Neonatal seizures: Dialogues between clinic and bench

Journal of the Formosan Medical Association

Volumn 111, Issue 5, 2012, Pages 239-244

  Huang, Li Tung ^a   Tain, You Lin ^a   Lai, Ming Chi ^b   Yang, San Nan ^c  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b Chi Mei Foundation Hospital   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Gamma aminobutyric acid; Neonatal seizure; Phenobarbital; Translation study

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ANTICONVULSIVE AGENT; BENZODIAZEPINE; BUMETANIDE; ETIRACETAM; GLUTAMATE RECEPTOR 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENOBARBITAL; PHENYTOIN; TOPIRAMATE; VALPROIC ACID;

ANTICONVULSANT ACTIVITY; ANTICONVULSANT THERAPY; BIRTH INJURY; BRAIN DEVELOPMENT; BRAIN MALFORMATION; COGNITIVE DEFECT; DISEASE PREDISPOSITION; DRUG SAFETY; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INBORN ERROR OF METABOLISM; INFANTILE SPASM; METABOLIC DISORDER; NEUROTOXICITY; NONHUMAN; PERINATAL INFECTION; PROTEIN EXPRESSION; REVIEW;

ANIMALS; ANTICONVULSANTS; BRAIN; HUMANS; INFANT, NEWBORN; PHENOBARBITAL; SEIZURES; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84861652935     PISSN: None     EISSN: 09296646     Source Type: Journal    
DOI: 10.1016/j.jfma.2011.12.007     Document Type: Review

References (46)

1. Volpe J.J. Neonatal seizures. Neurology of the newborn 2008, 203-244. WB Saunders, Philadelphia. 5th ed.
2. Ronen G.M., Penney S., Andrews W. The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study. J Pediatr 1999, 134:71-75.
3. Lanska M.J., Lanska D.J., Baumann R.J., Kryscio R.J. A population-based study of neonatal seizures in Fayette County, Kentucky. Neurology 1995, 45:724-732.
4. Saliba R.M., Annegers J.F., Waller D.K., Tyson J.E., Mizrahi E.M. Incidence of neonatal seizures in Harris County, Texas. Am J Epidemiol 1999, 150:763-769.
5. Scher M.S., Aso K., Beggarly M.E., Hamid M.Y., Steppe D.A., Painter M.J. Electrographic seizures in preterm and fullterm neonates: clinical correlates, associated brain lesions, and risk for neurologic sequelae. Pediatrics 1993, 91:128-134.
6. Tekgul H., Gauvreau K., Soul J., Murphy L., Robertson R., Stewart J., et al. The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics 2006, 117:1270-1280.
7. Painter M.J., Scher M.S., Stein A.D., Armatti S., Wang Z., Gardiner J.C., et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med 1999, 341:485-489.
8. Bartha A., Shen J., Katz K.H., Mischel R.E., Yap K.R., Ivacko J.A., et al. Neonatal seizures: multicenter variability in current treatment practices. Pediatr Neurol 2007, 37:85-90.
9. Khazipov R., Khalilov I., Tyzio R., Morozova E., Ben-Ari Y., Holmes G.L. Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. Eur J Neurosci 2004, 19:590-600.
10. Ben-Ari Y. Excitatory actions of GABA during development: the nature of the nurture. Nat Rev Neurosci 2002, 3:728-739.
11. Monyer H., Burnashev N., Laurie D.J., Sakmann B., Seeburg P.H. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 1994, 12:529-540.
12. Zhong J., Carrozz D.P., Williams K., Pritchett D.B., Molinoff P.B. Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain. J Neurochem 1995, 64:531-539.
13. Pellegrini-Giampietro D.E., Bennett M.V., Zukin R.S. Are Ca(2+)-permeable kainate/AMPA receptors more abundant in immature brain?. Neurosci Lett 1992, 144:65-69.
14. Johnston M.V. Developmental aspects of epileptogenesis. Epilepsia 1996, 37(Suppl. 1):S2-S9.
15. Holmes G.L., Ben-Ari Y. The neurobiology and consequences of epilepsy in the developing brain. Pediatr Res 2001, 49:320-325.
16. Lombroso C.T. Neonatal seizures: gaps between the laboratory and the clinic. Epilepsia 2007, 48(Suppl. 2):S83-106.
17. Miller P., Weiss B.S., Barnwell A., Ferriero D.M., Latal-Hajnal B., Ferrer-Rogers A., et al. Seizure-associated brain injury in term newborns with perinatal asphyxia. Neurology 2002, 58:542-548.
18. Ronen G.M., Buckley D., Penney S., Streiner D.L. Long-term prognosis in children with neonatal seizures: a population-based study. Neurology 2007, 69:1816-1822.
19. Cilio M.R., Sogawa Y., Cha B.H., Liu X., Huang L.T., Holmes G.L. Long-term effects of status epilepticus in the immature brain are specific for age and model. Epilepsia 2003, 44:518-528.
20. Rizzi M., Perego C., Aliprandi M., Richichi C., Ravizza T., Colella D., et al. Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development. Neurobiol Dis 2003, 14:494-503.
21. Huang L.T., Holmes G.L., Lai M.C., Hung P.L., Wang C.L., Wang T.J., et al. Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures. Epilepsia 2002, 43:1141-1148.
22. Huang L.T., Cilio M.R., Silveira D.C., McCabe B.K., Sogawa Y., Stafstrom C.E., et al. Long-term effects of neonatal seizures: a behavioral, electrophysiological, and histological study. Dev Brain Res 1999, 118:99-107.
23. Cornejo B.J., Mesches M.H., Coultrap S., Browning M.D., Benke T.A. A single episode of neonatal seizures permanently alters glutamatergic synapses. Ann Neurol 2007, 61:411-426.
24. Zhang G., Raol Y.H., Hsu F.C., Coulter D.A., Brooks-Kayal A.R. Effects of status epilepticus on hippocampal GABAA receptors are age-dependent. Neuroscience 2004, 125:299-303.
25. McCabe B.K., Silveira D.C., Cilio M.R., Cha B.H., Liu X., Sogawa Y., et al. Reduced neurogenesis after neonatal seizures. J Neurosci 2001, 21:2094-2103.
26. Holmes G.L., Gairsa J.L., Chevassus-Au-Louis N., Ben-Ari Y. Consequences of neonatal seizures in the rat: morphological and behavioral effects. Ann Neurol 1998, 44:845-857.
27. Karnam H.B., Zhou J.L., Huang L.T., Zhao Q., Shatskikh T., Holmes G.L. Early life seizures cause long-standing impairment of the hippocampal map. Exp Neurol 2009, 217:378-387.
28. Huang L.T., Yang S.N., Liou C.W., Hung P.L., Lai M.C., Wang C.L., et al. Pentylenetetrazol-induced recurrent seizures in rat pups: time course on spatial learning and long-term effects. Epilepsia 2002, 43:567-573.
29. Farwell J.R., Lee Y.J., Hirtz D.G., Sulzbacher S.I., Ellenberg J.H., Nelson K. Phenobarbital for febrile seizures-effects on intelligence and on seizure recurrence. N Engl J Med 1990, 322:364-369.
30. Diaz J., Schain R.J. Phenobarbital: effects of long-term administration on behavior and brain of artificially reared rats. Science 1978, 199:90-91.
31. Bittigau P., Sifringer M., Genz K., Reith E., Pospischil D., Govindarajalu S., et al. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci USA 2002, 99:15089-15094.
32. Kim J., Kondratyev A., Gale K. Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy. J Pharmacol Exp Ther 2007, 323:165-173.
33. Glier C., Dzietko M., Bittigau P., Jarosz B., Korobowicz E., Ikonomidou C. Therapeutic doses of topiramate are not toxic to the developing rat brain. Exp Neurol 2004, 187:403-409.
34. Manthey D., Asimiadou S., Stefovska V., Kaindl A.M., Fassbender J., Ikonomidou C., et al. Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain. Exp Neurol 2005, 193:497-503.
35. Rogawski M.A., Loscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci 2004, 5:553-564.
36. Shoemaker M.T., Rotenberg J.S. Levetiracetam for the treatment of neonatal seizures. J Child Neurol 2007, 22:95-98.
37. Hmaimess G., Kadhim H., Nassogne M.C., Bonnier C., van Rijckevorsel K. Levetiracetam in a neonate with malignant migrating partial seizures. Pediatr Neurol 2006, 34:55-59.
38. Piña-Garza J.E., Nordli D.R., Rating D., Yang H., Schiemann-Delgado J., Duncan B., et al. Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures. Epilepsia 2009, 50:1141-1149.
39. Ben-Ari Y., Holmes G.L. Effects of seizures on developmental process in the immature brain. Lancet Neurol 2006, 5:1055-1063.
40. Isaev D., Isaeva E., Khazipov R., Holmes G.L. Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus. Hippocampus 2007, 17:210-219.
41. Khalilov I., Le Van Quyen M., Gozlan H., Ben-Ari Y. Epileptogenic actions of GABA and fast oscillations in the developing hippocampus. Neuron 2005, 48:787-796.
42. Ben-Ari Y., Khazipov R., Leinekugel X., Caillard O., Gaiarsa J.L. GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage à trois'. Trends Neurosci 1997, 20:523-529.
43. Koh S., Jensen F.E. Topiramate blocks perinatal hypoxia-induced seizures in rat pups. Ann Neurol 2001, 50:366-372.
44. Liu Y., Barks J.D., Xu G., Silverstein F.S. Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats. Stroke 2004, 35:1460-1465.
45. Dzhala V.I., Talos D.M., Sdrulla D.A., Brumback A.C., Mathews G.C., Benke T.A., et al. NKCC1 transporter facilitates seizures in the developing brain. Nat Neurosci 2005, 11:1205-1213.
46. Silverstein F.S., Ferriero D.M. Off-label use of antiepileptic drugs for the treatment of neonatal seizures. Pediatr Neurol 2008, 39:77-79.