A Key Opinion Leader interview: Insight into the research and career of Prof. Claudiu T Supuran

Expert Opinion on Therapeutic Patents

Volumn 25, Issue 4, 2015, Pages 501-505

  Palmer, Claudia ^a   Supuran, Claudiu T ^b  

^a Expert Opinion Series Informa Healthcare Court ^*  (United Kingdom)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic andhydrases; CAs; Medicinal chemistry; Patents

Indexed keywords

ACETAZOLAMIDE; ANTICONVULSIVE AGENT; ANTIGLAUCOMA AGENT; ANTINEOPLASTIC AGENT; BICARBONATE; CARBON DIOXIDE; CARBONATE DEHYDRATASE; DITHIOCARBAMIC ACID; POLYAMINE; SULFANILAMIDE; SULFONAMIDE; XANTHIC ACID DERIVATIVE; ENZYME INHIBITOR;

CAREER; CATALYSIS; CHEMICAL REACTION; CRYSTAL STRUCTURE; HUMAN; INTROSPECTION; LEADERSHIP; MOLECULAR BIOLOGY; NOTE; PH; RESEARCH; SOLID TUMOR; STOMACH ULCER; SYNTHESIS; X RAY CRYSTALLOGRAPHY; DRUG DESIGN; INTERVIEW; MEDICAL RESEARCH; PATENT; PROCEDURES;

BIOMEDICAL RESEARCH; CARBONIC ANHYDRASES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; PATENTS AS TOPIC;

EID: 84924970679     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2015.1027045     Document Type: Note

References (28)

1. Puşcaş I. Treatment of gastroduodenal ulcer by "Ulcosilvanil". Med Interne 1987;25:135-43
2. Balaban AT. Professor Claudiu Supuran, a highly cited chemist and biochemist. Rev Chim (Bucharest) 2014;65:741-3
3. Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Disc 2008;7:168-81
4. Del Prete S, Vullo D, Fisher GM, et al. Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum - the -carbonic anhydrases. Bioorg Med Chem Lett 2014;24:4389-96
5. Neri D, Supuran CT. Interfering with pH regulation in tumours as a therapeutic strategy. Nat Rev Drug Discov 2011;10:767-77
6. Monti SM, Supuran CT, De Simone G. Anticancer carbonic anhydrase inhibitors: a patent review (2008-2013). Expert Opin Ther Pat 2013;23:737-49
7. Scozzafava A, Supuran CT, Carta F. Antiobesity carbonic anhydrase inhibitors: a literature and patent review. Expert Opin Ther Pat 2013;23:725-35
8. Capasso C, Supuran CT. Antiinfective carbonic anhydrase inhibitors: a patent and literature review. Expert Opin Ther Pat 2013;23:693-704
9. Bilginer S, Unluer E, Gul HI, et al. Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridylethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase. J Enzyme Inhib Med Chem 2014;29:495-9
10. Pan P, Vermelho AB, Capaci Rodrigues G, et al. Cloning, characterization, and sulfonamide and thiol inhibition studies of an alpha-carbonic anhydrase from Trypanosoma cruzi, the causative agent of chagas disease. J Med Chem 2013;56:1761-71
11. Syrjanen L, Vermelho AB, de Almeida Rodrigues I, et al. Cloning, characterization and inhibition studies of a beta carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible of leishmaniasis. J Med Chem 2013;56:7372-81
12. Del Prete S, De Luca V, Scozzafava A, et al. Biochemical properties of a new α-carbonic anhydrase from the human pathogenic bacterium Vibrio cholerae. J Enzyme Inhib Med Chem 2014;29:23-7
13. Supuran CT. Bacterial carbonic anhydrases as drug targets: towards novel antibiotics? Front Pharmacol 2011;2:34
14. Hall RA, Vullo D, Innocenti A, et al. External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans. Mol Biochem Parasitol 2008;161:140-9
15. Alterio V, Di Fiore A, D'Ambrosio K, et al. Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms? Chem Rev 2012;112:4421-68
16. Available from: http://www.topitalianscientists.org/Top-italian-scientists-VIA-Academy.aspx
17. Supuran CT. Structure-based drug discovery of carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem 2012;27:759-72
18. Supuran CT. Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnologic use for CO2 capture. J Enzyme Inhib Med Chem 2013;28:229-30
19. C¸avdar H, Ekinci D, Talaz O, et al. α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters. J Enzyme Inhib Med Chem 2012;27:148-54
20. Tanc M, Carta F, Scozzafava A, Supuran CT. α-Carbonic anhydrases possess thioesterase activity. ACS Med Chem Lett 2015; In press. doi: 10.1021/ml500470b
21. Maresca A, Temperini C, Vu H, et al. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J Am Chem Soc 2009;131:3057-62
22. Carta F, Temperini C, Innocenti A, et al. Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem 2010;53:5511-22
23. Maresca A, Carta F, Vullo D, Supuran CT. Dithiocarbamates strongly inhibit the beta-class carbonic anhydrases from Mycobacterium tuberculosis. J Enzyme Inhib Med Chem 2013;28:407-11
24. Carta F, Akdemir A, Scozzafava A, et al. Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo. J Med Chem 2013;56:4691-700
25. Supuran CT, Capasso C. The η-class carbonic anhydrases as drug targets for antimalarial agents. Expert Opin Ther Targets 2014;1-13. [Epub ahead of print]
26. Del Prete S, De Luca V, Vullo D, et al. Biochemical characterization of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis, PgiCA. J Enzyme Inhib Med Chem 2014;29:532-7
27. Supuran CT, Briganti F, Tilli S, et al. Carbonic anhydrase inhibitors: sulfonamides as antitumor agents? Bioorg Med Chem 2001;9:703-14
28. Lehneck R, Neumann P, Vullo D, et al. Crystal structure of two tetrameric carbonic anhydrases from the filamentous ascomycete Sordaria macrospora. FEBS J 2014;281:1759-72