Ox-LDL induces dysfunction of endothelial progenitor cells via activation of NF-κB

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Ji, Kang Ting ^a   Qian, Lu ^a   Nan, Jin Liang ^a   Xue, Yang Jing ^a   Zhang, Su Qin ^a   Wang, Guo Qiang ^a   Yin, Ri Peng ^a   Zhu, Yong Jin ^a   Wang, Lu Ping ^a   Ma, Jun ^a   Liao, Lian Ming ^b   Tang, Ji Fei ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN; LOW DENSITY LIPOPROTEIN;

ADHERENT CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; COLORIMETRY; ENDOTHELIAL PROGENITOR CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM CELL; FEMALE; FETUS BLOOD; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY;

CELLS, CULTURED; ENDOTHELIAL CELLS; FEMALE; FETAL BLOOD; HUMANS; LIPOPROTEINS, LDL; MESENCHYMAL STROMAL CELLS; NF-KAPPA B; OXIDATIVE STRESS;

EID: 84925310736     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/175291     Document Type: Article

References (43)

1. R. R. S. Packard and P. Libby, "Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction," Clinical Chemistry, vol. 54, no. 1, pp. 24-38, 2008.
2. P. J. Barnes and M. Karin, "Nuclear factor-κB-a pivotal transcription factor in chronic inflammatory diseases," The New England Journal of Medicine, vol. 336, no. 15, pp. 1066-1071, 1997.
3. S. S. Makarov, "NF-κb as a therapeutic target in chronic inflammation:Recent advances," Molecular Medicine Today, vol. 6, no. 11, pp. 441-448, 2000.
4. D. Tirziu, I. M. Jaba, P. Yu et al., "Endothelial nuclear factor- κB-dependent regulation of arteriogenesis and branching," Circulation, vol. 126, no. 22, pp. 2589-2600, 2012.
5. M. E. Davis, I. M. Grumbach, T. Fukai, A. Cutchins, and D. G. Harrison, "stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor κB binding," Journal of Biological Chemistry, vol. 279, no. 1, pp. 163-168, 2004.
6. S. Hoshi, M. Goto, N. Koyama, K.-I. Nomoto, and H. Tanaka, "Regulation of vascular smooth muscle cell proliferation by nuclear factor-κB and its inhibitor, I-κB," The Journal of Biological Chemistry, vol. 275, no. 2, pp. 883-889, 2000.
7. G. Rogler, K. Brand, D. Vogl et al., "Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa," Gastroenterology, vol. 115, no. 2, pp. 357-369, 1998.
8. B. M. Necela, W. Su, and E. A. Thompson, "Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor γ and nuclear factor-κB inmacrophages," Immunology, vol. 125, no. 3, pp. 344-358, 2008.
9. M. S. Penn and G. M. Chisolm, "Oxidized lipoproteins, altered cell function and atherosclerosis," Atherosclerosis, vol. 108, pp. S21-S29, 1994.
10. D. Steinberg and J. L. Witztum, "Lipoproteins and atherogenesis: current concepts," Journal of the American Medical Association, vol. 264, no. 23, pp. 3047-3052, 1990.
11. T. Kita, N. Kume, M. Yokode et al., "Oxidized-LDL and atherosclerosis role of LOX-1," Annals of the New York Academy of Sciences, vol. 902, pp. 95-102, 2000.
12. T. Kita, N. Kume, M. Minami et al., "Role of oxidized LDL in atherosclerosis," Annals of the New York Academy of Sciences, vol. 947, pp. 199-205, 2001.
13. M. Chen, T. Masaki, and T. Sawamura, "LOX-1, the receptor for oxidized low-density lipoprotein identified fromendothelial cells: implications in endothelial dysfunction and atherosclerosis," Pharmacology & Therapeutics, vol. 95, no. 1, pp. 89-100, 2002.
14. C. Meisinger, J. Baumert, N. Khuseyinova, H. Loewel, and W. Koenig, "Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population," Circulation, vol. 112, no. 5, pp. 651-657, 2005.
15. R. Hutter, F. E. Carrick, C. Valdiviezo et al., "Vascular endothelial growth factor regulates reendothelialization and neointima formation in a mouse model of arterial injury," Circulation, vol. 110, no. 16, pp. 2430-2435, 2004.
16. S. H. van Ierssel, P. G. Jorens, E. M. Van Craenenbroeck, and V. M. Conraads, "The endothelium, a protagonist in the pathophysiology of critical illness: focus on cellular markers," BioMed Research International, vol. 2014, Article ID 985813, 10 pages, 2014.
17. J. George, E. Goldstein, S. Abashidze et al., "Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation," European Heart Journal, vol. 25, no. 12, pp. 1003-1008, 2004.
18. Q. Xu, "Progenitor cells in vascular repair," Current Opinion in Lipidology, vol. 18, no. 5, pp. 534-539, 2007.
19. T. Imanishi, T. Hano, T. Sawamura, and I. Nishio, "Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction," Clinical and Experimental Pharmacology and Physiology, vol. 31, no. 7, pp. 407-413, 2004.
20. X. M. Feng, B. Zhou, Z. Chen et al., "Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase," Journal of Lipid Research, vol. 47, no. 6, pp. 1227-1237, 2006.
21. L. Liu, Z.-Z. Liu, H. Chen, G.-J. Zhang, Y.-H. Kong, and X.-X. Kang, "Oxidized low-density lipoprotein and β- glycerophosphate synergistically induce endothelial progenitor cell ossification," Acta Pharmacologica Sinica, vol. 32, no. 12, pp. 1491-1497, 2011.
22. Y. Wu, Q. Wang, L. Cheng, J. Wang, and G. Lu, "Effect of oxidized low-density lipoprotein on survival and function of endothelial progenitor cell mediated by p38 signal pathway," Journal of Cardiovascular Pharmacology, vol. 53, no. 2, pp. 151-156, 2009.
23. S. di Santo, N. Diehm, J. Ortmann et al., "Oxidized low density lipoprotein impairs endothelial progenitor cell function by downregulation of E-selectin and integrin αvβ5," Biochemical and Biophysical Research Communications, vol. 373, no. 4, pp. 528-532, 2008.
24. K. Ji, C. Xing, F. Jiang et al., "Benzo[a]pyrene induces oxidative stress and endothelial progenitor cell dysfunction via the activation of the NF-κB pathway," International Journal of Molecular Medicine, vol. 31, no. 4, pp. 922-930, 2013.
25. C.-P. Lin, F.-Y. Lin, P.-H. Huang et al., "Endothelial progenitor cell dysfunction in cardiovascular diseases: role of reactive oxygen species and inflammation," BioMed Research International, vol. 2013, Article ID 845037, 10 pages, 2013.
26. J. E. Deanfield, J. P. Halcox, and T. J. Rabelink, "Endothelial function and dysfunction: testing and clinical relevance," Circulation, vol. 115, no. 10, pp. 1285-1295, 2007.
27. F. Perticone, R. Ceravolo, A. Pujia et al., "Prognostic significance of endothelial dysfunction in hypertensive patients," Circulation, vol. 104, no. 2, pp. 191-196, 2001.
28. N. Werner, S. Kosiol, T. Schiegl et al., "Circulating endothelial progenitor cells and cardiovascular outcomes," The New England Journal of Medicine, vol. 353, no. 10, pp. 999-1007, 2005.
29. C. Schmidt-Lucke, L. Rössig, S. Fichtlscherer et al., "Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair," Circulation, vol. 111, no. 22, pp. 2981-2987, 2005.
30. T. Takahashi, C. Kalka, H. Masuda et al., "Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization," Nature Medicine, vol. 5, no. 4, pp. 434-438, 1999.
31. A. Aicher, M. Rentsch, K.-I. Sasaki et al., "Nonbone marrowderived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia," Circulation Research, vol. 100, no. 4, pp. 581-589, 2007.
32. J. Cheng, R. Cui, C. H. Chen, and J. Du, "Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells," Endocrinology, vol. 148, no. 5, pp. 2085-2094, 2007.
33. G. Tie, J. Yan, Y. Yang et al., "Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/akt pathway," Journal of Vascular Research, vol. 47, no. 6, pp. 519-530, 2010.
34. S. Hamed, B. Brenner, and A. Roguin, "Nitric oxide: a key factor behind the dysfunctionality of endothelial progenitor cells in diabetes mellitus type-2," Cardiovascular Research, vol. 91, no. 1, pp. 9-15, 2011.
35. G. Tie, K. E. Messina, J. Yan, J. A. Messina, and L. M. Messina, "Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells," Journal of the American Heart Association, vol. 3, no. 1, Article ID e000241, 2014.
36. 2 and antioxidants have opposite effects on activation of NF-xχB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor," The EMBO Journal, vol. 12, no. 5, pp. 2005-2015, 1993.
37. N. Li and M. Karin, "Is NF-κB the sensor of oxidative stress?" The FASEB Journal, vol. 13, no. 10, pp. 1137-1143, 1999.
38. J. Sugawara, M. Mitsui-Saito, C. Hayashi et al., "Decrease and senescence of endothelial progenitor cells in patients with preeclampsia," The Journal of Clinical Endocrinology & Metabolism, vol. 90, no. 9, pp. 5329-5332, 2005.
39. S. Verma, M. A. Kuliszewski, S.-H. Li et al., "C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease," Circulation, vol. 109, no. 17, pp. 2058-2067, 2004.
40. W. Suh, K. L. Kim, J.-H. Choi et al., "C-reactive protein impairs angiogenic functions and decreases the secretion of arteriogenic chemo-cytokines in human endothelial progenitor cells," Biochemical and Biophysical Research Communications, vol. 321, no. 1, pp. 65-71, 2004.
41. F. H. Seeger, J. Haendeler, D. H. Walter et al., "p38 mitogenactivated protein kinase downregulates endothelial progenitor cells," Circulation, vol. 111, no. 9, pp. 1184-1191, 2005.
42. Y.-H. Chen, S.-J. Lin, F.-Y. Lin et al., "High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms," Diabetes, vol. 56, no. 6, pp. 1559-1568, 2007.
43. N. Werner and G. Nickenig, "Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy?" Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 2, pp. 257-266, 2006.