Vitamin D/VDR signaling pathway ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced colitis by inhibiting intestinal epithelial apoptosis

International Journal of Molecular Medicine

Volumn 35, Issue 5, 2015, Pages 1213-1218

  Zhu, Tong ^a   Liu, Tian Jing ^a   Shi, Yong Yan ^a   Zhao, Qun ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

2,4,6 trinitrobenzene sulfonic acid; Apoptosis; Inflammatory bowel disease; P53 upregulated modulator of apoptosis; Vitamin D; Vitamin D receptor

Indexed keywords

25 HYDROXYVITAMIN D; CASPASE 3; INTERLEUKIN 17; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PARICALCITOL; PROTEIN P53; PUMA PROTEIN; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; VITAMIN D; VITAMIN D RECEPTOR; AUTACOID; CALCITRIOL RECEPTOR; CYTOKINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG MECHANISM; EXPERIMENTAL COLITIS; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; MALE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; SIGNAL TRANSDUCTION; ULCERATIVE COLITIS; WEIGHT REDUCTION; ANIMAL; CASE CONTROL STUDY; CHEMICALLY INDUCED; COLITIS; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATORY BOWEL DISEASE; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PERMEABILITY;

ANIMALS; APOPTOSIS; CASE-CONTROL STUDIES; COLITIS; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MALE; MICE; PERMEABILITY; RECEPTORS, CALCITRIOL; SIGNAL TRANSDUCTION; TRINITROBENZENESULFONIC ACID; VITAMIN D;

EID: 84925444547     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2150     Document Type: Article

References (31)

1. Tan B, Li P, Lv H, et al: Vitamin D Levels and bone metabolism in Chinese adult patients with infammatory bowel disease. J Dig Dis 15:116-123, 2014.
2. Levin AD, Wadhera V, Leach ST, et al: Vitamin D deficiency in children with infammatory bowel disease. Dig Dis Sci 56:830-836, 2011.
3. Loftus EV Jr: Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 126:1504-1517, 2004.
4. Wang L, Wang ZT, Hu JJ, Fan R, Zhou J and Zhong J: Polymorphisms of the vitamin D receptor gene and the risk of infammatory bowel disease: a meta-analysis. Genet Mol Res 13:2598-2610, 2014.
5. Xue LN, Xu KQ, Zhang W, Wang Q, Wu J and Wang XY: Associations between vitamin D receptor polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a metaanalysis. Inflamm Bowel Dis 19:54-60, 2013.
6. Kong J, Zhang ZY, Musch M W, et al: Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol 294:208-216, 2008.
7. Peterson LW and Artis D: Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol 14:141-153, 2014.
8. Fasano A and Shea-Donohue T: Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol 2:416-422, 2005.
9. Gibson PR: Increased gut permeability in Crohn's disease: is TNF the link? Gut 53:1724-1725, 2004.
10. Watson AJ, Chu S, Sieck L, et al: Epithelial bar rier function in vivo is sustained despite gaps in epithelial layers. Gastroenterology 129:902-912, 2005.
11. Abraham C and Cho JH: Infammatory bowel disease. N Engl J Med 361:2066-2078, 2009.
12. Su L, Nalle SC, Shen L, et al: TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology 145:407-415, 2013.
13. Liu W, Chen Y, Golan MA, et al: Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis. J Clin Invest 123:3983-3996, 2013.
14. Dirisina R, Katzman RB, Goretsky T, et al: p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. Gastroenterology 141:1036-1045, 2011.
15. Qiu W, Wu B, Wang X, et al: PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. J Clin Invest 121:1722-1732, 2011.
16. Bouillon R, Carmeliet G, Verlinden L, et al: Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29:726-776, 2008.
17. Wirtz S, Neufert C, Weigmann B and Neurath MF: Chemically induced mouse models of intestinal inflammation. Nat Protoc 2:541-546, 2007.
18. Appleyard CB and Wallace JL: Reactivation of hapten-induced colitis and its prevention by anti-inflammatory drugs. Am J Physiol 269:G119-G125, 1995.
19. Cheng S and Coyne D: Paricalcitol capsules for the control of secondary hyperparathyroidism in chronic kidney disease. Expert Opin Pharmacother 7:617-621, 2006.
20. Greenbaum LA, Benador N, Goldstein SL, et al: Intravenous paricalcitol for treatment of secondary hyperparathyroidism in children on hemodialysis. Am J Kidney Dis 49:814-823, 2007.
21. Harries AD, Brown R, Heatley RV, Williams LA, Woodhead S and Rhodes J: Vitamin D status in Crohn's disease: association with nutrition and disease activity. Gut 26:1197-1203, 1985.
22. Moum B, Aadland E, Ekbom A and Vatn MH: Seasonal variations in the onset of ulcerative colitis. Gut 38:376-378, 1996.
23. Naderi N, Farnood A, Habibi M, et al: Association of vitamin D receptor gene polymorphisms in Iranian patients with infammatory bowel disease. J Gastroenterol Hepatol 23:1816-1822, 2008.
24. Cutolo M, Paolino S, Sulli A, Smith V, Pizzorni C and Seriolo B: Vitamin D, steroid hormones, and autoimmunity. Ann NY Acad Sci 1317:39-46, 2014.
25. Cantorna MT, McDaniel K, Bora S, Chen J and James J: Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease. Exp Biol Med 239:1524-1530, 2014.
26. Cantorna MT and Mahon BD: Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood) 229:1136-1142, 2004.
27. Froicu M, Zhu Y and Cantorna MT: Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice. Immunology 117:310-318, 2006.
28. Nicholson I, Dalzell AM and El-Matary W: Vitamin D as a therapy for colitis: a systematic review. J Crohns Colitis 6:405-411, 2012.
29. Han J, Flemington C, Houghton AB, et al: Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci USA 98:11318-11323, 2001.
30. Yu J and Zhang L: PUMA, a potent killer with or without p53. Oncogene 27:S71-S83, 2008.
31. Edelblum KL, Yan F, Yamaoka T and Polk DB: Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Infamm Bowel Dis 12:413-424, 2006.