Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse

European Journal of Immunology

Volumn 44, Issue 10, 2014, Pages 3068-3080

  Khaznadar, Zena ^a,b   Henry, Guylaine ^c   Setterblad, Niclas ^d   Agaugue, Sophie ^a   Raffoux, Emmanuel ^b,c   Boissel, Nicolas ^b,c   Dombret, Hervé ^b,c   Toubert, Antoine ^a,b,c   Dulphy, Nicolas ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c SAINT LOUIS HOSPITAL   (France)

^d UNIVERSITÉ PARIS DIDEROT   (France)

Author keywords

Acute myeloid leukemia; Cancer immunity; Cytotoxicity; Immunological synapse; NK cell activating receptors

Indexed keywords

CYTOKINE; F ACTIN; LENALIDOMIDE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ACUTE GRANULOCYTIC LEUKEMIA; ADOPTIVE IMMUNOTHERAPY; ARTICLE; CELL INTERACTION; CELL SURFACE; CONJUGATION; CONTROLLED STUDY; DEGRANULATION; HL 60 CELL LINE; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; IN VITRO STUDY; LEUKEMIA CELL; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOMA CELL LINE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; TIME LAPSE IMAGING; CYTOTOXICITY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; IMMUNOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; HUMANS; IMMUNOLOGICAL SYNAPSES; KILLER CELLS, NATURAL; LEUKEMIA, MYELOID, ACUTE; MICROSCOPY, FLUORESCENCE; TIME-LAPSE IMAGING;

EID: 84925301577     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444500     Document Type: Article

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