Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.

Journal of the American Heart Association

Volumn 3, Issue 1, 2014, Pages

  Tie, Guodong ^a   Messina, Katharine E ^b   Yan, Jinglian ^b   Messina, Julia A ^b   Messina, Louis M ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; APOLIPOPROTEIN E; CDKN1A PROTEIN, MOUSE; CDKN1B PROTEIN, MOUSE; CDKN2A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2A; LOW DENSITY LIPOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NOTCH1 PROTEIN, MOUSE; NOTCH1 RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE;

AGING; ANIMAL; ARTICLE; C57BL MOUSE; CELL AGING; CELL CULTURE; CELL PROLIFERATION; DISEASE MODEL; DRUG EFFECT; GENETICS; HEMATOPOIETIC STEM CELL; HYPERCHOLESTEROLEMIA; KNOCKOUT MOUSE; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOLOGY; PHENOTYPE; TELOMERE SHORTENING; TIME;

AGEING; HEMATOPOIETIC STEM CELL; HYPERCHOLESTEROLEMIA; OXIDANT STRESS;

ANIMALS; ANTIOXIDANTS; APOLIPOPROTEINS E; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE MODELS, ANIMAL; HEMATOPOIETIC STEM CELLS; HYPERCHOLESTEROLEMIA; LIPOPROTEINS, LDL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; REACTIVE OXYGEN SPECIES; RECEPTOR, NOTCH1; TELOMERE SHORTENING; TIME FACTORS;

EID: 84898640122     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000241     Document Type: Article

References (0)