Novel inhibitors of neurotropic alphavirus replication that improve host survival in a mouse model of acute viral encephalitis

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3535-3545

  Sindac, Janice A ^a   Yestrepsky, Bryan D ^a   Barraza, Scott J ^a   Bolduc, Kyle L ^a   Blakely, Pennelope K ^c   Keep, Richard F ^b   Irani, David N ^c   Miller, David J ^b   Larsen, Scott D ^a  

^a Department of Pharmaceutical Sciences   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [1 (4 CHLOROBENZYL) 1H INDOLE 2 CARBONYL] N (1 PHENYLETHYL)PIPERIDINE 4 CARBOXAMIDE; ANTIVIRUS AGENT; CCG 203926; INDOLE DERIVATIVE; N BENZYL 1 [1 (4 CHLOROBENZYL) 1H INDOLE 2 CARBONYL]PIPERIDINE 4 CARBOXAMIDE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARBOVIRUS; ARTICLE; CELL CULTURE; CHIRALITY; CONTROLLED STUDY; CYTOTOXICITY; DISEASE MODEL; DRUG METABOLISM; DRUG STABILITY; ENANTIOSELECTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME METABOLISM; MOUSE; NEUROTROPISM; NONHUMAN; OUTCOME ASSESSMENT; SURVIVAL; VIRUS ENCEPHALITIS; VIRUS REPLICATION; WESTERN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS;

ACUTE DISEASE; ALPHAVIRUS; ALPHAVIRUS INFECTIONS; ANIMALS; ANTIVIRAL AGENTS; BRAIN; CELL SURVIVAL; ENCEPHALITIS, VIRAL; INDOLES; MEMBRANES, ARTIFICIAL; MICE; MICROSOMES, LIVER; NEURONS; PERMEABILITY; PIPERIDINES; PYRROLES; REPLICON; SPINAL CORD; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; VIRAL TROPISM; VIRUS REPLICATION;

EID: 84859802582     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300214e     Document Type: Article

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