4-(3-Chloro-4-methoxybenzyl)aminophthalazines: Synthesis and inhibitory activity toward phosphodiesterase 5

Journal of Medicinal Chemistry

Volumn 43, Issue 13, 2000, Pages 2523-2529

  Watanabe, Nobuhisa ^a   Adachi, Hideyuki ^a   Takase, Yasutaka ^a   Ozaki, Hirofumi ^a   Matsukura, Masayuki ^a   Miyazaki, Kazuki ^a   Ishibashi, Keiji ^a   Ishihara, Hiroki ^a   Kodama, Kohtarou ^a   Nishino, Mayu ^a   Kakiki, Motoharu ^a   Kabasawa, Yasuhiro ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

[4 (3 CHLORO 4 METHOXYBENZYL)AMINO 1 (4 HYDROXY)PIPERIDINO] 6 PHTHALAZINECARBONITRILE; PHOSPHODIESTERASE INHIBITOR; PHTHALAZINE DERIVATIVE; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL TISSUE; ARTICLE; CORONARY ARTERY DILATATION; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; SWINE; VASODILATATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; CORONARY VESSELS; DINOPROST; HYPERTENSION, PULMONARY; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PHTHALAZINES; PIPERIDINES; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; VASODILATOR AGENTS;

EID: 0034729784     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9905054     Document Type: Article

References (21)

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