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Volumn 111, Issue 11, 2014, Pages 2200-2208

Enhancing fatty acid ethyl ester production in Saccharomyces cerevisiae through metabolic engineering and medium optimization

Author keywords

Biodiesel; Fatty acid ethyl ester; Metabolic engineering; Nitrogen limitation; Saccharomyces cerevisiae

Indexed keywords

BIOCHEMISTRY; BIODIESEL; ESTERIFICATION; ESTERS; METABOLIC ENGINEERING; METABOLISM; SUBSTRATES; YEAST;

EID: 84925235492     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25292     Document Type: Article
Times cited : (40)

References (37)
  • 1
    • 84871904714 scopus 로고    scopus 로고
    • Identification of a residue affecting fatty alcohol selectivity in wax ester synthase
    • Barney BM, Mann RL, Ohlert JM. 2013. Identification of a residue affecting fatty alcohol selectivity in wax ester synthase. Appl Environ Microbiol 79(1):396-399.
    • (2013) Appl Environ Microbiol , vol.79 , Issue.1 , pp. 396-399
    • Barney, B.M.1    Mann, R.L.2    Ohlert, J.M.3
  • 2
    • 84866174695 scopus 로고    scopus 로고
    • Differences in substrate specificities of five bacterial wax ester synthases
    • Barney BM, Wahlen BD, Garner E, Wei J, Seefeldt LC. 2012. Differences in substrate specificities of five bacterial wax ester synthases. Appl Environ Microbiol 78(16):5734-5745.
    • (2012) Appl Environ Microbiol , vol.78 , Issue.16 , pp. 5734-5745
    • Barney, B.M.1    Wahlen, B.D.2    Garner, E.3    Wei, J.4    Seefeldt, L.C.5
  • 3
    • 33947316606 scopus 로고    scopus 로고
    • Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation
    • Black PN, DiRusso CC. 2007. Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation. Biochim Biophys Acta 1771(3):286-298.
    • (2007) Biochim Biophys Acta , vol.1771 , Issue.3 , pp. 286-298
    • Black, P.N.1    DiRusso, C.C.2
  • 4
    • 84866744379 scopus 로고    scopus 로고
    • Controlling promoter strength and regulation in Saccharomyces cerevisiae using synthetic hybrid promoters
    • Blazeck J, Garg R, Reed B, Alper HS. 2012. Controlling promoter strength and regulation in Saccharomyces cerevisiae using synthetic hybrid promoters. Biotechnol Bioeng 109(11):2884-2895.
    • (2012) Biotechnol Bioeng , vol.109 , Issue.11 , pp. 2884-2895
    • Blazeck, J.1    Garg, R.2    Reed, B.3    Alper, H.S.4
  • 5
    • 0021668558 scopus 로고
    • A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance
    • Boeke J, Croute F, Fink G. 1984. A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol Gen Genet 197(2):345-346.
    • (1984) Mol Gen Genet , vol.197 , Issue.2 , pp. 345-346
    • Boeke, J.1    Croute, F.2    Fink, G.3
  • 6
    • 0026442388 scopus 로고
    • Coordinated regulation and inositol-mediated and fatty acid-mediated repression of fatty acid synthase genes in Saccharomyces cerevisiae
    • Chirala SS. 1992. Coordinated regulation and inositol-mediated and fatty acid-mediated repression of fatty acid synthase genes in Saccharomyces cerevisiae. Proc Natl Acad Sci 89(21):10232-10236.
    • (1992) Proc Natl Acad Sci , vol.89 , Issue.21 , pp. 10232-10236
    • Chirala, S.S.1
  • 7
    • 84879015951 scopus 로고    scopus 로고
    • Synthesis of medium chain length fatty acid ethyl esters in engineered Escherichia coli using endogenously produced medium chain fatty acids
    • Fan L, Liu J, Nie K, Liu L, Wang F, Tan T, Deng L. 2013. Synthesis of medium chain length fatty acid ethyl esters in engineered Escherichia coli using endogenously produced medium chain fatty acids. Enzyme Microb Technol 53(2):128-133.
    • (2013) Enzyme Microb Technol , vol.53 , Issue.2 , pp. 128-133
    • Fan, L.1    Liu, J.2    Nie, K.3    Liu, L.4    Wang, F.5    Tan, T.6    Deng, L.7
  • 9
    • 35048864748 scopus 로고    scopus 로고
    • Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae
    • Feddersen S, Neergaard TBF, Knudsen J, Faergeman NJ. 2007. Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae. Biochem J 407:219-230.
    • (2007) Biochem J , vol.407 , pp. 219-230
    • Feddersen, S.1    Neergaard, T.B.F.2    Knudsen, J.3    Faergeman, N.J.4
  • 10
    • 0035663815 scopus 로고    scopus 로고
    • Biodiesel fuel production by transesterification of oils
    • Fukuda H, Kondo A, Noda H. 2001. Biodiesel fuel production by transesterification of oils. J Biosci Bioeng 92(5):405-416.
    • (2001) J Biosci Bioeng , vol.92 , Issue.5 , pp. 405-416
    • Fukuda, H.1    Kondo, A.2    Noda, H.3
  • 12
    • 80052919515 scopus 로고    scopus 로고
    • Delete and repeat: A comprehensive toolkit for sequential gene knockout in the budding yeast Saccharomyces cerevisiae
    • Hegemann J, Heick S. 2011. Delete and repeat: A comprehensive toolkit for sequential gene knockout in the budding yeast Saccharomyces cerevisiae. Methods Mol Biol 765:189-206. doi: 10.1007/978-1-61779-197-0_12
    • (2011) Methods Mol Biol , vol.765 , pp. 189-206
    • Hegemann, J.1    Heick, S.2
  • 14
    • 84894351695 scopus 로고    scopus 로고
    • Production of triacylglycerols in Escherichia coli by deletion of the diacylglycerol kinase gene and heterologous overexpression of atfA from Acinetobacter baylyi ADP1
    • Janßen H, Steinbüchel A. 2014. Production of triacylglycerols in Escherichia coli by deletion of the diacylglycerol kinase gene and heterologous overexpression of atfA from Acinetobacter baylyi ADP1. Appl Microbiol Biotechnol 98(4):1913-1924.
    • (2014) Appl Microbiol Biotechnol , vol.98 , Issue.4 , pp. 1913-1924
    • Janßen, H.1    Steinbüchel, A.2
  • 15
    • 10444228204 scopus 로고    scopus 로고
    • Synthesis of novel lipids in Saccharomyces cerevisiae by heterologous expression of an unspecific bacterial acyltransferase
    • Kalscheuer R, Luftmann H, Steinbuchel A. 2004. Synthesis of novel lipids in Saccharomyces cerevisiae by heterologous expression of an unspecific bacterial acyltransferase. Appl Environ Microbiol 70(12):7119-7125.
    • (2004) Appl Environ Microbiol , vol.70 , Issue.12 , pp. 7119-7125
    • Kalscheuer, R.1    Luftmann, H.2    Steinbuchel, A.3
  • 16
    • 33748762752 scopus 로고    scopus 로고
    • Microdiesel: Escherichia coli engineered for fuel production
    • Kalscheuer R, Stolting T, Steinbuchel A. 2006. Microdiesel: Escherichia coli engineered for fuel production. Microbiology 152:2529-2536.
    • (2006) Microbiology , vol.152 , pp. 2529-2536
    • Kalscheuer, R.1    Stolting, T.2    Steinbuchel, A.3
  • 17
    • 33846700140 scopus 로고    scopus 로고
    • Engineered microorganisms for sustainable production of diesel fuel and other oleochemicals from renewable plant biomass
    • Kalscheuer R, Stoveken T, Steinbuchel A. 2007. Engineered microorganisms for sustainable production of diesel fuel and other oleochemicals from renewable plant biomass. Intern Sugar J 109(1297):16-19.
    • (2007) Intern Sugar J , vol.109 , Issue.1297 , pp. 16-19
    • Kalscheuer, R.1    Stoveken, T.2    Steinbuchel, A.3
  • 18
    • 36348956692 scopus 로고    scopus 로고
    • DGA1 (diacylglycerol acyltransferase gene) overexpression and leucine biosynthesis significantly increase lipid accumulation in the Δsnf2 disruptant of Saccharomyces cerevisiae
    • Kamisaka Y, Tomita N, Kimura K, Kainou K, Uemura H. 2007. DGA1 (diacylglycerol acyltransferase gene) overexpression and leucine biosynthesis significantly increase lipid accumulation in the Δsnf2 disruptant of Saccharomyces cerevisiae. Biochem J 408(1):61-68.
    • (2007) Biochem J , vol.408 , Issue.1 , pp. 61-68
    • Kamisaka, Y.1    Tomita, N.2    Kimura, K.3    Kainou, K.4    Uemura, H.5
  • 19
    • 77957219602 scopus 로고
    • High efficiency transformation of Saccharomyces cerevisiae by electroporation
    • Manivasakam P, Schiestl RH. 1993. High efficiency transformation of Saccharomyces cerevisiae by electroporation. Nucleic Acids Res 21(18):4414-4415.
    • (1993) Nucleic Acids Res , vol.21 , Issue.18 , pp. 4414-4415
    • Manivasakam, P.1    Schiestl, R.H.2
  • 20
    • 0028953840 scopus 로고
    • Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds
    • Mumberg D, Müller R, Funk M. 1995. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156(1):119-122.
    • (1995) Gene , vol.156 , Issue.1 , pp. 119-122
    • Mumberg, D.1    Müller, R.2    Funk, M.3
  • 21
    • 76849088375 scopus 로고    scopus 로고
    • Fatty acid alkyl esters: Perspectives for production of alternative biofuels
    • Röttig A, Wenning L, Bröker D, Steinbüchel A. 2010. Fatty acid alkyl esters: Perspectives for production of alternative biofuels. Appl Microbiol Biotechnol 85(6):1713-1733.
    • (2010) Appl Microbiol Biotechnol , vol.85 , Issue.6 , pp. 1713-1733
    • Röttig, A.1    Wenning, L.2    Bröker, D.3    Steinbüchel, A.4
  • 22
    • 84891829362 scopus 로고    scopus 로고
    • Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived biofuels and chemicals
    • Runguphan W, Keasling JD. 2014. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived biofuels and chemicals. Metab Eng 21:103-113.
    • (2014) Metab Eng , vol.21 , pp. 103-113
    • Runguphan, W.1    Keasling, J.D.2
  • 23
    • 33645236555 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity
    • Saerens SMG, Verstrepen KJ, Van Laere SDM, Voet ARD, Van Dijck P, Delvaux FR, Thevelein JM. 2006. The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. J Biol Chem 281(7):4446-4456.
    • (2006) J Biol Chem , vol.281 , Issue.7 , pp. 4446-4456
    • Saerens, S.M.G.1    Verstrepen, K.J.2    Van Laere, S.D.M.3    Voet, A.R.D.4    Van Dijck, P.5    Delvaux, F.R.6    Thevelein, J.M.7
  • 24
    • 0029787239 scopus 로고    scopus 로고
    • Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae
    • Schjerling CK, Hummel R, Hansen JK, Børsting C, Mikkelsen JM, Kristiansen K, Knudsen J. 1996. Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae. J Biol Chem 271(37):22514-22521.
    • (1996) J Biol Chem , vol.271 , Issue.37 , pp. 22514-22521
    • Schjerling, C.K.1    Hummel, R.2    Hansen, J.K.3    Børsting, C.4    Mikkelsen, J.M.5    Kristiansen, K.6    Knudsen, J.7
  • 25
    • 84857243863 scopus 로고    scopus 로고
    • Functional expression and characterization of five wax ester synthases in Saccharomyces cerevisiae and their utility for biodiesel production
    • Shi S, Valle-Rodriguez JO, Khoomrung S, Siewers V, Nielsen J. 2012. Functional expression and characterization of five wax ester synthases in Saccharomyces cerevisiae and their utility for biodiesel production. Biotechnol Biofuels 5:7.
    • (2012) Biotechnol Biofuels , vol.5 , pp. 7
    • Shi, S.1    Valle-Rodriguez, J.O.2    Khoomrung, S.3    Siewers, V.4    Nielsen, J.5
  • 27
    • 14544268951 scopus 로고    scopus 로고
    • The wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase from Acinetobacter sp. strain AD P1: Characterization of a novel type of acyltransferase
    • Stoveken T, Kalscheuer R, Malkus U, Reichelt R, Steinbuchel A. 2005. The wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase from Acinetobacter sp. strain AD P1: Characterization of a novel type of acyltransferase. J Bacteriol 187(4):1369-1376.
    • (2005) J Bacteriol , vol.187 , Issue.4 , pp. 1369-1376
    • Stoveken, T.1    Kalscheuer, R.2    Malkus, U.3    Reichelt, R.4    Steinbuchel, A.5
  • 29
    • 45749137679 scopus 로고    scopus 로고
    • Minimal Escherichia coli cell for the most efficient production of ethanol from hexoses and pentoses
    • Trinh CT, Unrean P, Srienc F. 2008. Minimal Escherichia coli cell for the most efficient production of ethanol from hexoses and pentoses. Appl Environ Microbiol 74:3634-3643.
    • (2008) Appl Environ Microbiol , vol.74 , pp. 3634-3643
    • Trinh, C.T.1    Unrean, P.2    Srienc, F.3
  • 30
    • 0034933704 scopus 로고    scopus 로고
    • The genetics of fatty acid metabolism in Saccharomyces cerevisiae
    • Trotter PJ. 2001. The genetics of fatty acid metabolism in Saccharomyces cerevisiae. Annu Rev Nutr 21(1):97-119.
    • (2001) Annu Rev Nutr , vol.21 , Issue.1 , pp. 97-119
    • Trotter, P.J.1
  • 31
    • 70349436024 scopus 로고    scopus 로고
    • Functional assembly of minicellulosomes on the Saccharomyces cerevisiae cell surface for cellulose hydrolysis and ethanol production
    • Tsai S-L, Oh J, Singh S, Chen R, Chen W. 2009. Functional assembly of minicellulosomes on the Saccharomyces cerevisiae cell surface for cellulose hydrolysis and ethanol production. Appl Environ Microbiol 75(19):6087-6093.
    • (2009) Appl Environ Microbiol , vol.75 , Issue.19 , pp. 6087-6093
    • Tsai, S.-L.1    Oh, J.2    Singh, S.3    Chen, R.4    Chen, W.5
  • 32
    • 84888393717 scopus 로고    scopus 로고
    • Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid ethyl esters, an advanced biofuel, by eliminating non-essential fatty acid utilization pathways
    • Valle-Rodríguez JO, Shi S, Siewers V, Nielsen J. 2014. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid ethyl esters, an advanced biofuel, by eliminating non-essential fatty acid utilization pathways. Appl Energy 115:226-232.
    • (2014) Appl Energy , vol.115 , pp. 226-232
    • Valle-Rodríguez, J.O.1    Shi, S.2    Siewers, V.3    Nielsen, J.4
  • 34
    • 84893013220 scopus 로고    scopus 로고
    • Use of limited proteolysis and mutagenesis to identify folding domains and sequence motifs critical for wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase activity
    • Villa JA, Cabezas M, de la Cruz F, Moncalián G. 2014. Use of limited proteolysis and mutagenesis to identify folding domains and sequence motifs critical for wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase activity. Appl Environ Microbiol 80:1132-1141.
    • (2014) Appl Environ Microbiol , vol.80 , pp. 1132-1141
    • Villa, J.A.1    Cabezas, M.2    de la Cruz, F.3    Moncalián, G.4
  • 35
    • 79957980223 scopus 로고    scopus 로고
    • Industrial fermentation of renewable diesel fuels
    • Westfall PJ, Gardner TS. 2011. Industrial fermentation of renewable diesel fuels. Curr Opin Biotechnol 22(3):344-350.
    • (2011) Curr Opin Biotechnol , vol.22 , Issue.3 , pp. 344-350
    • Westfall, P.J.1    Gardner, T.S.2
  • 36
    • 81455143861 scopus 로고    scopus 로고
    • Synthesis of FAEEs from glycerol in engineered Saccharomyces cerevisiae using endogenously produced ethanol by heterologous expression of an unspecific bacterial acyltransferase
    • Yu KO, Jung J, Kim SW, Park CH, Han SO. 2012. Synthesis of FAEEs from glycerol in engineered Saccharomyces cerevisiae using endogenously produced ethanol by heterologous expression of an unspecific bacterial acyltransferase. Biotechnol Bioeng 109(1):110-115.
    • (2012) Biotechnol Bioeng , vol.109 , Issue.1 , pp. 110-115
    • Yu, K.O.1    Jung, J.2    Kim, S.W.3    Park, C.H.4    Han, S.O.5
  • 37
    • 84859633048 scopus 로고    scopus 로고
    • Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids
    • Zhang F, Carothers JM, Keasling JD. 2012. Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids. Nat Biotech 30(4):354-359.
    • (2012) Nat Biotech , vol.30 , Issue.4 , pp. 354-359
    • Zhang, F.1    Carothers, J.M.2    Keasling, J.D.3


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