ORMDL orosomucoid-like proteins are degraded by free-cholesterol-loading - Induced autophagy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 12, 2015, Pages 3728-3733

  Wang, Shuhui ^a   Robinet, Peggy ^a   Smith, Jonathan D ^a   Gulshan, Kailash ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Autophagy; Free cholesterol; ORMDL1; Serine palmitoyl coa transferase; Sphingomyelin

Indexed keywords

CHLOROQUINE; CHOLESTEROL; OROSOMUCOID; OROSOMUCOID LIKE PROTEIN 1; PROTEIN P62; SERINE PALMITOYLTRANSFERASE; SERINE PALMITOYLTRANSFERASE LONG CHAIN SUBUNIT 1; SERINE PALMITOYLTRANSFERASE LONG CHAIN SUBUNIT 2; SMALL INTERFERING RNA; SPHINGOLIPID; SPHINGOMYELIN; UNCLASSIFIED DRUG; CYCLOHEXIMIDE; LIPID; ORMDL1 PROTEIN, MOUSE;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIPID HOMEOSTASIS; LIPID STORAGE; LIPOGENESIS; MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STARVATION; UPREGULATION; ANIMAL; ASTHMA; ATHEROSCLEROSIS; CELL LINE; CELL MEMBRANE; CHEMISTRY; ENDOPLASMIC RETICULUM; EOSINOPHIL; HOMEOSTASIS; METABOLISM; MOUSE; PROTEIN TRANSPORT; TRANSPORT AT THE CELLULAR LEVEL;

EUKARYOTA;

ANIMALS; ASTHMA; ATHEROSCLEROSIS; AUTOPHAGY; BIOLOGICAL TRANSPORT; CELL LINE; CHOLESTEROL; CYCLOHEXIMIDE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EOSINOPHILS; HOMEOSTASIS; LIPIDS; MACROPHAGES; MEMBRANE MICRODOMAINS; MICE; OROSOMUCOID; PROTEIN TRANSPORT; SERINE C-PALMITOYLTRANSFERASE; SPHINGOLIPIDS; SPHINGOMYELINS;

EID: 84925397440     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1422455112     Document Type: Article

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