Effects of levothyroxine replacement therapy on parameters of metabolic syndrome and atherosclerosis in hypothyroid patients: A prospective pilot study

International Journal of Endocrinology

Volumn 2015, Issue , 2015, Pages

  Gluvic, Zoran ^a   Sudar, Emina ^b   Tica, Jelena ^a   Jovanovic, Aleksandra ^b   Zafirovic, Sonja ^b   Tomasevic, Ratko ^a   Isenovic, Esma R ^b  

^a Zemun Clinical Hospital   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEVOTHYROXINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THYROTROPIN; THYROXINE; TRIACYLGLYCEROL;

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; BLOOD FLOW VELOCITY; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; FEMALE; FREE THYROXINE INDEX; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; METABOLIC SYNDROME X; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SUPERFICIAL FEMORAL ARTERY; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION;

EID: 84925433253     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2015/147070     Document Type: Article

References (53)

1. C. Xu, X. Yang, W. Liu et al. , "Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a crosssectional design, " Nutrition and Metabolism, vol. 9, no. 1, article 44, 2012.
2. A. J. Chakera, S. H. S. Pearce, and B. Vaidya, "Treatment for primary hypothyroidism: current approaches and future possibilities, " Drug Design, Development andTherapy, vol. 6, pp. 1-11, 2012.
3. V. Fatourechi, "Subclinical hypothyroidism: an update for primary care physicians, " Mayo Clinic Proceedings, vol. 84, no. 1, pp. 65-71, 2009.
4. M. I. Surks, E. Ortiz, G. H. Daniels et al. , "Subclinical thyroid disease: scientific review and guidelines for diagnosis and management, " Journal of theAmericanMedical Association, vol. 291, no. 2, pp. 228-238, 2004.
5. C. G. P. Roberts and P. W. Ladenson, "Hypothyroidism, " The Lancet, vol. 363, no. 9411, pp. 793-803, 2004.
6. D. Ross, "Subclinical hypothyroidism, " in Werner and Ingbars theThyroid: A Fundamental and Clinical Text, L. E. Braverman and R. D. Utiger, Eds. , pp. 1070-1078, Lippincott Williams and Wilkins, Philadelphia, Pa, USA, 2005.
7. D. S. Cooper, "Subclinical thyroid disease: consensus or conundrum?" Clinical Endocrinology, vol. 60, no. 4, pp. 410-412, 2004.
8. D. S. Cooper, "Subclinical hypothyroidism, " The New England Journal of Medicine, vol. 345, no. 4, pp. 260-265, 2001.
9. A. R. Ayala, M. D. Danese, and P. W. Ladenson, "When to treat mild hypothyroidism, " Endocrinology andMetabolismClinics of North America, vol. 29, no. 2, pp. 399-415, 2000.
10. H. Gharib, R. M. Tuttle, H. J. Baskin, L. H. Fish, P. A. Singer, andM. T. McDermott, "Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society, " Thyroid, vol. 15, no. 1, pp. 24-28, 2005.
11. D. S. Ross, "Serum thyroid-stimulating hormone measurement for assessment of thyroid function and disease, " Endocrinology andMetabolismClinics ofNorthAmerica, vol. 30, no. 2, pp. 245-264, 2001.
12. G. J. Kahaly, "Cardiovascular and atherogenic aspects of subclinical hypothyroidism, " Thyroid, vol. 10, no. 8, pp. 665-679, 2000.
13. M. D. Danese, P. W. Ladenson, C. L. Meinert, and N. R. Powe, "Clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature, " Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 9, pp. 2993-3001, 2000.
14. W. J. Hueston and W. S. Pearson, "Subclinical hypothyroidismand the risk of hypercholesterolemia, " Annals of Family Medicine, vol. 2, no. 4, pp. 351-355, 2004.
15. B. N. Zordoky, I. M. Robertson, and J. R. Dyck, "Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases, " Biochimica et Biophysica Acta, 2014.
16. J. F. Bentzon, F. Otsuka, R. Virmani, and E. Falk, "Mechanisms of plaque formation and rupture, " Circulation Research, vol. 114, no. 12, pp. 1852-1866, 2014.
17. T. R. Vogel, V. Y. Dombrovskiy, E. L. Galinanes, andR. L. Kruse, "Preoperative statins and limb salvage after lower extremity revascularization in the medicare population, " Circulation: Cardiovascular Interventions, vol. 6, no. 6, pp. 694-700, 2013.
18. P. C. G. Simons, A. Algra, M. L. Bots, D. E. Grobbee, and Y. Van Der Graaf, "Common carotid intima-media thickness and arterial stiffness: indicators of cardiovascular risk in high-risk patients: the SMART study (SecondManifestations of ARTerial disease), " Circulation, vol. 100, no. 9, pp. 951-957, 1999.
19. E. Braunwald, A. S. Fauci, D. L. Kasper et al. , Harrisons Principles of Internal Medicine, McGraw-Hill Medical, New York, NY, USA, 15th edition, 2004.
20. M. Imaizumi, M. Akahoshi, S. Ichimaru et al. , "Risk for ischemic heart disease and all-cause mortality in subclinical hypothyroidism, " Journal of Clinical Endocrinology andMetabolism, vol. 89, no. 7, pp. 3365-3370, 2004.
21. C. V. Rizos, M. S. Elisaf, and E. N. Liberopoulos, "Effects of thyroid dysfunction on lipid profile, " Open Cardiovascular Medicine Journal, vol. 5, pp. 76-84, 2011.
22. L. L. Lepsanovic, Klinicka Lipidologija, Savremena Administracija, Beograd, Serbia, 2000.
23. N. J. Stone, "Secondary causes of hyperlipidemia, " Medical Clinics of North America, vol. 78, no. 1, pp. 117-141, 1994.
24. B. C. Tanis, R. G. J. Westendorp, and A. H. M. Smelt, "Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies, " Clinical Endocrinology, vol. 44, no. 6, pp. 643-649, 1996.
25. T. Ichiki, "Thyroid hormone and atherosclerosis, " Vascular Pharmacology, vol. 52, no. 3-4, pp. 151-156, 2010.
26. M. Lu, C. B. Yang, L. Gao, and J. J. Zhao, "Mechanism of subclinical hypothyroidism accelerating endothelial dysfunction (review), " Experimental and Therapeutic Medicine, vol. 9, no. 1, pp. 3-10, 2015.
27. A. E. Hak, H. A. P. Pols, T. J. Visser, H. A. Drexhage, A. Hofman, and J. C. M. Witteman, "Subclinical hypothyroidism is an independent risk factor for atherosclerosis andmyocardial infarction in elderly women: the Rotterdam study, " Annals of Internal Medicine, vol. 132, no. 4, pp. 270-278, 2000.
28. M. D. Cabral, P. F. S. Teixeira, N. A. O. Silva et al. , "Normal flow-mediated vasodilatation of the brachial artery and carotid artery intima-media thickness in subclinical hypothyroidism, " Brazilian Journal ofMedical and Biological Research, vol. 42, no. 5, pp. 426-432, 2009.
29. S. Palomba, P. Affinito, G. A. Tommaselli, and C. Nappi, "A clinical trial of the effects of tibolone administered with gonadotropin-releasing hormone analogues for the treatment of uterine leiomyomata, " Fertility and Sterility, vol. 70, no. 1, pp. 111-118, 1998.
30. S. Palomba, P. Affinito, C. di Carlo, G. Bifulco, and C. Nappi, "Long-term administration of tibolone plus gonadotropinreleasing hormone agonist for the treatment of uterine leiomyomas: effectiveness and effects on vasomotor symptoms, bone mass, and lipid profiles, " Fertility and Sterility, vol. 72, no. 5, pp. 889-895, 1999.
31. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, " Clinical Chemistry, vol. 18, no. 6, pp. 499-502, 1972.
32. H. Harder, B. Dinesen, and A. Astrup, "The effect of a rapid weight loss on lipid profile and glycemic control in obese type 2 diabetic patients, " International Journal of Obesity, vol. 28, no. 1, pp. 180-182, 2004.
33. J. Okecka-Szymanska, E. Hubner-Wozniak, I. Piatkowska, and M. Malara, "Effects of age, gender and physical activity on plasma lipid profile, " Biomedical Human Kinetics, vol. 3, pp. 1-5, 2011.
34. K. S. Stamatelopoulos, K. Kyrkou, E. Chrysochoou et al. , "Arterial stiffness but not intima-media thickness is increased in euthyroid patients with Hashimotos thyroiditis: the effect of menopausal status, " Thyroid, vol. 19, no. 8, pp. 857-862, 2009.
35. R. Jorde, O. Joakimsen, E. Stensland, and E. B. Mathiesen, "Lack of significant association between intima-media thickness in the carotid artery and serum TSH level. The Tromso Study, " Thyroid, vol. 18, no. 1, pp. 21-25, 2008.
36. N. Takamura, A. Akilzhanova, N. Hayashida et al. , "Thyroid function is associated with carotid intima-media thickness in euthyroid subjects, " Atherosclerosis, vol. 204, no. 2, pp. e77-e81, 2009.
37. R. P. F. Dullaart, R. de Vries, C. Roozendaal, A. C. M. Kobold, and W. J. Sluiter, "Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects, " Clinical Endocrinology, vol. 67, no. 5, pp. 668-673, 2007.
38. E. A. Palmieri, S. Fazio, G. Lombardi, and B. Biondi, "Subclinical hypothyroidism and cardiovascular risk: a reason to treat?" Treatments in Endocrinology, vol. 3, no. 4, pp. 233-244, 2004.
39. E. Pucci, L. Chiovato, and A. Pinchera, "Thyroid and lipid metabolism, " International Journal of Obesity, vol. 24, supplement 2, pp. S109-S112, 2000.
40. R. Arem, D. A. Escalante, N. Arem, J. D. Morrisett, and W. Patsch, "Effect of L-thyroxine therapy on lipoprotein fractions in overt and subclinical hypothyroidism, with special reference to lipoprotein(a), " Metabolism: Clinical and Experimental, vol. 44, no. 12, pp. 1559-1563, 1995.
41. V. Tsimihodimos, E. Bairaktari, C. Tzallas, G. Miltiadus, E. Liberopoulos, and M. Elisaf, "The incidence of thyroid function abnormalities in patients attending an outpatient lipid clinic, " Thyroid, vol. 9, no. 4, pp. 365-368, 1999.
42. S. Miura, M. Iitaka, H. Yoshimura et al. , "Disturbed lipid metabolism in patients with subclinical hypothyroidism: effect of L-thyroxine therapy, " InternalMedicine, vol. 33, no. 7, pp. 413-417, 1994.
43. M. Yildirimkaya, M. Ozata, K. Yilmaz, C. Kilinc, M. A. Gundogan, and T. Kutluay, "Lipoprotein(a) concentration in subclinical hypothyroidism before and after levo-thyroxine therapy, " Endocrine Journal, vol. 43, no. 6, pp. 731-736, 1996.
44. M. J. Nyirenda, D. N. Clark, A. R. Finlayson et al. , "Thyroid disease and increased cardiovascular risk, " Thyroid, vol. 15, no. 7, pp. 718-724, 2005.
45. J. A. Franklyn, J. Daykin, J. Betteridge et al. , "Thyroxine replacement therapy and circulating lipid concentrations, " Clinical Endocrinology, vol. 38, no. 5, pp. 453-459, 1993.
46. F. Monzani, N. Caraccio, M. Kozakowa et al. , "Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo-controlled stud, " Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 5, pp. 2099-2106, 2004.
47. A. W. C. Kung, R. W. C. Pang, I. Lauder, K. S. L. Lam, and E. D. Janus, "Changes in serum lipoprotein(a) and lipids during treatment of hyperthyroidism, " Clinical Chemistry, vol. 41, no. 2, pp. 226-231, 1995.
48. B. Muller, H. Zulewski, P. Huber, J. G. Ratcliffe, and J.-J. Stabu, "Impaired action of thyroid hormone associated with smoking in women with hypothyroidism, " The New England Journal of Medicine, vol. 333, no. 15, pp. 964-969, 1995.
49. Z. Efstathiadou, S. Bitsis, H. J. Milionis et al. , "Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?" European Journal of Endocrinology, vol. 145, no. 6, pp. 705-710, 2001.
50. A. W. C. Kung, R. W. C. Pang, and E. D. Janus, "Elevated serum lipoprotein(a) in subclinical hypothyroidism, " Clinical Endocrinology (Oxford), vol. 43, no. 4, pp. 445-449, 1995.
51. D. C. Bauer, B. Ettinger, and W. S. Browner, "Thyroid function and serum lipids in older women: a population-based study, " American Journal ofMedicine, vol. 104, no. 6, pp. 546-551, 1998.
52. M. J. M. Diekman, N. Anghelescu, E. Endert, O. Bakker, and W. M. Wiersinga, "Changes in plasma low-density lipoprotein (LDL)-and high-density lipoprotein cholesterol in hypo-and hyperthyroid patients are related to changes in free thyroxine, not to polymorphisms in LDL receptor or cholesterol ester transfer protein genes, " Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 5, pp. 1857-1862, 2000.
53. G. J. Canaris, N. R. Manowitz, G. Mayor, and E. C. Ridgway, "The colorado thyroid disease prevalence study, " Archives of Internal Medicine, vol. 160, no. 4, pp. 526-534, 2000.