Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 12, 2015, Pages E1480-E1489

  Claiborne, Daniel T ^a   Prince, Jessica L ^a   Scully, Eileen ^b   Macharia, Gladys ^c   Micci, Luca ^a   Lawson, Benton ^a   Kopycinski, Jakub ^c,d   Deymier, Martin J ^a   Vanderford, Thomas H ^a   Nganou Makamdop, Krystelle ^e   Ende, Zachary ^a   Brooks, Kelsie ^a   Tang, Jianming ^f   Yu, Tianwei ^a   Lakhi, Shabir ^g   Kilembe, William ^g   Silvestri, Guido ^a   Douek, Daniel ^e   Goepfert, Paul A ^f   Price, Matthew A ^h,i   Allen, Susan A ^g,j,k   Paiardini, Mirko ^a   Altfeld, Marcus ^b,l   Gilmour, Jill ^c,d   Hunter, Eric ^a,j   more..

^a EMORY UNIVERSITY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Clinical Immunology   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f University of Alabama at Birmingham   (United States)

^g Zambia Emory HIV Research Project   (Zambia)

^h INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k EMORY UNIVERSITY   (United States)

^l LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

more..

Author keywords

Gag; HIV 1; Immune activation; Pathogenesis; Replicative capacity

Indexed keywords

ALPHA2 INTERFERON; CD38 ANTIGEN; GAG PROTEIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANZYME B; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 7; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

ADAPTIVE IMMUNITY; ALLELE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COHORT ANALYSIS; CORRELATION ANALYSIS; DISEASE COURSE; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 SUBTYPE C; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MEMORY T LYMPHOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROCONVERSION; T LYMPHOCYTE ACTIVATION; VIRUS LOAD; VIRUS REPLICATION; VIRUS TRANSMISSION; ZAMBIAN; BLOOD; CD4 LYMPHOCYTE COUNT; HOMEOSTASIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INFLAMMATION; KAPLAN MEIER METHOD; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; TIME;

HUMAN IMMUNODEFICIENCY VIRUS 1;

CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; CYTOKINES; DISEASE PROGRESSION; FEMALE; HIV INFECTIONS; HIV-1; HOMEOSTASIS; HUMANS; IMMUNOLOGIC MEMORY; INFLAMMATION; KAPLAN-MEIER ESTIMATE; LYMPHOCYTE ACTIVATION; MALE; MOLECULAR SEQUENCE DATA; TIME FACTORS; VIRAL LOAD; VIRUS REPLICATION;

EID: 84925434838     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1421607112     Document Type: Article

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