Alcohol and cancer: An overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1

Advances in Experimental Medicine and Biology

Volumn 815, Issue , 2015, Pages 59-70

  Seitz, Helmut K ^a   Mueller, Sebastian ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

4 Hydroxynonenal; Acetaldehyde; Clomethiazole; Cytochrome P450 2E1; DNA adducts; Epigenetics; Lipid peroxidation; Reactive oxygen species; Retinoic acid

Indexed keywords

ACETALDEHYDE; ALCOHOL; CARCINOGEN; CYTOCHROME P450 2E1; REACTIVE OXYGEN METABOLITE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; ISOENZYME; RETINAL DEHYDROGENASE;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ARTICLE; DISEASE SURVEILLANCE; DNA ADDUCT; DNA METHYLATION; DNA REPAIR; EPIGENETICS; EXPERIMENTAL STUDY; GENETIC CODE; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; LIPID PEROXIDATION; LIVER CARCINOGENESIS; MALIGNANT NEOPLASTIC DISEASE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; CHEMICALLY INDUCED; GENETICS; METABOLISM; NEOPLASM; NON-ALCOHOLIC FATTY LIVER DISEASE; PHYSIOLOGY; TOXICITY;

ACETALDEHYDE; ANIMALS; CYTOCHROME P-450 CYP2E1; ETHANOL; HUMANS; ISOENZYMES; NEOPLASMS; NON-ALCOHOLIC FATTY LIVER DISEASE; REACTIVE OXYGEN SPECIES; RETINAL DEHYDROGENASE;

EID: 84925321810     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-09614-8_4     Document Type: Article

References (49)

1. Lamu L (1910) Etude de statistique clinique de 131 cas de cancer de l'oesophage et due cardia. Arch Mal Appar Dig Mal Nutr 4:451-456
2. Baan R, Straif K, Grosse Y et al (2007) Carcinogenicity of alcoholic beverages. Lancet Oncol 8:292-293
3. Zakhari S, Vasiliou V, Max Guo Q (eds) (2011) Alcohol and cancer. Springer, New York
4. Beland FA, Benson RW, Mellick PW et al (2005) Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice. Food Chem Toxicol 43:1-19
5. Watabiki T, Okii Y, Tokiyasu T et al (2000) Long-term ethanol consumption in ICR mice causes mammary tumor in females and liver fibrosis in males. Alcohol Clin Exp Res 24:117S-122S
6. Roy HK, Gulizia JM, Karolski WJ et al (2002) Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasia. Cancer Epidemiol Biomarkers Prev 11:1499-1502
7. Soffritti M, Belpoggi F, Cevolani D et al (2002) Results of long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats. Ann N Y Acad Sci 982:46-69
8. Tsuchishima M, George J, Shiroeda H et al (2013) Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult. Dig Dis Sci 58:1923-1933
9. WHO (2010) IARC monographs on the evaluation of carcinogenic risks to humans, vol 96, Alcohol consumption and ethyl carbamate. IARC, France
10. Theruvathu JA, Jaruga P, Nath RG et al (2005) Polyamines stimulate the formation of mutagenic 1, N2-propanodeoxyguanosine adducts from acetaldehyde. Nucleic Acids Res 33:3513-3520
11. Seitz HK, Stickel F (2007) Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 7:599-612
12. Seitz HK, Stickel F (2006) Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem 387:349-360
13. Seitz HK, Mueller S (2013) Alcohol: metabolism, toxicity and its impact on nutrition. In: Dulbecco & Abelson (eds) Encyclopedia of Human Biology, 3rd Edition, Elsevier (in press)
14. Stickel F, Herold C, Seitz HK et al (2006) Alcohol and methyl transfer: Implications for alcohol related hepatocarcinogenesis. In: Ali S, Friedman SL, Mann DA (eds) Liver diseases: biochemical mechanisms and new therapeutic insights. Science, Enfield, pp 45-58
15. Kirpich I, Ghare S, Zhang J et al (2012) Binge alcohol-induced microvesicular liver steatosis and injury are associated with down regulation of hepatic Hdac 1, 7,9,10,11 and up regulation of Hdac 3. Alcohol Clin Exp Res 36:1578-1586
16. Seitz HK, Matsuzaki S, Yokoyama A et al (2001) Alcohol and cancer. Alcohol Clin Exp Res 25:137S-143S
17. Yokoyama A, Muramatsu T, Ohmori T et al (1998) Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 19:1383-1387
18. Bosron WF, Ehrig T, Li TK (1993) Genetic factors in alcohol metabolism and alcoholism. Semin Liver Dis 13:126-135
19. Yokoyama A, Tsutsumi E, Imazeki H et al (2007) Contribution of the alcohol dehydro-genase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. Int J Cancer 121:1047-1054
20. Lee CH, Lee JM, Wu DC et al (2008) Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. Int J Cancer 122:1347-1356
21. Yang SJ, Wang HY, Li XQ et al (2007) Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China. World J Gastroenterol 13:5760-5764
22. Seitz HK, Stickel F (2009) Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism. Genes Nutr 5:121-128
23. Harty LC, Caporaso NE, Hayes RB et al (1997) Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. J Natl Cancer Inst 89:1698-1705
24. Visapaa JP, Gotte K, Benesova M et al (2004) Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde. Gut 53:871-876
25. Homann N, Stickel F, Konig IR et al (2006) Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers. Int J Cancer 118:1998-2002
26. Homann N, Konig IR, Marks M et al (2009) Alcohol and colorectal cancer: the role of alcohol dehydrogenase 1C polymorphism. Alcohol Clin Exp Res 33:551-556
27. Coutelle C, Höhn B, Benesova M et al (2004) Risk factors in alcohol-associated breast cancer: alcohol dehydrogenase polymorphisms and estrogens. Int J Oncol 25:1127-1132
28. Homann N, Karkkainen P, Koivisto T et al (1997) Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa. J Natl Cancer Inst 89: 1692-1697
29. Simanowski UA, Suter P, Stickel F et al (1993) Esophageal epithelial hyperproliferation following long-term alcohol consumption in rats: effects of age and salivary gland function. J Natl Cancer Inst 85:2030-2033
30. Maier H, Weidauer H, Zoller J et al (1994) Effect of chronic alcohol consumption on the morphology of the oral mucosa. Alcohol Clin Exp Res 18:387-391
31. Oneta CM, Lieber CS, Li J et al (2002) Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase. J Hepatol 36:47-52
32. Seitz HK, Osswald B (1992) Effect of ethanol on procarcinogen activation. In: Watson R (ed) Alcohol and cancer. CRC, Boca Raton, pp 55-72
33. Lieber CS (1997) Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev 77:517-544
34. Liu C, Russell RM, Seitz HK et al (2001) Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1. Gastroenterology 120:179-189
35. Wang XD, Liu C, Chung J et al (1998) Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver. Hepatology 28:744-750
36. Wang XD, Seitz HK (2004) Alcohol and retinoid Interaction. In: Watson R (ed) Nutrition and alcohol: linking nutrient interactions and dietary intake. CRC, Boca Raton, pp 313-321
37. Dan Z, Popov Y, Patsenker E et al (2005) Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential. FASEB J 19:845-847
38. Bradford BU, Kono H, Isayama F, Kosyk O (2005) Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. Hepatology 41:336-344
39. Wang Y, Millonig G, Nair J et al (2009) Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. Hepatology 50:453-461
40. Millonig G, Wang Y, Homann N et al (2011) Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions. Int J Cancer 128:533-540
41. Lu Y, Zhuge J, Wang X et al (2008) Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 47:1483-1494
42. Chavez PR, Lian F, Chung J, Liu C, Paiva SA, Seitz HK et al (2011) Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats. J Nutr 141:1049-1055
43. Ye Q, Lian F, Chavez PR, Chung J, Ling W, Qin H et al (2012) Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. Hepatobiliary Surg Nutr 1:5-18
44. Weltman MD, Farrell GC, Hall P et al (1998) Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27:128-133
45. Dey A, Cederbaum AI (2007) Induction of cytochrome P450 2E1 promotes liver injury in ob/ ob mice. Hepatology 45:1355-1365
46. Wang Y, Seitz H, Wang X (2010) Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats. Alcohol Clin Exp Res 34:567-573
47. Ascha MS, Hanouneh IA, Lopez R, Tamimi TA, Feldstein AF, Zein NN (2010) The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 51:1972-1978
48. Liangpunsakul S, Chalasani N (2012) What should we recommend to our patients with NAFLD regarding alcohol use? Am J Gastroenterol 107:976-978
49. Seitz HK, Wang XD (2013) The role of cytochrome P450 2E1 in ethanol-mediated carcinogenesis. Subcell Biochem 67:131-143