The use of 18F-BCPP-EF as a PET probe for complex i activity in the brain

Methods in Enzymology

Volumn 547, Issue C, 2014, Pages 417-431

  Tsukada, Hideo ^a  

^a CENTRAL RESEARCH LABORATORY   (Japan)

Author keywords

Aging; Brain; Ischemia; Mitochondria; Parkinson; PET

Indexed keywords

AMYLOID BETA PROTEIN; BCPP EF F 18; PYRIDAZINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG; 2-TERT-BUTYL-4-CHLORO-5-(6-(2-(2-FLUOROETHOXY)ETHOXY)PYRIDIN-3-YLMETHOXY)-2H-PYRIDAZIN-3-ONE; MOLECULAR PROBE; PYRIDINE DERIVATIVE; ROTENONE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN REGION; CEREBROVASCULAR ACCIDENT; COMPLEX I DEFICIENCY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME ACTIVITY; GROUPS BY AGE; ISOTOPE LABELING; MACACA FASCICULARIS; MALE; NEUROIMAGING; NEUROMONITORING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN FUNCTION; RAT; TISSUE SPECIFICITY; TISSUE STRUCTURE; ANIMAL; CHEMISTRY; DIAGNOSTIC USE; DRUG DESIGN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; METABOLISM; MOLECULAR PROBE; PATHOLOGY; PHARMACOKINETICS; PROCEDURES; SPRAGUE DAWLEY RAT;

ANIMALIA;

AGING; AMYLOID BETA-PEPTIDES; ANIMALS; DRUG DESIGN; ELECTRON TRANSPORT COMPLEX I; HYPOXIA-ISCHEMIA, BRAIN; MACACA FASCICULARIS; MALE; MOLECULAR PROBES; POSITRON-EMISSION TOMOGRAPHY; PYRIDAZINES; PYRIDINES; RATS, SPRAGUE-DAWLEY; ROTENONE; STROKE;

EID: 84925446801     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-801415-8.00020-5     Document Type: Chapter

References (27)

1. P.J. Boyle, J.C. Scott, A.J. Krentz, R.J. Nagy, E. Comstock, and C. Hoffman Diminished brain glucose metabolism is a significant determinant for falling rates of systemic glucose utilization during sleep in normal humans Journal of Clinical Investigation 93 1994 529 535
2. A. Bratic, and N.G. Larsson The role of mitochondria in aging Journal of Clinical Investigation 123 2013 952 957
3. E. Cadenas, A. Boveris, C.I. Ragan, and A.O.M. Stoppani Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinl-cytochrome c reductase from beef-heart mitochondria Archives of Biochemistry and Biophysics 180 1977 248 257
4. 2-dopamine receptors studied by PET - A comparison to the equilibrium analysis Journal of Cerebral Blood Flow and Metabolism 9 1989 696 708
5. 11C]BCPP-EM for mitochondrial complex I imaging Journal of Labelled Compounds & Radiopharmaceuticals 56 2013 553 561
6. A.H. Jacobs, B. Tavitian, and INMiND consortium Noninvasive molecular imaging of neuroinflammation Journal of Cerebral Blood Flow and Metabolism 32 2012 1393 1415
7. E.G. Jones, J.M. Stone, and H.J. Karten High-resolution digital brain atlases: A Hubble telescope for the brain Annals of the New York Academy of Sciences 1225 2011 E147 E159
8. 11C-methyl]-(-)-cocaine PET studies in human subjects Journal of Cerebral Blood Flow and Metabolism 10 1990 740 747
9. M. Manczak, Y. Jung, B.S. Park, D. Partovi, and P.H. Reddy Time-course of mitochondrial gene expressions in mice brains: Implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging Journal of Neurochemistry 92 2005 494 504
10. T. Mizuta, K. Kitamura, H. Iwata, Y. Yamagishi, A. Ohtani, and K. Tanaka Performance evaluation of a high-sensitivity large-aperture small-animal PET scanner: ClairvivoPET Annals of Nuclear Medicine 22 2008 447 455
11. A. Navarro, and A. Boveris The mitochondrial energy transduction system and the aging process American Journal of Physiology - Cell Physiology 292 2007 C670 C686
12. J. Ojaimi, C.L. Masters, K. Opeskin, P. McKelvie, and E. Byrne Mitochondrial respiratory chain activity in the human brain as a function of age Mechanisms of Ageing and Development 111 1999 39 47
13. 2 + rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration Journal of Biological Chemistry 278 2003 25454 25460
14. 18F]FDG-PET study Journal of Cerebral Blood Flow and Metabolism 29 2009 1216 1225
15. H. Takamatsu, H. Tsukada, T. Kakiuchi, S. Nishiyama, A. Noda, and K. Umemura Detection of reperfusion injury using positron emission tomography in a monkey model of cerebral ischemia Journal of Nuclear Medicine 41 2000 1409 1416
16. H. Tsukada Animal PET research with non-human primate for drug development in pre-clinical stage - The Hamamatsu experience P.H. Elsinger, A. van Waarde, A.M.J. Paans, R.A.J.O. Dierckx, Trends on the role of PET in drug development 2012 World Scientific New Jersey 241 259
17. H. Tsukada PET imaging of muscarinic receptors R.A.J.O. Dierckx, A. Otte, E.F.J. de Vries, A. van Waarde, P.G.M. Luiten, PET and SPECT of neurobiological systems 2014 Springer-Verlag Heidelberg 445 464
18. 18F-BMS-747158-02 in rat brain Journal of Nuclear Medicine 55 2014 473 480
19. H. Tsukada, S. Nishiyama, H. Ohba, M. Kanazawa, T. Kakiuchi, and N. Harada Comparing amyloid-β deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: A PET study in aged monkeys European Journal of Nuclear Medicine and Molecular Imaging 41 2014 2127 2136
20. 18F-BCPP-EF for mitochondrial complex I imaging in conscious monkey brain using PET European Journal of Nuclear Medicine and Molecular Imaging 41 2014 755 763
21. H. Tsukada, H. Ohba, S. Nishiyama, M. Kanazawa, T. Kakiuchi, and N. Harada PET imaging of ischemia-induced impairment of mitochondrial complex I function in monkey brain Journal of Cerebral Blood Flow and Metabolism 34 2014 708 714
22. K. Umemura, K. Wada, T. Uematsu, and M. Nakashima Evaluation of the combination of a tissue-type plasminogen activator, SUN9216, and a thromboxane A2 receptor antagonist, vapiprost, in a rat middle cerebral artery thrombosis model Stroke 24 1993 1077 1082
23. M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: The metabolic requirements of cell proliferation Science 324 2009 1029 1033
24. O. Warburg On respiratory impairment in cancer cells Science 124 1956 269 270
25. M. Watanabe, H. Okada, K. Shimizu, T. Omura, E. Yoshikawa, and T. Kosugi A high resolution animal PET scanner using compact PS-PMT detectors IEEE Transactions on Nuclear Science 44 1997 1277 1282
26. R.N. Waterhouse Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents Molecular Imaging and Biology 5 2003 376 389
27. P. Yalamanchili, E. Wexler, M. Hayes, M. Yu, J. Bozek, and M. Kagan Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: A novel PET myocardial imaging agent Journal of Nuclear Cardiology 14 2007 782 788