Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy

Journal of Hepatology

Volumn 54, Issue 5, 2011, Pages 887-893

  Lange, Christian Markus ^a   Bojunga, Jörg ^a   Ramos Lopez, Elizabeth ^a   Von Wagner, Michael ^a   Hassler, Angela ^a   Vermehren, Johannes ^a   Herrmann, Eva ^b   Badenhoop, Klaus ^a   Zeuzem, Stefan ^a   Sarrazin, Christoph ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

1 Hydroxylase polymorphism; Antiviral therapy; HCV genotype; Hepatitis C virus; Pegylated interferon alfa; Vitamin D deficiency; Vitamin D receptor polymorphism

Indexed keywords

AMANTADINE; CALCIFEDIOL; CALCITRIOL; CYTOCHROME P 450 27B1; OXYGENASE; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D RECEPTOR;

ADULT; AGED; ARTICLE; COMORBIDITY; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HEPATITIS C; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; TREATMENT RESPONSE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ADULT; AGED; ANTIVIRAL AGENTS; CALCIFEDIOL; DRUG RESISTANCE, VIRAL; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RECEPTORS, CALCITRIOL; RETROSPECTIVE STUDIES; VITAMIN D DEFICIENCY; YOUNG ADULT;

EID: 79954669573     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.08.036     Document Type: Article

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