High phosphate feeding induced arterial medial calcification in uremic rats: Roles of Lanthanum carbonate on protecting vasculature

Life Sciences

Volumn 93, Issue 17, 2013, Pages 646-653

  Yu, Che ^a   Chen, Bing ^a   Zhao, Tingting ^b   Wang, Rong ^a   Akhtar, Javed ^a   Wang, Haiping ^a   Zhang, Hong ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b Shandong Provincial Chest Hospital   (China)

Author keywords

Arterial medial calcification; Chronic renal failure; FGF 23; Hyperphosphatemia; Klotho; Lanthanum carbonate

Indexed keywords

CALCIUM; COLLAGEN TYPE 2; CORTICOTROPIN RELEASING FACTOR; CREATININE; FIBROBLAST GROWTH FACTOR 23; LANTHANUM CARBONATE; OSTEOCALCIN; PARATHYROID HORMONE; PHOSPHATE; TRANSCRIPTION FACTOR RUNX2; BONE SIALOPROTEIN; FIBROBLAST GROWTH FACTOR; IBSP PROTEIN, RAT; LANTHANUM; OSTERIX PROTEIN, RAT; PHOSPHATE INTAKE; RUNX2 PROTEIN, RAT; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CALCIFICATION; ARTICLE; CALCIUM BLOOD LEVEL; CARTILAGE CELL; CELL DIFFERENTIATION; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HYPERPHOSPHATEMIA; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OSTEOBLAST; PHENOTYPE; PHOSPHATE BLOOD LEVEL; PHOSPHATE METABOLISM; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UREMIA; VASCULAR SMOOTH MUSCLE; ANIMAL; BIOSYNTHESIS; BLOOD; CALCINOSIS; COMPLICATION; DOWN REGULATION; DRUG EFFECTS; PATHOLOGY; PHOSPHATE INTAKE; TUNICA MEDIA;

RATTUS;

ANIMALS; CALCINOSIS; COLLAGEN TYPE II; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DOWN-REGULATION; FIBROBLAST GROWTH FACTORS; HYPERPHOSPHATEMIA; INTEGRIN-BINDING SIALOPROTEIN; LANTHANUM; MALE; OSTEOCALCIN; PHOSPHATES; PHOSPHORUS, DIETARY; RATS; TRANSCRIPTION FACTORS; TUNICA MEDIA; UREMIA;

EID: 84885174620     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.08.013     Document Type: Article

References (31)

1. W. Bi, J.M. Deng, Z. Zhang, R.R. Behringer, and B. de Crombrugghe Sox9 is required for cartilage formation Nat Genet 22 1999 85 89 [PubMed: 10319868]
2. I.H.d. Boer, T.C. Rue, and B. Kestenbaum Serum phosphorus concentrations in the third National Health and Nutrition Examination Survey (NHANES III) Am J Kidney Dis 53 2009 399 407 [PubMed: 18992979]
3. P. Ciceri, E. Volpi, I. Brenna, L. Arnaboldi, L. Neri, and D. Brancaccio Combined effects of ascorbic acid and phosphate on rat VSMC osteoblastic differentiation Nephrol Dial Transplant 27 2012 122 127 [PubMed: 21613385]
4. M. Cozzolino, E. Bruschetta, D. Cusi, E. Montanari, M.E. Giovenzana, and A. Galassi Phosphate handling in CKD-MBD from stage 3 to dialysis and the three strengths of lanthanum carbonate Expert Opin Pharmacother 13 2012 2337 2353 [PubMed: 23033914]
5. L.L. Demer, and Y. Tintut Vascular calcification: pathobiology of a multifaceted disease Circulation 117 2008 2938 2948 [PubMed: 18519861]
6. D.E. Fair, M.R. Ogborn, H.A. Weiler, N. Bankovic-Calic, E.P. Nitschmann, and S.C. Fitzpatrick-Wong Dietary soy protein attenuates renal disease progression after 1 and 3 weeks in Han:SPRD-cy weanling rats J Nutr 134 2004 1504 1507 [PubMed: 15173419]
7. E. Gonzalez-Parra, M.L. Gonzalez-Casaus, A. Galán, A. Martinez-Calero, V. Navas, and M. Rodriguez Lanthanum carbonate reduces FGF23 in chronic kidney disease Stage 3 patients Nephrol Dial Transplant 26 2011 2567 2571 [PubMed: 21436379]
8. O.M. Gutiérrez, M. Mannstadt, T. Isakova, J.A. Rauh-Hain, H. Tamez, and A. Shah Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis N Engl J Med 359 2008 584 592 [PubMed: 18687639]
9. M.C. Hu, M. Shi, J. Zhang, H. Quiñones, C. Griffith, and M. Kuro-o Klotho deficiency causes vascular calcification in chronic kidney disease J Am Soc Nephrol 22 2011 124 136 [PubMed: 21115613]
10. A.J. Hutchison, M.E. Barnett, R. Krause, J.T.C. Kwan, and G.A. Siami Long-term efficacy and safety profile of lanthanum carbonate: results for up to 6 years of treatment Nephron Clin Pract 110 2008 c15 c23 [PubMed: 18667837]
11. T. Isakova, O. Gutierrez, A. Shah, L. Castaldo, J. Holmes, and H. Lee Postprandial mineral metabolism and secondary hyperparathyroidism in early CKD J Am Soc Nephrol 19 2008 615 623 [PubMed: 18216315]
12. N. Ito, S. Fukumoto, Y. Takeuchi, S. Takeda, H. Suzuki, and T. Yamashita Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in humans J Bone Miner Metab 25 2007 419 422 [PubMed: 17968495]
13. M. Kawai, S. Kinoshita, A. Kimoto, Y. Hasegawa, K. Miyagawa, and M. Yamazaki FGF23 suppresses chondrocyte proliferation in the presence of soluble α-Klotho both in vitro and in vivo J Biol Chem 288 2013 2414 2427 [PubMed: 23235154]
14. T. Kawata, Y. Imanishi, K. Kobayashi, T. Miki, A. Arnold, and M. Inaba Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism J Am Soc Nephrol 18 2007 2683 2688 [PubMed: 17855636]
15. K. Lim, T.-S. Lu, G. Molostvov, C. Lee, D. Zehnder, and L.-L. Hsiao Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23 Circulation 125 2012 2243 2255 [PubMed: 22492635]
16. G.M. London, S.J. Marchais, A.P. Guérin, and F. Métivier Impairment of arterial function in chronic renal disease: prognostic impact and therapeutic approach Nephrol Dial Transplant 17 2002 13 15 [PubMed: 12386250]
17. D. Magne, M. Julien, C. Vinatier, F. Merhi-Soussi, P. Weiss, and J. Guicheux Cartilage formation in growth plate and arteries: from physiology to pathology Bioessays 27 2005 708 716 [PubMed: 15954094]
18. K.J. Martin, and E.A. González Prevention and control of phosphate retention/hyperphosphatemia in CKD-MBD: what is normal, when to start, and how to treat? Clin J Am Soc Nephrol 6 2011 440 446 [PubMed: 21292848]
19. S.M. Moe, N.X. Chen, M.F. Seifert, R.M. Sinders, D. Duan, and X. Chen A rat model of chronic kidney disease-mineral bone disorder Kidney Int 75 2009 176 184 [PubMed: 18800026]
20. N. Nagano, S. Miyata, M. Abe, N. Kobayashi, S. Wakita, and T. Yamashita Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats Kidney Int 69 2006 531 537 [PubMed: 16395276]
21. E. Neven, V. Persy, S. Dauwe, T.D. Schutter, M.E.D. Broe, and P.C. D'Haese Chondrocyte rather than osteoblast conversion of vascular cells underlies medial calcification in uremic rats Arterioscler Thromb Vasc Biol 30 2010 1741 1750 [PubMed: 20522801]
22. T. Orfanidou, D. Iliopoulos, K.N. Malizos, and A. Tsezou Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes J Cell Mol Med 13 2009 3186 3194 [PubMed: 20196777]
23. A. Pai, E.M. Leaf, M. El-Abbadi, and C.M. Giachelli Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease Am J Pathol 178 2011 764 773 [PubMed:21281809]
24. V. Shalhoub, E.M. Shatzen, S.C. Ward, J. Davis, J. Stevens, and V. Bi FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality J Clin Invest 122 2012 2543 2553 [PubMed: 22728934]
25. C.M. Shanahan, M.H. Crouthamel, A. Kapustin, and C.M. Giachelli Arterial calcification in chronic kidney disease: key roles for calcium and phosphate Circ Res 109 2011 697 711 [PubMed: 21885837]
26. T. Shigematsu, S. Negi, and Group CR Combined therapy with lanthanum carbonate and calcium carbonate for hyperphosphatemia decreases serum FGF-23 level independently of calcium and PTH (COLC Study) Nephrol Dial Transplant 27 2012 1050 1054 [PubMed: 21771755]
27. R.C. Shroff, R. McNair, N. Figg, J.N. Skepper, L. Schurgers, and A. Gupta Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis Circulation 118 2008 1748 1757 [PubMed: 18838561]
28. S.M. Sprague, H. Abboud, P. Qiu, M. Dauphin, P. Zhang, and W. Finn Lanthanum carbonate reduces phosphorus burden in patients with CKD stages 3 and 4: a randomized trial Clin J Am Soc Nephrol 4 2009 178 185 [PubMed: 19056618]
29. M. Tonelli, N. Pannu, and B. Manns Oral phosphate binders in patients with kidney failure N Engl J Med 362 2010 1312 1324 [PubMed: 20375408]
30. H. Wang, Y. Yoshiko, R. Yamamoto, T. Minamizaki, K. Kozai, and K. Tanne Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro J Bone Miner Res 23 2008 939 948 [PubMed: 18282132]
31. C.A. Yoshida, H. Komori, Z. Maruyama, T. Miyazaki, K. Kawasaki, and T. Furuichi SP7 inhibits osteoblast differentiation at a late stage in mice PLoS One 7 2012 e32364 [PubMed: 22396760]