Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: A reanalysis of intervention studies

Clinical Endocrinology

Volumn 44, Issue 6, 1996, Pages 643-649

  Tanis, Bea C ^a   Westendorp, Rudi G J ^a   Smelt, Augustinus H M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; THYROTROPIN; THYROXINE;

ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0029679711     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1996.739560.x     Document Type: Article

References (53)

1. Abrams, J.J. & Grundy, S.M. (1981) Cholesterol metabolism in hypothyroidism and hyperthyroidism in man. Journal of Lipid Research, 22, 323-338.
2. Angelin, B., Einarsson, K. & Leijd, B. (1983) Bile acid metabolism in hypothyroid subjects: response to substitution therapy. European Journal of Clinical Investigation, 13, 99-106.
3. Arem, R. & Patsch, W. (1990) Lipoprotein and apolipoprotein levels in subclinical hypothyroidism. Effect of levothyroxine therapy. Archives of Internal Medicine, 150, 2097-2100.
4. Aviram, M., Luboshitzky, R. & Brook, J.G. (1982) Lipid and lipoprotein pattern in thyroid dysfunction and the effect of therapy. Clinical Biochemistry, 1, 62-66.
5. Ball, M.J., Griffiths, D. & Thorogood, M. (1991) Asymptomatic hypothyroidism and hypercholesterolemia. Journal of the Royal Society of Medicine, 84, 527-529.
6. Bantle, J.P., Oppenheimer, J.H., Schwartz, H.L., Hunninghake, D.B., Probstfield, J.L. & Hanson, R.F. (1981) TSH response to TRH in euthyroid, hypereholesterolemic patients treated with graded dosis of dextrothyroxine. Metabolism, 30, 63-66.
7. Barbier, R., Paffoy, J.C., Venard-Sassolas, A. & Berthezene, F. (1980) Variations des taux plasmatiques de cholestérol porté par les lipoprotéines de haute densité au cours du traitement des dysthyroïdies. Diabete et Metabolisme, 6, 213-217.
8. Bell, G.M., Todd, W.T.A., Forfar, J.C., Martyn, C., Wathen, C.G., Gow, S., Riemersma, R. & Toft, A.D. (1985) End-organ responses to thyroxine therapy in subclinical hypothyroidism. Clinical Endocrinology, 22, 83-89.
9. Bloomer, H.A., Kyle, L.H. & Washington, D.C. (1959) Myxedema: a reevaluation of clinical diagnosis based on eighty cases. Archives of Internal Medicine, 104, 234-241.
10. Bogner, U., Arntz, H.R., Peters, H. & Schleusener, H. (1993) Subclinical hypothyroidism and hyperlipoproteinemia: indiscriminate L-thyroxine treatment not justified. Acta Endocrinology, 128, 202-206.
11. Caron, Ph., Calazel, C., Parra, H.J., Hoff, M. & Louvet, J.P. (1990) Decreased HDL cholesterol in subclinical hypothyroidism: the effect of L-thyroxine therapy. Clinical Endocrinology. 33, 519-523.
12. Cooper, D.S., Halpern, R., Wood, L.C., Levin, A.A. & Ridgway, E.C. (1984) L-Thyroxine in subclinical hypothyroidism. A double-blind, placebo controlled trial. Annals of Internal Medicine, 101, 18-24.
13. DerSimonian, R. & Laird, N. (1986) Meta-analysis in clinical trials. Controlled Clinical Trials, 7, 177-188.
14. Elder, J., McLelland, A., O'Reilly, D. St. J., Packard, C. J., Series, J.J. & Shepherd, J. (1990) The relationship between serum cholesterol and serum thyrotropin, thyroxine and tri-iodothyronine concentrations in suspected hypothyroidism. Annals of Clinical Biochemistry, 27, 110-113.
15. Fowler, P.B.S., Swale, J. & Andrews, H. (1970) Hypercholesterolaemia in borderline hypothyroidism, stage of premyxoedema. Lancet, ii, 488-491.
16. Franklyn, J.A. (1995) 'Subclinical hypothyroidism': to treat or not to treat, that is the question. Clinical Endocrinology, 43, 443-444.
17. Franklyn, J.A., Daykin, J., Betteridge, J., Hughes, E.A., Holder, R., Jones, S.R. & Sheppard, M.C. (1993) Thyroxine replacement therapy and circulating lipid concentrations. Clinical Endocrinology, 38, 453-459.
18. Friis, T. & Pedersen, L.R. (1987) Serum lipids in hyper- and hypothyroidism before and after treatment. Clinical Chimica Acta, 162, 115-163.
19. Geul, K.W., van Sluisveld, I.L.L., Grobbee, D.E. (1993) The importance of thyroid microsomal antibodies in the development of elevated serum TSH in middle-aged women: associations with serum lipids. Clinical Endocrinology, 39, 275-280.
20. Gorman, C.A., Jiang, N.S., Ellefson, R.D. & Elveback, L.R. (1979) Comparitive effectiveness of dextrothyroxin and levothyroxine in correcting hypothyroidism and lowering blood lipid levels in hypothyroid patients. Journal of Clinical Endocrinology and Metabolism, 49, 1-7.
21. Gray, R.S., Smith, A.F. & Clarke, B.F. (1981) Hypercholesterolemia in diabetics with clinically unrecognised primary thyroid failure. Hormone and Metabolic Research, 13, 508-510.
22. Green, W.L., Hazzard, W.R. & Hershman, J. (1976) Thyrotropin levels in hyperlipidemic survivors of myocardial infarction. Metabolism, 25, 465-470.
23. Greenland, S. (1987) Quantitative methods in the review of epidemiologic literature. American Journal of Epidemiology, Epidemiologic Reviews, 9, 1-30.
24. Johnston, J., McLelland, A. & O'Reilly, D. St. J. (1993) The relationship between serum cholesterol and serum thyroid hormones in male patients with suspected hypothyroidism. Annals of Clinical Biochemistry, 30, 256-259.
25. Kinlaw, W.B. (1991) Atherosclerosis and the thyroid. Thyroid today, 14, 1-8.
26. Kutty, K.M., Bryant, D.G. & Farid, N.R. (1978) Serum lipids in hypothyroidism, a reevaluation. Journal of Clinical Endocrinology and Metabolism, 46, 55-60.
27. Kuusi, T., Taskinen, M.R. & Nikkilä, E.A. (1988) Lipoproteins, lipolytic enzymes, and hormonal status in hypothyroid women at different levels of substitution. Journal of CLinical Endocrinology and Metabolism, 66, 51-56.
28. Law, M.R., Wald, N.J. & Thompson, S.G. (1994) By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischemic heart disease? British Medical Journal, 308, 367-373.
29. Leese, G.P., Jung, R.T., Guthrie, C., Waugh, N. & Browning, M.C.K. (1992) Morbidity in patients on L-thyroxine: a comparison of those with a normal TSH to these with a suppressed TSH. Clinical Endocrinology, 37, 500-503.
30. Lithell, H., Boberg, J., Hellsing, K., Ljunghall, S., Gudmar, L., Vessby, B. & Wide, L. (1981) Serum lipoprotein and apolipoprotein concentrations and tissue lipoprotein-lipase activity in overt and subclinical hypothyroidism: the effect of substitution therapy. European Journal of Clinical Investigation, 11, 3-10.
31. Mishkel, M.A. & Crowther, S.M. (1977) Hypothyroidism, an important cause of reversible hyperlipidemia. Clinical Chimica Acta, 74, 139-151.
32. Muls, E., Rosseneu, M., Blaton, V., Lesaffre, E., Lamberigts, G. & De Moor, P. (1984) Serum lipids and apolipoproteins A-I, A-II and B in primary hypothyroidism before and during treatment. European Journal of Clinical Investigation, 14, 12-15.
33. Nilsson, G., Nordlander, S. & Levin, K. (1976) Studies on subclinical hypothyroidism with special reference to the serum lipid pattern. Acta Medica Scandinavia, 200, 63-67.
34. Nordoy, A., Vik-Mo, H. & Berntsen, H. (1976) Haemostatic and lipid abnormalities in hypothyroidism. Scandinavion Journal of Haematology, 16, 154-160.
35. Nyström, E., Caidahl, K., Fager, G., Wikkelsö, C., Lundberg, P.A. & Lindstedt G. (1988) A double-blind cross-over 12-month study of L-thyroxine treatment of women with 'subclinical' hypothyroidism. Clinical Endocrinology, 29, 63-76.
36. O'Kane, M.J., Neely, R.D.G., Trimble, E.R. & Nicholls, D.P. (1991) The incidence of asymptomatic hypothyroidism in new referrals to a hospital lipid clinic. Annals of Clinical Biochemistry, 28, 509-511.
37. Okamura, K., Ueda, K., Sone, H., Ikenoue, H., Hasuo, Y., Sato, K., Yoshinari, M. & Fujishima, M. (1989) A sensitive thyroid stimulating hormone assay for screening of thyroid functional disorder in elderly Japanese. Journal of the American Geriatric Society, 37, 317-322.
38. Pallas, D., Koutras, D.A., Adamopoulos, P., Marafelia, P., Souvatzoglou, A., Pipiringos, G. & Moulopoulos, S.D. (1991) Increased mean serum thyrotropin in apparently euthyroid hypercholesterolemic patients: does it mean occult hypothyroidism? Journal of Endocrinological Investigation, 14, 743-746.
39. Parle, J.V., Franklyn, J.A., Cross, K.W., Jones, S.C. & Sheppard, M.C. (1991) Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clinical Endocrinology, 34, 77-83.
40. Ridgway, E.C., Cooper, D.S., Walker, H., Rodbard, D. & Maloof, F. (1981) Peripheral responses to thyroid hormone before and after L-thyroxine therapy in patients with subclinical hypothyroidism. Journal of Clinical Endocrinology and Metabolism, 53, 1238-1242.
41. Riniker, M., Tièche, M., Lupi, A., Grob, P., Studer, H. & Bürgi, H. (1981) Prevalence of various degrees of hypothyroidism among patients of a general medical department. Clinical Endocrinology, 14, 69-74.
42. Rosenthal, M.J., Hunt, W.C., Philip, J.G. & Goodwin, J.S. (1987) Thyroid failure in the elderly, microsomal antibodies as discriminant for therapy. JAMA, 258, 209-213.
43. Sawin, C.T., Castelli, W.P., Hershman, J.M., Mcnamara, P. & Bacharach, P. (1985) The aging thyroid. Thyroid deficiency in the Framingham Study. Archives of Internal Medicine, 145, 1386-1388.
44. Sawin, C.T., Geller, A., Wolf, P.A., Belanger, A.J., Baker, E., Bacharach, P., Wilson, P.W.F., Benjamin, E.J. & D'Agostino, R.B. (1994) Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. New England Journal of Medicine, 331, 1249-1252.
45. Series, J.J., Biggart, E.M., O'Reilly, D. St. J., Packard, C.J. & Shepherd, J. (1988) Thyroid dysfunction and hypercholesterolaemia in the general population of Glascow, Scotland. Clinica Chimica Acta, 172, 217-222.
46. Staub, J.J., Althaus, B.U., Engler, H., Ryff, A.S., Trabucco, P., Marquardt, K., Burckhardt, D., Girard, J. & Weintraub, B.D. (1992) Spectrum of subclinical and overt hypothyroidism: effect on thyrotropin, prolactin, and thyroid reserve, and metabolic impact on peripheral target tissues. American Journal of Medicine, 92, 631-642.
47. Toft, A.D. (1994) Thyroxine therapy. New England Journal of Medicine, 331, 174-180.
48. Turnbridge, W.M.G., Evered, D.C., Hall, R., Appleton, D., Brewis, M., Clark, F., Grimley Evans, J., Young, E., Bird, T. & Smith, P.A. (1977) The spectrum of thyroid disease in a community: the Wickham survey. Clinical Endocrinology, 7, 481-493.
49. Valdemarrson, S., Hansson, P., Hedner, P. & Nilsson-Ehle, P (1983) Relations between thyroid function, hepatic and lipoprotein lipase activities, and plasma lipoprotein concentrations. Acta Endocrinology, 104, 50-56.
50. Verdugo, C., Perrot, L., Ponsin, G., Valentin, C. & Berthezene, F. (1987) Time-course of alterations of high density lipoproteins (HDL) during thyroxine administration to hypothyroid women. European Journal of Clinical Investigation, 17, 313-316.
51. Wahlqvist, M.L., Fidge, N.H. & Lomas, F. (1977) Lipoprotein composition in hypothyroidism. Clinica Chimica Acta, 77, 269-274.
52. Wiersinga, W.M. (1995) Subclinical hypothyroidism and hyperthyroidism. I Prevalence and clinical relevance. Netherlands Journal of Medicine, 46, 197-204.
53. Wiseman, S.A., Powell, J.T., Humphries, S.E. & Press, M. (1993) The magnitude of the hypercholesterolemia of hypothyroidism is associated with variation in the low density lipoprotein receptor gene. Journal of Clinical Endocrinology and Metabolism, 77, 108-112.