Adverse effects of vitamin d deficiency on outcomes of patients with chronic hepatitis B

Clinical Gastroenterology and Hepatology

Volumn 13, Issue 4, 2015, Pages 783-790.e1

  Wong, Grace Lai Hung ^a   Chan, Henry Lik Yuen ^a   Chan, Hoi Yun ^a   Tse, Chi Hang ^a   Chim, Angel Mei Ling ^a   Lo, Angeline Oi Shan ^a   Wong, Vincent Wai Sun ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

HBV; HCC; Hepatic Event; Liver Cancer; Mortality

Indexed keywords

CALCIFEDIOL; HEPATITIS B(E) ANTIGEN; VIRUS DNA; ANTIVIRUS AGENT;

ADULT; ADVERSE OUTCOME; AGE; ANTIVIRAL THERAPY; ARTICLE; CONTROLLED STUDY; DEATH; FEMALE; FOLLOW UP; HEPATITIS B; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; RISK FACTOR; SENSITIVITY ANALYSIS; SEX; VIRUS LOAD; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; COHORT ANALYSIS; COMPLICATION; DISEASE COURSE; HEPATITIS B, CHRONIC; MIDDLE AGED; PATHOLOGY; PROSPECTIVE STUDY;

ADULT; ANTIVIRAL AGENTS; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; VITAMIN D DEFICIENCY;

EID: 84925063565     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2014.09.050     Document Type: Article

References (31)

1. Dienstag J.L. Hepatitis B virus infection. NEngl J Med 2008, 359:1486-1500.
2. Chan H.L., Sung J.J. Hepatocellular carcinoma and hepatitis B virus. Semin Liver Dis 2006, 26:153-161.
3. Wong G.L., Wong V.W. Risk prediction of hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy. World J Gastroenterol 2013, 19:6515-6522.
4. Sung J.J., Tsoi K.K., Wong V.W., et al. Meta-analysis: treatment of hepatitis B infection reduces risk of hepatocellular carcinoma. Aliment Pharmacol Ther 2008, 28:1067-1077.
5. Wong G.L., Chan H.L., Mak C.W., et al. Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients with liver cirrhosis. Hepatology 2013, 58:1537-1547.
6. Wong G.L., Yiu K.K., Wong V.W., et al. Meta-analysis: reduction in hepatic events following interferon-alfa therapy of chronic hepatitis B. Aliment Pharmacol Ther 2010, 32:1059-1068.
7. Rosen C.J. Clinical practice: vitamin D insufficiency. NEngl J Med 2011, 364:248-254.
8. Schiefke I., Fach A., Wiedmann M., et al. Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infection. World J Gastroenterol 2005, 11:1843-1847.
9. Fisher L., Fisher A. Vitamin D and parathyroid hormone in outpatients with noncholestatic chronic liver disease. Clin Gastroenterol Hepatol 2007, 5:513-520.
10. Arteh J., Narra S., Nair S. Prevalence of vitamin D deficiency in chronic liver disease. Dig Dis Sci 2010, 55:2624-2628.
11. Farnik H., Bojunga J., Berger A., et al. Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients. Hepatology 2013, 58:1270-1276.
12. Petta S., Camma C., Scazzone C., et al. Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C. Hepatology 2010, 51:1158-1167.
13. Chan H.L., Hui A.Y., Wong M.L., et al. Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma. Gut 2004, 53:1494-1498.
14. Chan H.L., Leung N.W., Hussain M., et al. Hepatitis B e antigen-negative chronic hepatitis B in Hong Kong. Hepatology 2000, 31:763-768.
15. Chan H.L., Chui A.K., Lau W.Y., et al. Factors associated with viral breakthrough in lamivudine monoprophylaxis of hepatitis B virus recurrence after liver transplantation. JMed Virol 2002, 68:182-187.
16. Chan H.L., Thompson A., Martinot-Peignoux M., et al. Hepatitis B surface antigen quantification: why and how to use it in 2011-a core group report. JHepatol 2011, 55:1121-1131.
17. Bruix J., Sherman M. American Association for the Study of Liver Disease. Management of hepatocellular carcinoma: an update. Hepatology 2011, 53:1020-1022.
18. Powe C.E., Evans M.K., Wenger J., et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. NEngl J Med 2013, 369:1991-2000.
19. Lai C.L., Ratziu V., Yuen M.F., et al. Viral hepatitis B. Lancet 2003, 362:2089-2094.
20. Wong G.L., Chan H.L., Chan H.Y., et al. Accuracy of risk scores for patients with chronic hepatitis B receiving entecavir treatment. Gastroenterology 2013, 144:933-944.
21. Messa P., Alfieri C., Rastaldi M.P. Recent insights into vitamin D and its receptor. JNephrol 2011, 24(Suppl 18):S30-S37.
22. Stokes C.S., Volmer D.A., Grunhage F., et al. Vitamin D in chronic liver disease. Liver Int 2013, 33:338-352.
23. Collier J.D., Ninkovic M., Compston J.E. Guidelines on the management of osteoporosis associated with chronic liver disease. Gut 2002, 50(Suppl 1):i1-i9.
24. Bitetto D., Fabris C., Fornasiere E., et al. Vitamin D supplementation improves response to antiviral treatment for recurrent hepatitis C. Transpl Int 2011, 24:43-50.
25. Lange C.M., Bojunga J., Ramos-Lopez E., et al. Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy. JHepatol 2011, 54:887-893.
26. Abu-Mouch S., Fireman Z., Jarchovsky J., et al. Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-naive patients. World J Gastroenterol 2011, 17:5184-5190.
27. Nimer A., Mouch A. Vitamin D improves viral response in hepatitis C genotype 2-3 naive patients. World J Gastroenterol 2012, 18:800-805.
28. von Essen M.R., Kongsbak M., Schjerling P., et al. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol 2010, 11:344-349.
29. Crawford B.A., Kam C., Donaghy A.J., et al. The heterogeneity of bone disease in cirrhosis: a multivariate analysis. Osteoporos Int 2003, 14:987-994.
30. Miroliaee A., Nasiri-Toosi M., Khalilzadeh O., et al. Disturbances of parathyroid hormone-vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study. Hepatol Int 2010, 4:634-640.
31. Monegal A., Navasa M., Guanabens N., et al. Osteoporosis and bone mineral metabolism disorders in cirrhotic patients referred for orthotopic liver transplantation. Calcif Tissue Int 1997, 60:148-154.