Benzisothiazolyliminothiazolidin-4-ones with Chondroprotective Properties: Searching for Potent and Selective Inhibitors of MMP-13

ChemMedChem

Volumn 6, Issue 7, 2011, Pages 1199-1202

  Vicini, Paola ^a   Crascì, Lucia ^b   Incerti, Matteo ^a   Ronsisvalle, Simone ^b   Cardile, Venera ^b   Panico, Anna Maria ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

Heterocycles; Matrix metalloproteinases; Molecular modeling; Osteoarthritis; Substituent effects

Indexed keywords

2 (BENZO[D]ISOTHIAZOL 3 YLIMINO)THIAZOLIDIN 4 ONE; CHONDROPROTECTIVE AGENT; COLLAGENASE 3; FREE RADICAL; GLYCOSAMINOGLYCAN; INTERLEUKIN 1BETA; METALLOPROTEINASE INHIBITOR; NITRIC OXIDE; UNCLASSIFIED DRUG; ZINC;

ANTIOXIDANT ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CARTILAGE CELL; CELL VIABILITY; CHONDROPROTECTION; DRUG SYNTHESIS; HUMAN; HYDROLYSIS; METAL BINDING; MOLECULAR DOCKING; OSTEOARTHRITIS; OXIDATIVE STRESS; PRIORITY JOURNAL; RADICAL REACTION;

BINDING SITES; COMPUTER SIMULATION; HUMANS; MATRIX METALLOPROTEINASE 13; MODELS, MOLECULAR; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIAZOLIDINES;

EID: 79959748949     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100223     Document Type: Article

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