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Volumn 44, Issue 7, 2001, Pages 1025-1027

Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: Potential agents for treatment of erectile dysfunction

(14) Yu, G a Mason, H J a Wu, X a Wang, J a Chong, S a Dorough, G a Henwood, A a Pongrac, R a Seliger, L a He, B a Normandin, D a Adam, L a Krupinski, J a Macor, J E a

a BRISTOL MYERS SQUIBB (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PYRAZOLOPYRIDINE DERIVATIVE; SILDENAFIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DOG; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ERECTILE DYSFUNCTION; FEMALE; IC 50; IN VITRO STUDY; LETTER; MALE; NONHUMAN; RABBIT; RAT;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ADMINISTRATION, ORAL; ANIMALS; DOGS; IMPOTENCE; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PENIS; PHOSPHODIESTERASE INHIBITORS; PYRIDINES; RABBITS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035966869 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm0155042 Document Type: Letter

Times cited : (48)

References (15)

1
- 0030999960
- (1997) Drugs Future , vol.22 , pp. 138-143

2
- 0030572496
- Sildenafil (Viagra), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
- (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 1819-1824
- Terrett, N.K.¹ Bell, A.S.² Brown, D.³ Ellis, P.⁴

3
- 0030154874
- Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
- (1996) Int. J. Urol. Res. , vol.8 , pp. 47-52
- Boolell, M.¹ Allen, M.J.² Ballard, S.A.³ Gepi-Attee, S.⁴ Muirhead, G.J.⁵ Naylor, A.M.⁶ Osterloh, I.H.⁷ Gingell, C.⁸

4
- 0030699165
- The role of phosphodiesterase inhibitors in impotence
- (1997) Exp. Opin. Invest. Drugs , vol.6 , pp. 1803-1810
- Eardley, I.¹

5
- 0030815953
- Drugs for the treatment of impotence
- (1997) Drugs Aging , vol.11 , pp. 140-151
- Garcia-Reboll, L.¹ Mulhall, J.P.² Goldstein, I.³

6
- 0031736771
- Phosphodiesterase inhibitors in the treatment of erectile dysfunction
- (1998) Drugs Today , vol.34 , pp. 805-812
- Truss, M.C.¹ Stief, C.G.²

7
- 0028802726
- Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
- (1995) Physiol. Rev. , vol.75 , pp. 725-748
- Beavo, J.A.¹

8
- 0003916506
- October 9
- (1997) Scrip

9
- 0028837352
- Physiology of penile erection
- (1995) Physiol. Rev. , vol.75 , pp. 191-236
- Andersson, K.-E.¹ Wagner, G.²

10
- 0033553509
- Cyclic GMP phosphodiesterase-5: Target of sildenafil
- (1999) J. Biol. Chem. , vol.274 , pp. 13729-13732
- Corbin, J.D.¹ Francis, S.H.²

11
- 0003851065
- U.S. Patent 5488055 1996, 22 pp
- Preparation of N-cycloalkylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines as c-GMP phosphodiesterase inhibitors
- Kumar, V.¹ Dority J.A., Jr.²

12
- 0034729784
- 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: Synthesis and inhibitory activity toward phosphodiesterase 5
- (2000) J. Med. Chem. , vol.43 , pp. 2523-2529
- Watanabe, N.¹ Adachi, H.² Takase, Y.³ Ozaki, H.⁴ Matsukura, M.⁵ Miyazaki, K.⁶ Ishibashi, K.⁷ Ishihara, H.⁸ Kodama, K.⁹ Nishino, M.¹⁰ Kakiki, M.¹¹ Kabasawa, Y.¹²

13
- 0034611619
- N-3-substituted imidazoquinazolinones: Potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction
- (2000) J. Med. Chem. , vol.43 , pp. 1257-1263
- Rotella, D.¹ Sun, Z.² Zhu, Y.³ Krupinski, J.⁴ Pongrac, R.⁵ Seliger, L.⁶ Normandin, D.⁷ Macor, J.E.⁸

14
- 0003939693
- note

15
- 0003853638
- note

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.