZETIDINE 3 CARBOXYLIC ACID; METHYL 2 (4 CHLOROPHENOXY)BENZOIC ACID; METHYL 2 [(4 CHLOROPHENYL)AMINO]BENZOIC ACID; N1 (4 CHLOROBENZYL) N4 [2 (PYRIDIN 4 YL)ETHYL]PIPERIDINE 1,4 DICARBOXAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTHRANILIC ACID DERIVATIVE; ANTIVIRUS AGENT;

ALPHA VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CALIFORNIA ENCEPHALITIS VIRUS; CONTROLLED STUDY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; ENCEPHALOMYOCARDITIS VIRUS; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; VENEZUELAN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS; VIRUS REPLICATION; ALPHAVIRUS; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; LIVER MICROSOME; PHYSIOLOGY; PROCEDURES; VIROLOGY;

ALPHAVIRUS; ANIMALS; ANTIVIRAL AGENTS; DRUG DISCOVERY; MICE; MICE, INBRED BALB C; MICROSOMES, LIVER; ORTHO-AMINOBENZOATES; VIRUS REPLICATION;

EID: 84925497558     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.01.054     Document Type: Article

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