Neurotoxicity following acute inhalation of aerosols generated during resistance spot weld-bonding of carbon steel

Inhalation Toxicology

Volumn 26, Issue 12, 2014, Pages 720-732

  Sriram, Krishnan ^a   Jefferson, Amy M ^a   Lin, Gary X ^a   Afshari, Aliakbar ^a   Zeidler Erdely, Patti C ^a   Meighan, Terence G ^a   Mckinney, Walter ^a   Jackson, Mark ^a   Cumpston, Amy ^a   Cumpston, Jared L ^a   Leonard, Howard D ^a   Frazer, David G ^a   Antonini, James M ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Aerosols; Manganese; Neurotoxicity; Occupational exposure; Parkinson's disease; Volatile organic compounds; Welding; Welding fume

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; CARBON; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 5 RECEPTOR; DOPAMINE TRANSPORTER; MESSENGER RNA; METAL OXIDE; NEUROTRANSMITTER; NORADRENALIN; OLFACTORY MARKER PROTEIN; SEROTONIN; STEEL; TYROSINE 3 MONOOXYGENASE; VOLATILE ORGANIC COMPOUND; ADHESIVE AGENT; AEROSOL; AIR POLLUTANT; BIOLOGICAL MARKER; NERVE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN FUNCTION; BRAIN REGION; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; ELECTROCHEMICAL DETECTION; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NERVOUS SYSTEM INFLAMMATION; NEUROTOXICITY; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; OLFACTORY BULB; PRIORITY JOURNAL; RAT; RESISTANCE SPOT WELDING; SEROTONIN BRAIN LEVEL; SPRAGUE DAWLEY RAT; WELDING; WELDING FUME; ADVERSE EFFECTS; AEROSOL; AIR POLLUTANT; ANIMAL; BRAIN; BRAIN CHEMISTRY; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; EXPOSURE; FIRE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; NERVE CELL; OXIDATION REDUCTION REACTION; PROCEDURES; TOXICITY; TOXICITY AND INTOXICATION; TOXICITY TESTING;

RATTUS;

ADHESIVES; AEROSOLS; AIR POLLUTANTS, OCCUPATIONAL; ANIMALS; BIOLOGICAL MARKERS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN CHEMISTRY; FIRES; GENE EXPRESSION REGULATION; INHALATION EXPOSURE; MALE; NERVE TISSUE PROTEINS; NEURONS; NEUROTOXICITY SYNDROMES; OLFACTORY BULB; OXIDATION-REDUCTION; RATS, SPRAGUE-DAWLEY; STEEL; TOXICITY TESTS, ACUTE; VOLATILE ORGANIC COMPOUNDS; WELDING;

EID: 84925197659     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2014.954654     Document Type: Article

References (76)

1. Afshari A, Zeidler-Erdely PC, McKinney M, et al. (2014). Development and characterization of a resistance spot welding aerosol generator and inhalation exposure system. Inhal Toxicol. DOI: 10.3109/ 08958378.2014.941118.
2. Balster RL. (1998). Neural basis of inhalant abuse. Drug Alcohol Depend 51:207-14.
3. Bazzoni G, Dejana E. (2004). Endothelial cell-To-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev 84:869-901.
4. Berendse HW, Booij J, Francot CM, et al. (2001). Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell. Ann Neurol 50: 34-41.
5. Bowler RM, Gysens S, Diamond E, et al. 2006. Manganese exposure: neuropsychological and neurological symptoms and effects in welders. Neurotoxicology 27:315-26.
6. Bowler RM, Nakagawa S, Drezgic M, et al. (2007a). Sequelae of fume exposure in confined space welding: a neurological and neuropsychological case series. Neurotoxicology 28:298-311.
7. Bowler RM, Roels HA, Nakagawa S, et al. (2007b). Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders. Occup Environ Med 64:167-77.
8. Buiakova OI, Krishna NS, Getchell TV, Margolis FL. (1994). Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. Genomics 20:452-62.
9. Buiakova OI, Baker H, Scott JW, et al. (1996). Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons. Proc Natl Acad Sci USA 93:9858-63.
10. Chang BH, Shi YW, Dong SJ. (1999). A study on the role of adhesives in weld-bonded joints. Welding J 78:275s-9s.
11. Chang JY, Liu LZ. (1999). Manganese potentiates nitric oxide production by microglia. Brain Res Mol Brain Res 68:22-8.
12. Chouaniere D, Wild P, Fontana JM, et al. (2002). Neurobehavioral disturbances arising from occupational toluene exposure. Am J Ind Med 41:77-88.
13. Deleu D, Hanssens Y. (2000). Cerebellar dysfunction in chronic toluene abuse: beneficial response to amantadine hydrochloride. J Toxicol Clin Toxicol 38:37-41.
14. Dick FD. (2006). Solvent neurotoxicity. Occup Environ Med 63:221-6.
15. Donaldson J. (1987). The physiopathologic significance of manganese in brain: its relation to schizophrenia and neurodegenerative disorders. Neurotoxicology 8:451-62.
16. Doty RL, Hastings L. (2000). Neurotoxic exposure and olfactory impairment. Clin Occup Environ Med 1:547-75.
17. Echeverria D, Fine L, Langolf G, et al. (1991). Acute behavioural comparisons of toluene and ethanol in human subjects. Br J Ind Med 48:750-61.
18. Elder A, Gelein R, Silva V, et al. (2006). Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect 114:1172-8.
19. Emara AM, el-Ghawabi SH, Madkour OI, el-Samra GH. (1971). Chronic manganese poisoning in the dry battery industry. Br J Ind Med 28: 78-82.
20. Filipov NM, Seegal RF, Lawrence DA. (2005). Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism. Toxicol Sci 84:139-48.
21. Finkelstein MM, Jerrett M. (2007). A study of the relationships between Parkinson's disease and markers of traffic-derived and environmental manganese air pollution in two Canadian cities. Environ Res 104: 420-32.
22. Halasz N, Ljungdahl A, Ho'kfelt T, et al. (1977). Transmitter histochemistry of the rat olfactory bulb. I. Immunohistochemical localization of monoamine synthesizing enzymes. Support for intrabulbar, periglomerular dopamine neurons. Brain Res 126:455-74.
23. Hammond SK, Gold E, Baker R, et al. (2005). Respiratory health effects related to occupational spray painting and welding. J Occup Environ Med 47:728-39.
24. Huber JD, Egleton RD, Davis TP. (2001). Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci 24:719-25.
25. Hunot S, Hartmann A, Hirsch EC. (2001). The inflammatory response in the Parkinson brain. Clin Neurosci Res 1:434-43.
26. Hunter DD, Undem BJ. (1999). Identification and substance P content of vagal afferent neurons innervating the epithelium of the guinea pig trachea. Am J Respir Crit Care Med 159:1943-8.
27. Jenkins NT, Pierce WM-G, Eagar TW. (2005). Particle size distribution of gas metal and flux cored arc welding fumes. Welding J 84: 156s-63s.
28. Jin BK, Franzen L, Baker H. (1996). Regulation of c-Fos mRNA and fos protein expression in olfactory bulbs from unilaterally odor-deprived adult mice. Int J Dev Neurosci 14:971-82.
29. Johnson BA, Woo CC, Ninomiya-Tsuboi K, Leon M. (1996). Synaptophysin-like immunoreactivity in the rat olfactory bulb during postnatal development and after restricted early olfactory experience. Brain Res Dev Brain Res 92:24-30.
30. Josephs KA, Ahlskog JE, Klos KJ, et al. (2005). Neurologic manifestations in welders with pallidal MRI T1 hyperintensity. Neurology 64: 2033-9.
31. Kamran S, Bakshi R. (1998). MRI in chronic toluene abuse: low signal in the cerebral cortex on T2-weighted images. Neuroradiology 40: 519-21.
32. Kanwal R, Boylstein RJ. (2006). NIOSH Health Hazard Evaluation Report: HETA# 2006-0059-3009, Daimler-Chrysler Jefferson North Assembly Plant, Detroit, MI. Washington, DC: DHHS/Center for Disease Control and Prevention.
33. Kiriu T, Ameno K, Fuke C, et al. (1990). The distribution of toluene in the brain and its effects on the brain catecholamines in acute toluene poisoning. Nihon Hoigaku Zasshi 44:25-33.
34. Kishi R, Harabuchi I, Katakura Y, et al. (1993). Neurobehavioral effects of chronic occupational exposure to organic solvents among Japanese industrial painters. Environ Res 62:303-13.
35. Kniesel U, Wolburg H. (2000). Tight junctions of the blood-brain barrier. Cell Mol Neurobiol 20:57-76.
36. Kosaka T, Hataguchi Y, Hama K, et al. (1985). Coexistence of immunoreactivities for glutamate decarboxylase and tyrosine hydroxylase in some neurons in the periglomerular region of the rat main olfactory bulb: possible coexistence of gamma-Aminobutyric acid (GABA) and dopamine. Brain Res 343:166-71.
37. Kruzich PJ, Grandy DK. (2004). Dopamine D2 receptors mediate two-odor discrimination and reversal learning in C57BL/6 mice. BMC Neurosci 5:12.
38. Lee YL, Pai MC, Chen JH, Guo YL. (2003). Central neurological abnormalities and multiple chemical sensitivity caused by chronic toluene exposure. Occup Med 53:479-82.
39. Long H. (2006). Inhalants. In: Goldfrank LR, Flomenbaum N, eds. Goldfranks' toxicologic emergencies. New York: McGraw-Hill, 1192-201.
40. Lopez-Ramirez MA, Fischer R, Torres-Badillo CC, et al. (2012). Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells. J Immunol 189:3130-9.
41. Loukzadeh Z, Sharifian SA, Aminian O, Shojaoddiny-Ardekani A. (2009). Pulmonary effects of spot welding in automobile assembly. Occup Med 59:267-9.
42. Lucchini R, Apostoli P, Perrone C, et al. (1999). Long-Term exposure to ''low levels'' of manganese oxides and neurofunctional changes in ferroalloy workers. Neurotoxicology 20:287-97.
43. Lucchini RG, Albini E, Benedetti L, et al. (2007). High prevalence of Parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries. Am J Ind Med 50:788-800.
44. Luo JCJ, Hsu K-H, Shen W-S. (2006). Pulmonary function abnormalities and airway irritation symptoms of metal fumes exposure on automotive spot welders. Am J Ind Med 49:407-16.
45. McGeer PL, McGeer EG. (2004). Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism Relat Disord 10:S3-7.
46. Mergler D, Baldwin M. (1997). Early manifestations of manganese neurotoxicity in humans: an update. Environ Res 73:92-100.
47. Miller Electric. (2012). Handbook for resistance spot welding. Appleton, WI: Miller Electric, 1-10.
48. Mogi M, Harada M, Riederer P, et al. (1994). Tumor necrosis factoralpha (TNF-Alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci Lett 165:208-10.
49. Murphy BL, Arnsten AF, Goldman-Rakic PS, Roth RH. (1996 Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proc Natl Acad Sci USA 93:1325-9.
50. Nabhen SL, Perfume G, Battistone MA, et al. (2009). Short-Term effects of endothelins on tyrosine hydroxylase activity and expression in the olfactory bulb of normotensive rats. Neurochem Res 34:953-63.
51. Nabhen SL, Guil MJ, Saffioti N, et al. (2013). Calcium-dependent mechanisms involved in the modulation of tyrosine hydroxylase by endothelins in the olfactory bulb of normotensive rats. Neurochem Int 62:389-98.
52. Nitta T, Hata M, Gotoh S, et al. (2003). Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 161: 653-60.
53. Oberdo'rster G, Sharp Z, Atudorei V, et al. (2002). Extrapulmonary translocation of ultrafine carbon particles following wholebody inhalation exposure of rats. J Toxicol Environ Health A 65: 1531-43.
54. Oberdorster G, Sharp Z, Atudorei V, et al. (2004). Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16:437-45.
55. Racette BA, McGee-Minnich L, Moerlein SM, et al. (2001). Weldingrelated parkinsonism: clinical features, treatment, and pathophysiology. Neurology 56:8-13.
56. Racette BA, Tabbal SD, Jennings D, et al. (2005). Prevalence of parkinsonism and relationship to exposure in a large sample of Alabama welders. Neurology 64:230-5.
57. Rodier J. (1955). Manganese poisoning in Moroccan miners. Br J Ind Med 12:21-35.
58. Sengupta A, Mense SM, Lan C, et al. (2007). Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells. Neurotoxicology 28: 478-89.
59. Sriram K, Matheson JM, Benkovic SA, et al. (2002). Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease. FASEB J 16: 1474-6.
60. Sriram K, Matheson JM, Benkovic SA, et al. (2006a). Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-Alpha. FASEB J 20:670-82.
61. Sriram K, Miller DB, O'Callaghan JP. (2006b). Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-Alpha. J Neurochem 96: 706-18.
62. Sriram K, Lin GX, Jefferson AM, et al. (2010a). Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes. Arch Toxicol 84:521-40.
63. Sriram K, Lin GX, Jefferson AM, et al. (2010b). Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes. FASEB J 24:4989-5002.
64. Streifel KM, Moreno JA, Hanneman WH, et al. (2012). Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice. Toxicol Sci 126:183-92.
65. Thiel VE, Audus KL. (2001). Nitric oxide and blood-brain barrier integrity. Antioxid Redox Signal 3:273-8.
66. Tillerson JL, Caudle WM, Parent JM, et al. (2006). Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor. Behav Brain Res 172:97-105.
67. Ueno M, Sakamoto H, Liao YJ, et al. (2004). Blood-brain barrier disruption in the hypothalamus of young adult spontaneously hypertensive rats. Histochem Cell Biol 122:131-7.
68. von Euler G, Ogren SO, Li XM, et al. (1993). Persistent effects of subchronic toluene exposure on spatial learning and memory, dopamine mediated locomotor activity and dopamine D2 agonist binding in the rat. Toxicology 77:223-32.
69. von Euler M, Pham TM, Hillefors M, et al. (2000). Inhalation of low concentrations of toluene induces persistent effects on a learning retention task, beam-walk performance, and cerebrocortical size in the rat. Exp Neurol 163:1-8.
70. Wang JD, Chen JD. (1993). Acute and chronic neurological symptoms among paint workers exposed to mixtures of organic solvents. Environ Res 61:107-16.
71. Wennberg A, Iregren A, Struwe G, et al. (1991). Manganese exposure in steel smelters a health hazard to the nervous system. Scand J Work Environ Health 17:255-62.
72. White RF, Proctor SP. (1997). Solvents and neurotoxicity. Lancet 349: 1239-43.
73. Wilson DA, Sullivan RM. (1995). The D2 antagonist spiperone mimics the effects of olfactory deprivation on mitral/tufted cell odor response patterns. J Neurosci 15:5574-81.
74. Yamanouchi N, Okada S, Kodama K, et al. (1995). White matter changes caused by chronic solvent abuse. Am J Neuroradiol 16:1643-9.
75. Yu IT, Lee NL, Zhang XH, et al. (2004). Occupational exposure to mixtures of organic solvents increases the risk of neurological symptoms among printing workers in Hong Kong. J Occup Environ Med 46:323-30.
76. Zimmer AT, Biswas P. (2001). Characterization of the aerosols resulting from arc welding processes. J Aerosol Sci 32:993-1008.