Gestational lead exposure induces developmental abnormalities and up-regulates apoptosis of fetal cerebellar cells in rats

Drug and Chemical Toxicology

Volumn 38, Issue 1, 2015, Pages 73-83

  Mousa, Alyaa M ^a   Al Fadhli, Ameera S ^a   Rao, Muddanna S ^a   Kilarkaje, Narayana ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Caspase 3; developmental neuropathology; embryotoxicity; heavy metals; p53; pro apototic proteins; teratogenesis

Indexed keywords

CASPASE 3; LEAD NITRATE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; BAX PROTEIN, RAT; LEAD; NITRIC ACID DERIVATIVE; POLLUTANT;

ABDOMINAL WALL DEFECT; ANALYZER; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN TOXICITY; CAUSE OF DEATH; CELL GRANULE; CEREBELLUM CELL; CEREBELLUM CORTEX; CESAREAN SECTION; CONTROLLED STUDY; CYTOTOXICITY; DEVELOPMENTAL DISORDER; EAR MALFORMATION; EMBRYO; ENVIRONMENTAL EXPOSURE; EXPOSURE; EYE MALFORMATION; FEMALE; FETUS; FETUS MORTALITY; GESTATIONAL AGE; GROWTH RETARDATION; IMMUNOHISTOCHEMISTRY; LEAD POISONING; LIMB MALFORMATION; MALE; NECK MALFORMATION; NISSL SUBSTANCE; NONHUMAN; PURKINJE CELL; RAT; UPREGULATION; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CONGENITAL ABNORMALITIES; DRUG EFFECTS; EMBRYOLOGY; METABOLISM; ORGANOGENESIS; PATHOLOGY; POLLUTANT; PREGNANCY; SPRAGUE DAWLEY RAT; TOXICITY; WISTAR RAT;

EPICOCCUM; RATTUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CEREBELLAR CORTEX; CONGENITAL ABNORMALITIES; ENVIRONMENTAL POLLUTANTS; FEMALE; IMMUNOHISTOCHEMISTRY; LEAD; MATERNAL EXPOSURE; NITRATES; ORGANOGENESIS; PREGNANCY; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84925242027     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480545.2014.907578     Document Type: Article

References (47)

1. Atlante A, Bobba A, Paventi G, et al. (2010). Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells. Biochem Pharmacol 79:758-767.
2. Audesirk T, Audesirk G, Ferguson C, Shugarts D. (1991). Effects of inorganic lead on the differentiation and growth of cultured hippocampal and neuroblastoma cells. Neurotoxicology 13:529-538.
3. Baranowska-Bosiacka I, Gutowska I, Marchetti C, et al. (2011). Altered energy status of primary cerebellar granule neuronal cultures from rats exposed to lead in the pre- and neonatal period. Toxicology 280: 24-32.
4. Baranowska-Bosiacka I, Gutowska I, Rybicka M, et al. (2012). Neurotoxicity of lead. Hypothetical molecular mechanisms of synaptic function disorders. Neurol Neurochir Pol 46:569-578.
5. Borja-Aburto VH, Bermúdez-Castro O, Lacasaña-Navarro M, et al. (1999). Difficulties of the methods for studying environmental exposure and neural tube defects. Salud Publica Mex 41:S124-S131.
6. Cecil KM, Brubaker CJ, Adler CM, et al. (2008). Decreased brain volume in adults with childhood lead exposure. PLoS Med 5:e112.
7. Chang BJ, Jang BJ, Son TG, et al. (2012). Ascorbic acid ameliorates oxidative damage induced by maternal low-level lead exposure in the hippocampus of rat pups during gestation and lactation. Food Chem Toxicol 50:104-108.
8. Devi CB, Reddy GH, Prasanthi RP, et al. (2005). Developmental lead exposure alters mitochondrial monoamine oxidase and synaptosomal catecholamine levels in rat brain. Int J Dev Neurosci 23: 375-381.
9. Dribben WH, Creeley CE, Farber N. (2011). Low-level lead exposure triggers neuronal apoptosis in the developing mouse brain. Neurotoxicol Teratol 33:473-480.
10. Elmore S. (2007). Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495-516.
11. Gardella C. (2001). Lead exposure in pregnancy: a review of the literature and argument for routine prenatal screening. Obstet Gynecol Surv 56:231-238.
12. Gargouri M, Ghorbel-Koubaa F, Bonenfant-Magné M, et al. (2012). Spirulina or dandelion-enriched diet of mothers alleviates leadinduced damages in brain and cerebellum of newborn rats. Food Chem Toxicol 50:2303-2310.
13. Gilbert ME, Kelly ME, Samsam TE, Goodman JH. (2005). Chronic developmental lead exposure reduces neurogenesis in adult rat hippocampus but does not impair spatial learning. Toxicol Sci 86: 365-374.
14. Green DR, Reed JC. (1998). Mitochondria and apoptosis. Science 281: 1309-1312.
15. Han S, Pfizenmaier DH, Garcia E, et al. (2000). Effects of lead exposure before pregnancy and dietary calcium during pregnancy on fetal development and lead accumulation. Environ Health Perspect 108: 527-531.
16. He L, Poblenz AT, Medrano CJ, Fox DA. (2000). Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. J Biol Chem 275: 12175-12184.
17. Heng YH, Barry G, Richards LJ, Piper M. (2012). Nuclear factor 1 genes regulate neuronal migration. Neurosignals 20:159-167.
18. Iriyama T, Kamei Y, Kozuma S, Taketani Y. (2009). Bax-inhibiting peptide protects glutamate-induced cerebellar granule cell death by blocking Bax translocation. Neurosci Lett 451:11-15.
19. Jelliffe-Pawlowski LL, Miles SQ, Courtney JG, et al. (2006). Effect of magnitude and timing of maternal pregnancy blood lead (Pb) levels on birth outcomes. J Perinatol 26:154-162.
20. Jin Y, Yu F, Liao Y, et al. (2011). Therapeutic efficiency of succimer used with calcium and ascorbic acid in the treatment of mild leadpoisoning. Environ Toxicol Pharmacol 31:137-142.
21. Kern M, Audesirk T, Audesirk G. (1993). Effects of inorganic lead on the differentiation and growth of cortical neurons in culture. Neurotoxicology 14:319-327.
22. Kiran Kumar B, Prabhakara Rao Y, Noble T, et al. (2009). Lead-induced alteration of apoptotic proteins in different regions of adult rat brain. Toxicol Lett 184:56-60.
23. Lidsky TI, Schneider JS. (2003). Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126:5-19.
24. Liu J, Ai Y, McCauley L, et al. (2012). Blood lead levels and associated sociodemographic factors among preschool children in the South Eastern region of China. Paediatr Perinat Epidemiol 26:61-69.
25. Liu J, Han D, Li Y, et al. (2010). Lead affects apoptosis and related gene XIAP and Smac expression in the hippocampus of developing rats. Neurochem Res 35:473-479.
26. Marchetti C. (2003). Molecular targets of lead in brain neurotoxicity. Neurotox Res 5:221-236.
27. Müller YM, Rivero LB, Carvalho MC, et al. (2008). Behavioral impairments related to lead-induced developmental neurotoxicity in chicks. Arch Toxicol 82:445-451.
28. Mycyk M, Hryhorczuk D, Amitai Y. (2005). Lead. In: Erickson TB, Ahrens WR, Aks SE, et al., eds. Pediatric toxicology: diagnosis and management of the poisoned child, 1st ed. New York: McGraw-Hill Professional, 461-467.
29. Narayana K, Al-Bader M. (2011). Ultrastructural and DNA damaging effects of lead nitrate in the liver. Exp Toxicol Pathol 63: 43-51.
30. Norman DJ, Feng L, Cheng SS, et al. (1995). The lurcher gene induces apoptotic death in cerebellar Purkinje cells. Development 121: 1183-1193.
31. Oberto A, Marks N, Evans HL, Guidotti A. (1996). Lead (Pb+2) promotes apoptosis in newborn rat cerebellar neurons: pathological implications. J Pharmacol Exp Ther 279:435-442.
32. Patrick GW, Anderson WJ. (2000). Dendritic alterations of cerebellar Purkinje neurons in postnatally lead-exposed kittens. Dev Neurosci 22:320-328.
33. Pearson HA, Schonfeld DJ. (2003). Lead. In: Rudolph CD, ed. Rudolph's pediatrics, 21st ed. New York: McGraw-Hill Professional, 1016-1056.
34. Prasanthi RP, Devi CB, Basha DC, et al. (2010). Calcium and zinc supplementation protects lead (Pb)-induced perturbations in antioxidant enzymes and lipid peroxidation in developing mouse brain. Int J Dev Neurosci 28:161-167.
35. Ramos-Vara JA. (2005). Technical aspects of immunohistochemistry. Vet Pathol 42:405-426.
36. Reddy GR, Basha MR, Devi CB, et al. (2003). Lead induced effects on acetylcholinesterase activity in cerebellum and hippocampus of developing rat. Int J Dev Neurosci 21:347-352.
37. Sannadi S, Kadeyala PK, Gottipolu RR. (2013). Reversal effect of monoisoamyl dimercaptosuccinic acid (MiADMSA) for arsenic and lead induced perturbations in apoptosis and antioxidant enzymes in developing rat brain. Int J Dev Neurosci 31:586-597.
38. Scortegagna M, Hanbauer I. (1997). The effect of lead exposure and serum deprivation on mesencephalic primary cultures. Neurotoxicology 18:331-339.
39. Shi LZ, Zheng W. (2007). Early lead exposure increases the leakage of the blood-cerebrospinal fluid barrier, in vitro. Hum Exp Toxicol 26: 159-167.
40. Simonati A, Tosati C, Rosso T, et al. (1999). Cell proliferation and death: morphological evidence during corticogenesis in the developing human brain. Microsc Res Tech 45:341-352.
41. Stein J, Schettler T, Wallinga D, Valenti M. (2002). In harm's way: toxic threats to child development. J Dev Behav Pediatr 23:S13-S22.
42. Toscano CD, Guilarte TR. (2005). Lead neurotoxicity: from exposure to molecular effects. Brain Res Brain Res Rev 49:529-554.
43. Várnagy L, Budai P, Molnár E, et al. (2000). Interaction of Dithane M-45 (mancozeb) and lead acetate during a teratogenicity test in rats. Acta Vet Hung 48:113-124.
44. Velaga MK, Basuri CK, Robinson Taylor KS, et al. (2013). Ameliorative effects of Bacopa monniera on lead-induced oxidative stress in different regions of rat brain. Drug Chem Toxicol. [Epub ahead of print]. doi: 10.3109/01480545.2013.866137.
45. Wilson MA, Johnston MV, Goldstein GW, Blue ME. (2000). Neonatal lead exposure impairs development of rodent barrel field cortex. Proc Natl Acad Sci USA 97:5540-5545.
46. Xu J, Ji LD, Xu LH. (2006). Lead-induced apoptosis in PC 12 cells: involvement of p53, Bcl-2 family and caspase-3. Toxicol Lett 166: 160-167.
47. Zhang W, Ghetti B, Lee WH. (1997). Decreased IGF-I gene expression during the apoptosis of Purkinje cells in pcd mice. Brain Res Dev Brain Res 98:164-176.