Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action

ACS Chemical Biology

Volumn 10, Issue 3, 2015, Pages 834-843

  Artola, Marta ^a   Ruiz Avila, Laura B ^b   Vergonos, Albert ^b   Huecas, Sonia ^b   Araujo Bazán, Lidia ^b   Martin Fontecha, Mar ^a   Vázquez Villa, Henar ^a   Turrado, Carlos ^a   Ramirez Aportela, Erney ^b,c   Hoegl, Annabelle ^d   Nodwell, Matthew ^d   Barasoain, Isabel ^b   Chacon, Pablo ^c   Sieber, Stephan A ^d   Andreu, Jose M ^b   Lopez Rodriguez, Maria L ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BIPHENYL DERIVATIVE; FTSZ PROTEIN; FTSZ PROTEIN INHIBITOR; KANAMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN; BACTERIAL PROTEIN; CYTOSKELETON PROTEIN; FTSZ PROTEIN, BACTERIA; GUANOSINE TRIPHOSPHATE; NAPHTHALENE DERIVATIVE; PROTEIN BINDING;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL VIABILITY; BINDING SITE; CELL DIVISION; CONTROLLED STUDY; DRUG MECHANISM; GRAM POSITIVE BACTERIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; KINETICS; MICROBIAL SENSITIVITY TEST; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BACTERIA (MICROORGANISMS); POSIBACTERIA;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BINDING SITES; BIPHENYL COMPOUNDS; CYTOSKELETAL PROTEINS; GUANOSINE TRIPHOSPHATE; KINETICS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; NAPHTHALENES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925358851     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500974d     Document Type: Article

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