Phosphate Binders Prevent Phosphate-Induced Cellular Senescence of Vascular Smooth Muscle Cells and Vascular Calcification in a Modified, Adenine-Based Uremic Rat Model

Calcified Tissue International

Volumn 96, Issue 4, 2015, Pages 347-358

  Yamada, S ^a,b   Tatsumoto, N ^a   Tokumoto, M ^b   Noguchi, H ^a   Ooboshi, H ^b   Kitazono, T ^a   Tsuruya, K ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b FUKUOKA DENTAL COLLEGE   (Japan)

Author keywords

Calcium carbonate; Cellular senescence; Chronic kidney disease; Phosphate; Phosphate binder; Vascular calcification; Vascular smooth muscle cell

Indexed keywords

ADENINE; BETA GALACTOSIDASE; CALCIUM; CALCIUM CARBONATE; FIBROBLAST GROWTH FACTOR 23; LANTHANUM CARBONATE; MAGNESIUM; OSTEOCALCIN; PHOSPHATE; PROTEIN P16; PROTEIN P21; TRANSCRIPTION FACTOR RUNX2; LANTHANUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTERY CALCIFICATION; ARTICLE; CALCIUM EXCRETION; CELL AGING; CELL TRANSDIFFERENTIATION; CELLULAR SENESCENCE; CONTROLLED STUDY; KIDNEY FAILURE; MAGNESIUM EXCRETION; MALE; NONHUMAN; OXIDATIVE STRESS; PHOSPHATE EXCRETION; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; RAT MODEL; SENESCENCE; SPRAGUE DAWLEY RAT; SURVIVAL RATE; UREMIA; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; ANIMAL FOOD; BLOOD VESSEL CALCIFICATION; CALCINOSIS; CHEMISTRY; CYTOLOGY; DISEASE COURSE; DISEASE MODEL; DRUG EFFECTS; FIBROSIS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY; KIDNEY FAILURE, CHRONIC; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ADENINE; ANIMAL FEED; ANIMALS; CALCINOSIS; CALCIUM CARBONATE; CELL AGING; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FIBROSIS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY; KIDNEY FAILURE, CHRONIC; LANTHANUM; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OXIDATIVE STRESS; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; UREMIA; VASCULAR CALCIFICATION;

EID: 84925487825     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-014-9929-5     Document Type: Article

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