Genistein induces apoptosis by the inactivation of the IGF-1R/p-Akt signaling pathway in MCF-7 human breast cancer cells

Food and Function

Volumn 6, Issue 3, 2015, Pages 995-1000

  Chen, Jun ^a   Duan, Yuxin ^b   Zhang, Xing ^a   Ye, Yu ^c   Ge, Bo ^a   Chen, Jian ^a  

^a GUILIN MEDICAL UNIVERSITY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

^c FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL PROLIFERATION; DISEASES; FLAVONOIDS; FLOW CYTOMETRY; PROTEINS;

BCL-2 AND BAX MRNA; CELL APOPTOSIS; FLOW CYTOMETRY ANALYSIS; HUMAN BREAST CANCER CELLS; MCF-7 HUMAN BREAST CANCER CELLS; MORPHOLOGICAL CHANGES; PROTEIN EXPRESSIONS; SIGNALING PATHWAYS;

CELL SIGNALING;

AKT1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; BCL2 PROTEIN, HUMAN; GENISTEIN; IGF1R PROTEIN, HUMAN; MESSENGER RNA; PHYTOESTROGEN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SOMATOMEDIN RECEPTOR;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; BREAST NEOPLASMS; CELL PROLIFERATION; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MCF 7 CELL LINE; METABOLISM; OSMOLARITY; PATHOLOGY; PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENISTEIN; HUMANS; MCF-7 CELLS; OSMOLAR CONCENTRATION; PHOSPHORYLATION; PHYTOESTROGENS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, SOMATOMEDIN; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84925440338     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c4fo01141d     Document Type: Article

References (22)

1. A. Jemal R. Siegel J. Xu E. Ward Cancer statistics CA-Cancer J. Clin. 2010 60 277 300
2. S. Jin Q. Y. Zhang X. M. Kang J. X. Wang W. H. Zhao Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway Ann. Oncol. 2010 21 263 268
3. H. Adlercreutz Phyto-oestrogens and cancer Lancet Oncol. 2002 3 364 373
4. C. Y. Hsieh R. C. Santell S. Z. Haslam W. G. Helferich Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo Cancer Res. 1998 58 3833 3838
5. M. J. Messina C. L. Loprinzi Soy for breast cancer survivors: a critical review of the literature J. Nutr. 2001 131 3095S 3108S
6. D. A. Clinton F. A. Kimberly H. J. Young T. S. Goeppinger D. R. Doerge W.G Helferich Soy processing influences growth of estrogen-dependent breast cancer tumors Carcinogenesis 2004 25 1649 1657
7. J. Chen L. Liu R. Hou Z. Shao Y. Wu X. Chen et al., Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo Cancer Lett. 2011 308 144 151
8. E. J. Choi G. H. Kim Daidzein causes cell cycle arrest at the G1 and G2/M phases in human breast cancer MCF-7 and MDA-MB-453 cells Phytomedicine 2008 15 683 690
9. A. R. Kennedy H. Manzone Effects of protease inhibitors on levels of proteolytic activity in normal and premalignant cells and tissues J. Cell. Biochem. 1995 Suppl. 22 188 194
10. A. M. Shamsuddin Inositol phosphates have novel anticancer function J. Nutr. 1995 125 725S 732S
11. S. Barnes, C. Grubbs, K. DR. Setchell and J. Carlson, Soybeans inhibit mammary tumors in models of breast cancer, in Mutagens and Carcinogens in the Diet, 1990, pp. 239-253
12. P. Fan S. Fan H. Wang J. Mao Y. Shi M. M. Ibrahim et al., Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway Stem Cell. Res. Ther. 2013 4 6 146
13. V. Phan J. Walters B. Brownlow T. Elbayoumi Enhanced cytotoxicity of optimized liposomal genistein via specific induction of apoptosis in breast, ovarian and prostate carcinomas J. Drug Target 2013 10 1001 1011
14. A. J. Stewart M. D. Johnson F. E. May B. R. Westley Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells J. Biol. Chem. 1990 265 21172 21178
15. S. Zhang X. Li R. Burghardt R. Smith S. H. Safe Role of estrogen receptor (ER) α in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells J. Mol. Endocrinol. 2005 35 433 447
16. N. Reizner S. Maor R. Sarfstein S. Abramovitch W. V. Welshons E. M. Curran et al., The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor- and regulates IGF-I receptor gene transcription in breast cancer cells J. Mol. Endocrinol. 2005 35 135 144
17. S. R. Datta A. Brunet M. E. Greenberg Cellular survival: a play in three Akts Genes Dev. 1999 13 2905 2927
18. S. R. Datta H. Dudek X. Tao S. Masters H. Fu Y. Gotoh et al., Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery Cell 1997 91 231 241
19. G. Del Poeta A. Venditti M. I. Del Principe L. Maurillo F. Buccisano A. Tamburini et al., Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML) Blood 2003 101 2125 2131
20. J. Tian Y. X. Duan C. Y. Bei J. Chen Calycosin induces apoptosis by upregulation of RASD1 in human breast cancer cells MCF-7 Original Basic 2013 593 598
21. J. Chen J. Zeng M. Xin W. Huang X. Chen Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3 K/Akt pathways in vitro and in vivo Original Basic 2011 681 868
22. J. Chen X. Zhao Y. Ye Y. Wang J. Tian Estrogen receptor beta-mediated proliferative inhibition and apoptosis in human breast cancer by calyosin and formononetin Cell Physiol. Biochem. 2013 1790 1797