Conformational Difference in Human IgG2 Disulfide Isoforms Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

Biochemistry

Volumn 54, Issue 10, 2015, Pages 1956-1962

  Zhang, Aming ^a,b   Fang, Jing ^a,c   Chou, Robert Y T ^a   Bondarenko, Pavel V ^a   Zhang, Zhongqi ^a  

^a AMGEN INC   (United States)

^b GLAXOSMITHKLINE   (United States)

^c WATERS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBODIES; CELL MEMBRANES; COVALENT BONDS; EPITOPES; HYDROGEN; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; SOLVENTS; SPECTROMETRY;

AMINO ACID RESIDUES; CONFORMATIONAL DIFFERENCES; DISULFIDE LINKAGES; GLOBAL STRUCTURE; HYDROGEN/DEUTERIUM EXCHANGE; SPATIAL PROXIMITY; STRUCTURAL DIFFERENCES; STRUCTURAL MODELS;

SULFUR COMPOUNDS;

AMINO ACID; DISULFIDE; EPITOPE; FATTY ACID BINDING PROTEIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; SOLVENT; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY LABELING; ANTIGEN BINDING; ARTICLE; CELL SURFACE; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; DISULFIDE BOND; HEAVY CHAIN; HUMAN; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN UNFOLDING; REVERSED PHASE LIQUID CHROMATOGRAPHY; CHEMISTRY; PROCEDURES; PROTEIN QUATERNARY STRUCTURE;

ANTIBODIES, MONOCLONAL; DEUTERIUM EXCHANGE MEASUREMENT; DISULFIDES; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MASS SPECTROMETRY; PROTEIN STRUCTURE, QUATERNARY;

EID: 84925258872     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5015216     Document Type: Article

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