Propionibacterium acnes promotes Th17 and Th17/Th1 responses in acne patients

Journal of Investigative Dermatology

Volumn 135, Issue 1, 2015, Pages 110-118

  Kistowska, Magdalena ^a   Meier, Barbara ^a   Proust, Tatiana ^a   Feldmeyer, Laurence ^b   Cozzio, Antonio ^a   Kuendig, Thomas ^a   Contassot, Emmanuel ^a   French, Lars E ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 4; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STAT4 PROTEIN; STAT5A PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; IL12A PROTEIN, HUMAN; IL17A PROTEIN, HUMAN; INTERLEUKIN 12P35;

ACNE; ARTICLE; CD4+ T LYMPHOCYTE; CYTOKINE RELEASE; HUMAN; IN VITRO STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES; TH1 CELL; TH17 CELL; UPREGULATION; ACNE VULGARIS; ADULT; GRAM POSITIVE INFECTION; IMMUNOLOGY; IMMUNOPHENOTYPING; MALE; MICROBIOLOGY; MONOCYTE; YOUNG ADULT;

ACNE VULGARIS; ADULT; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-12 SUBUNIT P35; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKIN-23; MALE; MONOCYTES; PROPIONIBACTERIUM ACNES; TH1 CELLS; TH17 CELLS; YOUNG ADULT;

EID: 84925227839     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.290     Document Type: Article

References (38)

1. Acosta-Rodriguez EV, Rivino L, Geginat J et al. (2007) Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 8:639-46
2. Agak GW, Qin M, Nobe J et al. (2013) Propionibacterium acnes induces an IL-17 response in acne vulgaris that is regulated by vitamin A and vitamin D. J Invest Dermatol 134:366-73
3. Annunziato F, Cosmi L, Liotta F et al. (2012) Defining the human T helper 17 cell phenotype. Trends Immunol 33:505-12
4. Annunziato F, Cosmi L, Santarlasci V et al. (2007) Phenotypic and functional features of human Th17 cells. J Exp Med 204:1849-61
5. Asarch A, Barak O, Loo DS et al. (2008) Th17 cells: a new paradigm for cutaneous inflammation. J Dermatol Treat 19:259-66
6. Brodie T, Brenna E, Sallusto F (2013) OMIP-018: chemokine receptor expression on human T helper cells. Cytometry A 83:530-2
7. Bromley SK, Mempel TR, Luster AD (2008) Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol 9:970-80
8. Chung Y, Chang SH, Martinez GJ et al. (2009) Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30:576-87
9. Dileepan T, Linehan JL, Moon JJ et al. (2011) Robust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection. PLoS Pathog 7:e1002
10. Guo L, Wei G, Zhu J et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci USA 106:13463-8
11. Jappe U, Ingham E, Henwood J et al. (2002) Propionibacterium acnes and inflammation in acne; P. acnes has T-cell mitogenic activity. Br J Dermatol 146:202-9
12. Jeremy AH, Holland DB, Roberts SG et al. (2003) Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 121:20-7
13. Kalis C, Gumenscheimer M, Freudenberg N et al. (2005) Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes. J Immunol 174:4295-300
14. Kim J, Ochoa MT, Krutzik SR et al. (2002) Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 169:1535-41
15. Kistowska M, Gehrke S, Jankovic D et al. (2013) IL-1b drives inflammatory responses to Propionibacterium acnes in vitro and in vivo. J Invest Dermatol 134:677-85
16. Korn T, Bettelli E, Gao W et al. (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448:484-7
17. Laan M, Cui ZH, Hoshino H et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol 162: 2347-52
18. Layton AM, Morris C, Cunliffe WJ et al. (1998) Immunohistochemical investigation of evolving inflammation in lesions of acne vulgaris. Exp Dermatol 7:191-7
19. Leeming JP, Holland KT, Cuncliffe WJ (1988) The microbial colonization of inflamed acne vulgaris lesions. Br J Dermatol 118:203-8
20. Leyden JJ, McGinley KJ, Vowels B (1998) Propionibacterium acnes colonization in acne and nonacne. Dermatology 196:55-8
21. McGeachy MJ (2013) Th17 memory cells: live long and proliferate. J Leukoc Biol 94:921-6
22. Milner JD, Brenchley JM, Laurence A et al. (2008) Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 452:773-6
23. Miossec P, Kolls JK (2012) Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov 11:763-76
24. Mouser PE, Baker BS, Seaton ED et al. (2003) Propionibacterium acnes-reactive T helper-1 cells in the skin of patients with acne vulgaris. J Invest Dermatol 121:1226-8
25. Muranski P, Restifo NP (2013) Essentials of Th17 cell commitment and plasticity. Blood 121:2402-14
26. Nagy I, Pivarcsi A, Koreck A et al. (2005) Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. J Invest Dermatol 124:931-8
27. Norris JF, Cunliffe WJ (1988) A histological and immunocytochemical study of early acne lesions. Br J Dermatol 118:651-9
28. O'Connor W Jr., Zenewicz LA, Flavell RA (2010) The dual nature of T(H)17 cells: shifting the focus to function. Nat Immunol 11:471-6
29. Peck A, Mellins ED (2010) Precarious balance: Th17 cells in host defense. Infect Immun 78:32-8
30. Puel A, Cypowyj S, Bustamante J et al. (2011) Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 332:65-8
31. Trivedi NR, Gilliland KL, Zhao W et al. (2006) Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling. J Invest Dermatol 126:1071-9
32. Weaver CT, Hatton RD, Mangan PR et al. (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821-52
33. Wei L, Laurence A, Elias KM et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem 282:34605-10
34. Wilke CM, Bishop K, Fox D et al. (2011) Deciphering the role of Th17 cells in human disease. Trends Immunol 32:603-11
35. Ye P, Rodriguez FH, Kanaly S et al. (2001) Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colonystimulating factor expression, neutrophil recruitment, and host defense. J Exp Med 194:519-27
36. Zhu J, Paul WE (2008) CD4 T cells: fates, functions, and faults. Blood 112:1557-69
37. Zhu J, Yamane H, Paul WE (2010) Differentiation of effector CD4 T cell populations. Annu Rev Immunol 28:445-89
38. Zielinski CE, Mele F, Aschenbrenner D et al. (2012) Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Nature 484:514-8