High adipose LPL activity and adipocyte hypertrophy reduce visceral fat and metabolic risk in obese, older women

Obesity

Volumn 23, Issue 3, 2015, Pages 602-607

  Serra, Monica C ^a,b   Ryan, Alice S ^a,b   Sorkin, John D ^a,b   Favor, Knachelle H ^a,b   Goldberg, Andrew P ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEIN LIPASE; TRIACYLGLYCEROL; LPL PROTEIN, HUMAN;

ABDOMINAL FAT; ABDOMINAL FAT ASPIRATION BIOPSY; ADIPOCYTE HYPERTROPHY; ADIPOSE TISSUE; ADULT; AGE DISTRIBUTION; ARTICLE; BODY COMPOSITION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME ACTIVITY; ENZYME ANALYSIS; FAT CELL WEIGHT; FEMALE; GLUTEAL FAT; HUMAN; HUMAN TISSUE; HYPERTROPHY; INTRAABDOMINAL FAT; LIPID STORAGE; MAJOR CLINICAL STUDY; METABOLIC DISORDER; METABOLIC PARAMETERS; METABOLIC RISK; OBESITY; POSTMENOPAUSE; PREVALENCE; RISK; RISK REDUCTION; SUBCUTANEOUS FAT; ADIPOCYTE; BODY WEIGHT; CASE CONTROL STUDY; COMPLICATION; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; PATHOLOGY; RISK FACTOR;

ABDOMINAL FAT; ADIPOCYTES; ADIPOSITY; BODY COMPOSITION; BODY WEIGHT; CASE-CONTROL STUDIES; FEMALE; HUMANS; HYPERTROPHY; INTRA-ABDOMINAL FAT; LIPOPROTEIN LIPASE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; POSTMENOPAUSE; RISK FACTORS; SUBCUTANEOUS FAT;

EID: 84925235228     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20998     Document Type: Article

References (40)

1. Reaven G,. Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes 1998; 37: 1559-1607.
2. Despres JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C,. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis 1990; 10: 497-511.
3. Ravussin E, Smith SR,. Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. Ann N Y Acad Sci 2002; 967: 363-378.
4. Danforth E, Jr., Failure of adipocyte differentiation causes type II diabetes mellitus? Nat Genet 2000; 26: 13.
5. Kursawe R, Eszlinger M, Narayan D, et al. Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis. Diabetes 2010; 59: 2288-2296.
6. Alligier M, Gabert L, Meugnier E, et al. Visceral fat accumulation during lipid overfeeding is related to subcutaneous adipose tissue characteristics in healthy men. J Clin Endocrinol Metab 2013; 98: 802-810.
7. Edens NK, Fried SK, Kral JG, Hirsch J, Leibel RL,. In vitro lipid synthesis in human adipose tissue from three abdominal sites. Am J Physiol 1993; 265: E374-E379.
8. Farnier C, Krief S, Blache M, et al. Adipocyte functions are modulated by cell size change: potential involvement of an integrin/ERK signalling pathway. Int J Obes Relat Metab Disord 2003; 27: 1178-1186.
9. Berman DM, Nicklas BJ, Ryan AS, Rogus EM, Dennis KE, Goldberg AP,. Regulation of lipolysis and lipoprotein lipase after weight loss in obese, postmenopausal women. Obes Res 2004; 12: 32-39.
10. Fried SK, Tittelbach T, Blumenthal J, et al. Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women. J Lipid Res 2010; 51: 1193-1200.
11. Ferrara CM, Lynch NA, Nicklas BJ, Ryan AS, Berman DM,. Differences in adipose tissue metabolism between postmenopausal and perimenopausal women. J Clin Endocrinol Metab 2002; 87: 4166-4170.
12. Nicklas BJ, Rogus EM, Berman DM, Dennis KE, Goldberg AP,. Responses of adipose tissue lipoprotein lipase to weight loss affect lipid levels and weight regain in women. Am J Physiol Endocrinol Metab 2000; 279: E1012-E1019.
13. Raison J, Basdevant A, Sitt Y, Guy-Grand B,. Regional differences in adipose tissue lipoprotein lipase activity in relation to body fat distribution and menopausal status in obese women. Int J Obes 1988; 12: 465-472.
14. Rebuffe-Scrive M, Enk L, Crona N, et al. Fat cell metabolism in different regions in women. Effect of menstrual cycle, pregnancy, and lactation. J Clin Investig 1985; 75: 1973-1976.
15. Grundy SM,. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2004; 89: 2595-2600.
16. Nicklas BJ, Dennis KE, Berman DM, Sorkin J, Ryan AS, Goldberg AP,. Lifestyle intervention of hypocaloric dieting and walking reduces abdominal obesity and improves coronary heart disease risk factors in obese, postmenopausal, African-American and Caucasian women. J Gerontol Ser A Biol Sci Med Sci 2003; 58: 181-189.
17. Ryan AS, Ortmeyer HK, Sorkin JD,. Exercise with calorie restriction improves insulin sensitivity and glycogen synthase activity in obese postmenopausal women with impaired glucose tolerance. Am J Physiol Endocrinol Metab 2012; 302: E145-E152.
18. Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112: 2735-2752.
19. Tataranni PA, Ravussin E,. Use of dual-energy X-ray absorptiometry in obese individuals. Am J Clin Nutr 1995; 62: 730-734.
20. Ryan AS, Nicklas BJ,. Age-related changes in fat deposition in mid-thigh muscle in women: relationships with metabolic cardiovascular disease risk factors. Int J Obes Relat Metab Disord 1999; 23: 126-132.
21. Nutrition Committee, American Heart Association. Dietary guidelines for healthy American adults. A statement for physicians and health professionals. Circulation 1988; 77: 721A-724A.
22. Nicklas BJ, Katzel LI, Bunyard LB, Dennis KE, Goldberg AP,. Effects of an American Heart Association diet and weight loss on lipoprotein lipids in obese, postmenopausal women. Am J Clin Nutr 1997; 66: 853-859.
23. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2012; 35 (Suppl 1): S64-S71.
24. Leibel RL, Hirsch J,. Site-and sex-related differences in adrenoreceptor status of human adipose tissue. J Clin Endocrinol Metab 1987; 64: 1205-1210.
25. Cook RD,. Influential observations in linear regression. J Am Stat Assoc 1979; 74: 169-174.
26. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC,. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
27. Wang H, Eckel RH,. Lipoprotein lipase: from gene to obesity. Am J Physiol Endocrinol Metab 2009; 297: E271-E288.
28. Kern PA, Ong JM, Saffari B, Carty J,. The effects of weight loss on the activity and expression of adipose-tissue lipoprotein lipase in very obese humans. N Engl J Med 1990; 322: 1053-1059.
29. Bluher M,. The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. Curr Opin Lipidol 2010; 21: 38-43.
30. Nishimura S, Manabe I, Nagasaki M, et al. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 2007; 56: 1517-1526.
31. Veilleux A, Caron-Jobin M, Noel S, Laberge PY, Tchernof A,. Visceral adipocyte hypertrophy is associated with dyslipidemia independent of body composition and fat distribution in women. Diabetes 2011; 60: 1504-1511.
32. Kashiwagi A, Mott D, Bogardus C, Lillioja S, Reaven GM, Foley JE,. The effects of short-term overfeeding on adipocyte metabolism in Pima Indians. Metab Clin Exp 1985; 34: 364-370.
33. Defronzo RA, Mehta RJ, Schnure JJ,. Pleiotropic effects of thiazolidinediones: implications for the treatment of patients with type 2 diabetes mellitus. Hosp Pract (1995) 2013; 41: 132-147.
34. Simoneau JA, Veerkamp JH, Turcotte LP, Kelley DE,. Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. FASEB J 1999; 13: 2051-2060.
35. Schwartz RS, Brunzell JD,. Increase of adipose tissue lipoprotein lipase activity with weight loss. J Clin Investig 1981; 67: 1425-1430.
36. Imbeault P, Almeras N, Richard D, Despres JP, Tremblay A, Mauriege P,. Effect of a moderate weight loss on adipose tissue lipoprotein lipase activity and expression: existence of sexual variation and regional differences. Int J Obes Relat Metab Disord 1999; 23: 957-965.
37. Seip RL, Angelopoulos TJ, Semenkovich CF,. Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue. Am J Physiol 1995; 268: E229-E236.
38. Ortmeyer HK, Ryan AS, Blumenthal JB, Joseph LJ, Goldberg AP,. Exercise and weight loss (WL), but not WL alone, affects skeletal muscle and adipose tissue lipoprotein lipase actvity in postmenopausal women. Diabetes 2006; 55: A5.
39. Porter SA, Massaro JM, Hoffmann U, Vasan RS, O'Donnel CJ, Fox CS,. Abdominal subcutaneous adipose tissue: a protective fat depot? Diabetes Care 2009; 32: 1068-1075.
40. Albu JB, Murphy L, Frager DH, Johnson JA, Pi-Sunyer FX,. Visceral fat and race-dependent health risks in obese nondiabetic premenopausal women. Diabetes 1997; 46: 456-462.