Lead induced effects on acetylcholinesterase activity in cerebellum and hippocampus of developing rat

International Journal of Developmental Neuroscience

Volumn 21, Issue 6, 2003, Pages 347-352

  Reddy, Gottipuolu R ^a   Basha, Md Riyaz ^b   Devi, C Bhuvaneswari ^c   Suresh, Ambati ^a   Baker, John L ^a   Shafeek, Abdul ^c   Heinz, Josephine ^a   Chetty, Chellu S ^a  

^a SAVANNAH STATE UNIVERSITY   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c SRI VENKATESWARA UNIVERSITY   (India)

Author keywords

Acetylcholinesterase; Cerebellum; Hippocampus; Lead

Indexed keywords

ACETYLCHOLINESTERASE; LEAD; LEAD ACETATE; PHYSOSTIGMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN REGION; CEREBELLUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENTATE GYRUS; ENZYME ACTIVITY; FEMALE; GRANULE CELL; HIPPOCAMPUS; HISTOCHEMISTRY; IN VITRO STUDY; MALE; NEWBORN; NONHUMAN; PERINATAL PERIOD; POSTNATAL DEVELOPMENT; PREGNANCY; PRIORITY JOURNAL; RAT;

EID: 0041621460     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-5748(03)00071-6     Document Type: Article

References (24)

1. Alfano D.P., Petit T.L., LeBoutillier J.C. Development and plasticity of the hippocampal-cholinergic system in normal and early lead exposed rats. Brain Res. 312:1983;117-124.
2. Basha M.R., Wei W., Brydie M., Razmiafshari M., Zawia N.H. Lead-induced developmental perturbations in hippocampal Sp1 DNA-binding are prevented by zinc supplementation: in vivo evidence for Pb and Zn competition. Int. J. Dev. Neurosci. 21:2003;1-12.
3. Bourjeily N., Suszkiw J.B. Developmental cholinotoxicity of lead: loss of septal cholinergic neurons and long-term changes in cholinergic innervation of the hippocampus in perinatally lead-exposed rats. Brain Res. 771:1997;319-328.
4. Bressler J.P., Goldstein G.W. Mechanisms of lead neurotoxicity. Biochem. Pharmacol. 41:1991;479-484.
5. Carroll P.T., Silbergeld E.K., Goldberg A.M. Alteration of central cholinergic function by chronic lead acetate exposure. Biochem. Pharmacol. 26:1977;397-402.
6. Chetty C.S., Reddy G.R., Murthy K.S., Johnson J., Sajwan K., Desaiah D. Perinatal lead exposure alters the expression of neuronal nitric oxide synthase in rat brain. Int. J. Toxicol. 20:2001;113-120.
7. Cory-Slechta D.A., Pokora M.J., Widzowski D.V. Postnatal lead exposure induces super sensitivity to the stimulus properties of a D2-D3 agonist. Brain Res. 598:1992;162-172.
8. Davis J.M., Otto D.A., Weil D.E., Grant L.E. The comparative developmental neurotoxicity of lead in humans and animals. Neurotoxicol. Teratol. 12:1990;215-317.
9. Ellman G.L., Courtney K.D., Andres V., Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:1961;88-95.
10. Gietzen D.W., Woolley D.E. Acetylcholinesterase activity in the brain of rat pups and dams after exposure to lead via maternal water supply. NeuroToxicology. 5:1984;235-246.
11. Hedreen J.C., Bacon S.J., Price D.L. A modified histochemical technique to visualize acetylcholinesterase containing axons. J. Histochem. Cytochem. 33:1985;134-140.
12. Karnovsky M.J., Roots L. A direct coloring thiocholine method for cholinesterase. J. Histochem. Cytochem. 12:1964;219-225.
13. Kuhlmann A.C., McGlothan J.L., Guilarte T.R. Developmental lead exposure causes spatial learning deficits in adult rats. Neurosci. Lett. 233:1977;101-114.
14. Modak A.T., Stavinoha W.B. Cholinergic system of mice during hypokinesis caused by chronic lead ingestion. Neurobehav. Toxicol. 1:1980;107-111.
15. Modak A.T., Weintraub S.T., Stavinoha W.B. Effect of chronic ingestion of lead on the central cholinergic system in rat brain regions. Toxicol. Appl. Pharmacol. 34:1975;340-347.
16. Needleman H.L., Schell A., Bellinger D., Leviton A., Allred E.N. The long-term effects of exposure to low doses of lead in childhood: an 11 year follow-up. New Eng. J. Med. 322:1990;83-88.
17. Reddy G.R., Zawia N.H. Lead exposure alters Egr-1 DNA-binding in the neonatal rat brain. Int. J. Dev. Neurosci. 18:2000;791-795.
18. Reddy G.R., Suresh A., Murthy K.S., Chetty C.S. Lead neurotoxicity: heme oxygenase and nitric oxide synthase activities in developing rat brain. Neurotox. Res. 4:2002;33-39.
19. Rodrigues A.L.S., Rocha J.B.T., Mello C.F., Souza D.O. Effect of perinatal lead exposure on rat behavior in open-field and two-way avoidance tasks. Pharmacol. Toxicol. 79:1996;150-156.
20. Shih T.M., Hanin I. Effects of chronic lead exposure on levels of acetylcholine and choline and on acetylcholine turnover rate in rat brain areas in vivo. Psychopharmacology (Berl.). 58:1978;263-269.
21. Silbergeld E.K., Goldberg A.M. Pharmacological and neurochemical investigations of lead-induced hyperactivity. Neuropharmacology. 14:1975;431-444.
22. Sun X., Tian X., Suszkiw J.B. Reduction of choline acetyltransferase mRNA in the septum of developing rat exposed to inorganic lead. NeuroToxicology. 18:1997;201-207.
23. Tomlinson G., Mutus B., McLennan I. Activation and inactivation of acetylcholinesterase by metal ions. Can. J. Biochem. 59:1981;728-735.
24. Zawia N.H., Sharan R., Brydie M., Uyama T., Crumpton T. SP1 as a target site for metal-induced perturbations of transcriptional regulation of developmental brain gene expression. Dev. Brain Res. 107:1998;291-298.