Modeling the contribution of individual proteins to mixed skeletal muscle protein synthetic rates over increasing periods of label incorporation

Journal of Applied Physiology

Volumn 118, Issue 6, 2015, Pages 655-661

  Miller, Benjamin F ^a   Wolff, Christopher A ^a   Peelor, Fredrick F ^a   Shipman, Patrick D ^a   Hamilton, Karyn L ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Deuterium oxide; Modeling; Protein synthesis; Stable isotope

Indexed keywords

DEUTERIUM OXIDE; MUSCLE PROTEIN;

ANIMAL; BIOSYNTHESIS; ISOTOPE LABELING; METABOLISM; MOUSE; MYOBLAST; PHYSIOLOGY; PROCEDURES; PROTEIN SYNTHESIS; SKELETAL MUSCLE; THEORETICAL MODEL;

ANIMALS; DEUTERIUM OXIDE; ISOTOPE LABELING; MICE; MODELS, THEORETICAL; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOBLASTS; PROTEIN BIOSYNTHESIS;

EID: 84925379750     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00987.2014     Document Type: Article

References (26)

1. Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. Science 319: 916-919, 2008.
2. Busch R, Kim YK, Neese RA, Schade-Serin V, Collins M, Awada M, Gardner JL, Beysen C, Marino ME, Misell LM, Hellerstein MK. Measurement of protein turnover rates by heavy water labeling of nonessential amino acids. Biochim Biophys Acta 1760: 730-744, 2006.
3. Drake JC, Bruns DR, Peelor FF, Biela LM, Miller RA, Hamilton KL, Miller BF. Long-lived crowded-litter mice have an age-dependent increase in protein synthesis to DNA synthesis ratio and mTORC1 substrate phosphorylation. Am J Physiol Endocrinol Metab 307: E813-E821, 2014.
4. Drake JC, Peelor FF, Biela LM, Watkins MK, Miller RA, Hamilton KL, Miller BF. Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic rapamycin feeding in male and female mice. J Gerontol A Biol Sci Med Sci 68: 1493-1501, 2013.
5. 2O to study the influence of feeding on protein synthesis: effect of isotope equilibration in vivo vs. in cell culture. Am J Physiol Endocrinol Metab 288: E1277-E1283, 2005.
6. Garlick PJ, McNurlan MA, Essén P, Wernerman J. Measurement of tissue protein synthesis rates in vivo: a critical analysis of contrasting methods. Am J Physiol Endocrinol Metab 266: E287-E297, 1994.
7. 2O to measure skeletal muscle protein synthesis. Nutr Metab (Lond) 7: 31, 2010.
8. Holm L, Reitelseder S, Dideriksen K, Nielsen RH, Bülow J, Kjaer M. The single-biopsy approach in determining protein synthesis in human slow-turning-over tissue: use of flood-primed, continuous infusion of amino acid tracers. Am J Physiol Endocrinol Metab 306: E1330-E1339, 2014.
9. Hwang H, Bowen BP, Lefort N, Flynn CR, De Filippis EA, Roberts C, Smoke CC, Meyer C, Højlund K, Yi Z, Mandarino LJ. Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes. Diabetes 59: 33-42, 2010.
10. Jahoor F, Zhang XJ, Baba H, Sakurai Y, Wolfe RR. Comparison of constant infusion and flooding dose techniques to measure muscle protein synthesis rate in dogs. J Nutr 122: 878-887, 1992.
11. Jaleel A, Short KR, Asmann YW, Klaus KA, Morse DM, Ford GC, Nair KS. In vivo measurement of synthesis rate of individual skeletal muscle mitochondrial proteins. Am J Physiol Endocrinol Metab 295: E1255-E1268, 2008.
12. Kasumov T, Dabkowski ER, Shekar KC, Li L, Ribeiro RF, Walsh K, Previs SF, Sadygov RG, Willard B, Stanley WC. Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria. Am J Physiol Heart Circ Physiol 304: H1201-H1214, 2013.
13. Lam MPY, Wang D, Lau E, Liem DA, Kim AK, Ng DCM, Liang X, Bleakley BJ, Liu C, Tabaraki JD, Cadeiras M, Wang Y, Deng MC, Ping P. Protein kinetic signatures of the remodeling heart following isoproterenol stimulation. J Clin Invest 124: 1734-1744, 2014.
14. Miller BF, Drake JC, Naylor B, Price JC, Hamilton KL. The measurement of protein synthesis for assessing proteostasis in studies of slowed aging. Ageing Res Rev 18: 106-111, 2014.
15. Miller BF, Hamilton KL. A perspective on the determination of mitochondrial biogenesis. Am J Physiol Endocrinol Metab 302: E496-E499, 2012.
16. Miller BF, Olesen JL, Hansen M, Døssing S, Crameri RM, Welling RJ, Langberg H, Flyvbjerg A, Kjaer M, Babraj JA, Smith K, Rennie MJ. Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise. J Physiol 567: 1021-1033, 2005.
17. Miller BF, Robinson MM, Bruss MD, Hellerstein M, Hamilton KL. A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction. Aging Cell 11: 150-161, 2012.
18. 2O labeling of the deoxyribose moiety of DNA. Proc Natl Acad Sci U S A 99: 15345-15350, 2002.
19. 2O and liquid chromatography tandem mass spectrometry. Anal Biochem 420: 73-83, 2012.
20. Rennie MJ, Smith K, Watt PW. Measurement of human tissue protein synthesis: an optimal approach. Am J Physiol Endocrinol Metab 266: E298-E307, 1994.
21. Robinson MM, Turner SM, Hellerstein MK, Hamilton KL, Miller BF. Long-term synthesis rates of skeletal muscle DNA and protein are higher during aerobic training in older humans than in sedentary young subjects but are not altered by protein supplementation. FASEB J 25: 3240-3249, 2011.
22. Rooyackers OE, Adey DB, Ades PA, Nair KS. Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc Natl Acad Sci U S A 93: 15364-15369, 1996.
23. Samarel AM. In vivo measurements of protein turnover during muscle growth and atrophy. FASEB J 5: 2020-2028, 1991.
24. Scalzo RL, Peltonen GL, Binns SE, Shankaran M, Giordano GR, Hartley DA, Klochak AL, Lonac MC, Paris HLR, Szallar SE, Wood LM, Peelor FF, Holmes WE, Hellerstein MK, Bell C, Hamilton KL, Miller BF. Greater muscle protein synthesis and mitochondrial biogenesis in males compared with females during sprint interval training. FASEB J 28: 2705-2714, 2014.
25. 2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans. Am J Physiol Endocrinol Metab 306: E571-E579, 2014.
26. Wilkinson SB, Phillips SM, Atherton PJ, Patel R, Yarasheski KE, Tarnopolsky MA, Rennie MJ. Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. J Physiol 586: 3701-3717, 2008.