Ascorbic acid ameliorates oxidative damage induced by maternal low-level lead exposure in the hippocampus of rat pups during gestation and lactation

Food and Chemical Toxicology

Volumn 50, Issue 2, 2012, Pages 104-108

  Chang, Byung Joon ^a   Jang, Bong Jun ^b   Son, Tae Gen ^c   Cho, Ik Hyun ^d   Quan, Fu Shi ^e   Choe, Nong Hoon ^a   Nahm, Sang Soep ^a   Lee, Jong Hwan ^a  

^a Konkuk University   (South Korea)

^b Hanyang University   (South Korea)

^c Dongnam Institute of Radiological and Medical Science   (South Korea)

^d Kyung Hee University   (South Korea)

^e JILIN UNIVERSITY   (China)

Author keywords

Ascorbic acid; Catalase; Developing brain; Lead toxicity; Superoxide dismutase

Indexed keywords

ASCORBIC ACID; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; LEAD; MANGANESE SUPEROXIDE DISMUTASE; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN DAMAGE; BRAIN TISSUE; CELL COUNT; CELL DAMAGE; CONTROLLED STUDY; DENTATE GYRUS; DRUG EFFECT; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; HISTOPATHOLOGY; LACTATION; LEAD POISONING; NONHUMAN; OXIDATIVE STRESS; PREGNANCY; PRENATAL EXPOSURE; RAT; SUCKLING; VITAMIN SUPPLEMENTATION; WESTERN BLOTTING;

ANIMALS; ASCORBIC ACID; BODY WEIGHT; CATALASE; ENVIRONMENTAL POLLUTANTS; FEMALE; HIPPOCAMPUS; LACTATION; LEAD; MATERNAL EXPOSURE; NEURONS; OXIDATIVE STRESS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

RATTUS;

EID: 84855279853     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.09.043     Document Type: Article

References (42)

1. Acharya U.R., Rathore R.M., Mishra M. Role of vitamin C on lead acetate induced spermatogenesis in swiss mice. Environ. Toxicol. Pharmacol. 2003, 13:9-14.
2. Adonaylo V.N., Oteiza P.I. Lead intoxication: antioxidant defenses and oxidative damage in rat brain. Toxicology 1999, 135:77-85.
3. Ahamed M., Siddiqui M.K.J. Low level lead exposure and oxidative stress current opinions. Clin. Chim. Acta 2007, 383:57-64.
4. Alfano D.P., Petit T.L. Behavioral effects of postnatal Pb exposure: possible relationship to hippocampal dysfunction. Behav. Neural Boil. 1981, 32:319-333.
5. Altmann L., Weinsberg F., Sveinsson K., Lilienthal H., Wiegand H., Winneke G. Impairment of long-term potentiation and learning following chronic lead exposure. Toxicol. Lett. 1993, 66:105-111.
6. Bennet C., Bettaiya R., Rajanna S., Baker L., Yallapragada P.R., Brice J.J., White S.L., Bokara K.K. Region specific increase in the antioxidant enzymes and lipid peroxidation products in the brain of rats exposed to lead. Free Radic. Res 2007, 41(3):267-273.
7. Bokara K.K., Blaylock I., Denise S.B., Bettaiya R., Rajanna S., Yallapragada P.R. Influence of lead acetate on glutathione and its related enzymes in different regions of rat brain. J. Appl. Toxicol. 2009, 29:452-458.
8. Bressler J., Kim K.A., Chakraborti T., Goldstein G. Mechanism of lead neurotoxicity. Neurochem. Res. 1999, 24:595-600.
9. Burdette L.J., Goldstein R. Long-term behavioral and electrophysiological changes associated with lead exposure at different stages of brain development in the rat. Dev. Brain Res. 1986, 29:101-110.
10. Campbell J.B., Woolley D.E., Vijayan V.K., Overmann S.R. Morphometric effects of postnatal lead exposure on hippocampal development of the 15-day-old rat. Dev. Brain Res. 1982, 3:595-612.
11. Chaurasia S.S., Kar A. Protective effects of vitamin E against lead-induced deterioration of membrane associated type-I iodothyronine 5'-monodeiodinase (5'D-I) activity in male mice. Toxicology 1997, 124:203-209.
12. Ercal N., Treratphan P., Hammond T.C., Mathews R.H., Grannemann N.H., Spitz D.R. In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetyl cysteine. Free Radic. Biol. Med. 1996, 21:157-161.
13. Flora S.J.S., Tandon S.K. Prevention and therapeutic effects of thiamin, ascorbic acid and their combination in Pb intoxication. Acta Pharmacol. Toxicol. 1986, 58:374-378.
14. Frei B. On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc. Soc. Exp. Biol. Med. 1999, 222:196-204.
15. Fridovich I. Superoxide dismutases. Advances in Enzymology 1974, 35-97. John Wiley, New York, (vol. 41). A. Meister (Ed.).
16. Garza A., Vega R., Soto E. Cellular mechanisms of lead neurotoxicity. Med. Sci. Monit. 2006, 12:57-65.
17. Grundman M., Delaney P. Antioxidant strategies for Alzheimer's disease. Proc. Nutr. Soc. 2002, 61:191-202.
18. Guaiquil V.H., Vera J.C., Golde D.W. Mechanism of vitamin C inhibition of cell death induced by oxidative stress in glutathione-depleted HL-60 cell. J. Biol. Chem. 2001, 276:40955-40961.
19. Gürer H., özgünes H., Neal R., Spitz D.R., Erçal N. Antioxidant effects of N-acetyl cysteine and succimer in red blood cells from lead-exposed rats. Toxicology 1998, 128:181-189.
20. Han J.M., Chang B.J., Li T.Z., Choe N.H., Quan F.S., Jang B.J., Cho I.H., Hong H.N., Lee J.H. Protective effects of ascorbic acid against lead-induced apoptotic neurodegeneration in the developing rat hippocampus in vivo. Brain Res. 2007, 185:68-74.
21. Hsu P.C., Liu M.Y., Hsu C.C., Chen L.Y., Guo Y.L. Effects of vitamin E and/or C on reactive oxygen species related lead toxicity in the rat sperm. Toxicology 1998, 128:169-179.
22. Hsu P.C., Guo Y.L. Antioxidant nutrients and lead toxicity. Toxicology 2002, 180:33-44.
23. Hu Q., Fu H., Ren T., Wang S., Zhou W., Song H., Han Y., Dong S. Maternal low-level lead exposure reduces the expression of PSA-NCAM and the activity of sialyltransferase in the hippocampi of neonatal rat pups. Neurotoxicology 2008, 29:675-681.
24. Lau A.T., Wang Y., Chiu J.F. Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. J. Cell. Biochem. 2008, 104(2):657-667.
25. Lockitch G. Perspectives on lead toxicity. Clin. Biochem. 1993, 26:371-381.
26. Lutsenko E.A., Carcamom J.M., Goldem D.W. Vitamin C prevents DNA mutation induced by oxidative stress. J. Biol. Chem. 2002, 277:16895-16899.
27. Massó-González E.L., Antonio-García M.T. Natural antioxidants protect against lead-induced damage during pregnancy and lactation in rat's pups. Ecotoxicol. Environ. Saf. 2009, 72:2137-2142.
28. Mates J.M., Perez-Gomez C., Nunez de Castro I. Antioxidant enzymes and human diseases. Clin. Biochem. 1999, 32:595-603.
29. Moreira E.G., Vassilieff I., Vassilieff V.S. Developmental lead exposure: behavioral alterations in the short and long term. Neurotoxicol. Teratol. 2001, 23:489-495.
30. Patra R.C., Swarup D., Dwivedi S.K. Antioxidant effects of α tocopherol, ascorbic acid and l-methionine on Pb induced oxidative stress to the liver, kidney and brain in rats. Toxicology 2001, 162:81-88.
31. Rice M.E. Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci. 2000, 23:209-216.
32. Sandhir R., Julka D., Gill K.D. Lipoperoxidative damage on lead exposure in rat brain and its implications on membrane bound enzymes. Pharmacol. Toxicol. 1994, 74:66-71.
33. Sidhu R.S., Tuor U.L., Del Bigio M.R. Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occur more frequently in immature than older rats. Neurosci. Lett. 1997, 223:129-132.
34. Siushansian R., Wilson J.X. Ascorbate transport and intracellular concentration in cerebral astrocytes. J. Neurochem. 1995, 65:41-49.
35. Soltaninejad K., Kebriaeezadeh A., Minaiee B., Ostad S.N., Hosseini R., Azizi E., Abdollahi M. Biochemical and ultrastructural evidences for toxicity of lead through free radicals in rat brain. Hum. Exp. Toxicol. 2003, 22:417-423.
36. Stohs S.J., Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 1995, 18:321-336.
37. Valenzuela A., Lefauconnier J.M., Chaudiere J., Bourre J.M. Effects of lead acetate on cerebral glutathione peroxidase and catalase in the suckling rat. Neurotoxicology 1989, 10(1):63-69.
38. Vaziri N.D., Lin C., Farmand F., Sindhu R.K. Superoxide dismutase, catalase, glutathione, peroxidase and NADPH oxidase in lead-induced hypertension. Kidney Int. 2003, 63:186-194.
39. Vij A.G., Satija N.K., Flora S.J. Lead induced disorders in hematopoietic and drug metabolizing enzyme system and their protection by ascorbic acid supplementation. Biomed. Environ. Sci. 1998, 11:7-14.
40. West W.L., Knight E.M., Edwards C.H., Manning M., Spurlock B., James H., Johnson A.A. Maternal low level lead and pregnancy outcomes. J. Nutr. 1994, 124:981-986.
41. Wilson J.X., Peters C.E., Sitar S.M., Daoust P., Gelb A.W. Glutamate stimulates ascorbate transport by astrocytes. Brain Res. 2000, 858:61-66.
42. Yin S.T., Tang M.L., Su L., Chen L., Hu P., Wang H.L., Wang M., Ruan D.Y. Effects of epigallocatechin-3-gallate on lead-induced oxidative damage. Toxicology 2008, 249:45-54.