2-Benzisothiazolylimino-5-benzylidene-4-thiazolidinones as protective agents against cartilage destruction

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 7, 2015, Pages 1551-1556

  Crascì, Lucia ^a   Vicini, Paola ^b   Incerti, Matteo ^b   Cardile, Venera ^a   Avondo, Sergio ^a   Panico, Annamaria ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

Chondroprotective activity; Glycosaminoglycans; Metalloproteinase 13; Metalloproteinase 3; ORAC; Thiazolidinones

Indexed keywords

2 (BENZO[D]ISOTHIAZOL 3 YLIMINO) 5 (2 HYDROXYBENZYLIDENE)THIAZOLIDIN 4 ONE; 2 (BENZO[D]ISOTHIAZOL 3 YLIMINO) 5 (3 HYDROXYBENZYLIDENE)THIAZOLIDIN 4 ONE; 2 BENZO[D]ISOTHIAZOLYLIMINO 5 BENZYLIDENE 4 THIAZOLIDINONE DERIVATIVE; 4 THIAZOLIDINONE DERIVATIVE; COLLAGENASE 3; GLYCOSAMINOGLYCAN; HYDROXAMIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; N ISOBUTYL N [4 METHOXYPHENYLSULFONYL] GLYCYLHYDROXAMIC ACID; NITRIC OXIDE; STROMELYSIN; UNCLASSIFIED DRUG; PROTECTIVE AGENT; THIAZOLIDINE DERIVATIVE;

ANTIOXIDANT ACTIVITY; ARTICLE; CARTILAGE DEGENERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; OSTEOARTHRITIS; PROTEIN EXPRESSION; PROTEIN SECRETION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; WESTERN BLOTTING; CARTILAGE; CARTILAGE CELL; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PATHOLOGY;

CARTILAGE; CELLS, CULTURED; CHONDROCYTES; HUMANS; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; OSTEOARTHRITIS; PROTECTIVE AGENTS; THIAZOLIDINES;

EID: 84925483397     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.02.002     Document Type: Article

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