Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer

Breast Cancer Research and Treatment

Volumn 149, Issue 1, 2015, Pages 59-67

  Alshaker, Heba ^a,b   Wang, Qi ^c   Frampton, Adam E ^a   Krell, Jonathan ^a   Waxman, Jonathan ^a   Winkler, Mathias ^a   Stebbing, Justin ^a   Cooper, Colin ^c   Yagüe, Ernesto ^a   Pchejetski, Dmitri ^c  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF PETRA   (Jordan)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Adipokine; Breast cancer; IL 6; Obesity; Sphingosine; STAT3

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; LEPTIN; NEUTRALIZING ANTIBODY; SMALL INTERFERING RNA; SPHINGOSINE KINASE 1; STAT3 PROTEIN; ESTROGEN RECEPTOR; LEPTIN RECEPTOR; PHOSPHOTRANSFERASE; SPHINGOSINE KINASE; STAT3 PROTEIN, HUMAN;

ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; ESTROGEN RECEPTOR NEGATIVE BREAST CANCER; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; ISOTOPE LABELING; LYMPH NODE METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; WESTERN BLOTTING; BIOSYNTHESIS; BREAST TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; PHOSPHORYLATION; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CYTOKINE RECEPTOR GP130; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERLEUKIN-6; LEPTIN; LYMPHATIC METASTASIS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, ESTROGEN; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION;

EID: 84925489396     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-014-3228-8     Document Type: Article

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