Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: Scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 22, 2014, Pages 5175-5180

  Sakamoto, Toshiaki ^a   Koga, Yuichi ^a   Hikota, Masataka ^a   Matsuki, Kenji ^a   Murakami, Michino ^a   Kikkawa, Kohei ^a   Fujishige, Kotomi ^a   Kotera, Jun ^a   Omori, Kenji ^a,b   Morimoto, Hiroshi ^a   Yamada, Koichiro ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

Erectile dysfunction; Intramolecular hydrogen bond; PDE5; PDE6; Pseudo ring

Indexed keywords

5 (3,4,5 TRIMETHOXYBENZOYL) 4 AMIMOPYRIMIDINE DERIVATIVE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VI; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; 4-AMINOPYRIMIDINE;

ARTICLE; CORPUS CAVERNOSUM; DRUG ACTIVITY; DRUG SYNTHESIS; HYDROGEN BOND; IC50; RABBIT; ANIMAL; ANTAGONISTS AND INHIBITORS; BOVINE; DOG; DRUG DESIGN; HUMAN; SYNTHESIS;

ANIMALS; CATTLE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6; DOGS; DRUG DESIGN; HUMANS; HYDROGEN BONDING; PHOSPHODIESTERASE 5 INHIBITORS; PYRIMIDINES; RABBITS;

EID: 84908412758     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.09.082     Document Type: Article

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