Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature

Sleep Medicine Reviews

Volumn 20, Issue , 2015, Pages 15-26

  Hoyos, Camilla M ^a   Melehan, Kerri L ^a,b   Liu, Peter Y ^c   Grunstein, Ronald R ^a,b   Phillips, Craig L ^a,d  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^d ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Cardiovascular disease; Endothelial dysfunction; Obstructive sleep apnea

Indexed keywords

BLOOD VESSEL REACTIVITY; ENDOTHELIAL DYSFUNCTION; HUMAN; MEDLINE; METABOLIC SYNDROME X; POSITIVE END EXPIRATORY PRESSURE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SLEEP DISORDERED BREATHING; VASODILATATION; CARDIOVASCULAR DISEASES; COMPLICATION; MALE; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM;

CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; HUMANS; MALE; SLEEP APNEA, OBSTRUCTIVE;

EID: 84924965105     PISSN: 10870792     EISSN: 15322955     Source Type: Journal    
DOI: 10.1016/j.smrv.2014.06.003     Document Type: Review

References (116)

1. Marshall N.S., Wong K.K., Liu P.Y., Cullen S.R., Knuiman M.W., Grunstein R.R. Sleep apnea as an independent risk factor for all-cause mortality: the Busselton health study. Sleep 2008, 31:1079-1085.
2. Young T., Finn L., Peppard P.E., Szklo-Coxe M., Austin D., Nieto F.J., et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep 2008, 31:1071-1078.
3. Punjabi N.M., Caffo B.S., Goodwin J.L., Gottlieb D.J., Newman A.B., O'Connor G.T., et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med 2009, 6:e1000132.
4. Redline S., Yenokyan G., Gottlieb D.J., Shahar E., O'Connor G.T., Resnick H.E., et al. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med 2010, 182:269-277.
5. Munoz R., Duran-Cantolla J., Martinez-Vila E., Gallego J., Rubio R., Aizpuru F., et al. Severe sleep apnea and risk of ischemic stroke in the elderly. Stroke 2006, 37:2317-2321.
6. Gottlieb D.J., Yenokyan G., Newman A.B., O'Connor G.T., Punjabi N.M., Quan S.F., et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation 2010, 122:352-360.
7. William L.B.J., Loke Y., Kwok C.S., Niruban A., Myint P. Association of obstructive sleep apnoea (OSA) with incident stroke: a systematic review and meta-analysis. JNeurol Neurosurg Psychiatr 2013, 84:e2.
8. Wang X., Ouyang Y., Wang Z., Zhao G., Liu L., Bi Y. Obstructive sleep apnea and risk of cardiovascular disease and all-cause mortality: a meta-analysis of prospective cohort studies. Int J Cardiol 2013, 169(3):207-214.
9. Poredos P. Endothelial dysfunction in the pathogenesis of atherosclerosis. Clin Appl Thromb Hemost 2001, 7:276-280.
10. Yeboah J., Crouse J.R., Hsu F.C., Burke G.L., Herrington D.M. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular health study. Circulation 2007, 115:2390-2397.
11. Rossi R., Nuzzo A., Origliani G., Modena M.G. Prognostic role of flow-mediated dilation and cardiac risk factors in post-menopausal women. JAm Coll Cardiol 2008, 51:997-1002.
12. Foster G.E., Poulin M.J., Hanly P.J. Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea. Exp Physiol 2007, 92:51-65.
13. Alonso-Fernandez A., Garcia-Rio F., Arias M.A., Hernanz A., de la Pena M., Pierola J., et al. Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial. Thorax 2009, 64:581-586.
14. Ip M.S., Lam B., Chan L.Y., Zheng L., Tsang K.W., Fung P.C., et al. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med 2000, 162:2166-2171.
15. Schulz R., Schmidt D., Blum A., Lopes-Ribeiro X., Lucke C., Mayer K., et al. Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy. Thorax 2000, 55:1046-1051.
16. Noda A., Nakata S., Koike Y., Miyata S., Kitaichi K., Nishizawa T., et al. Continuous positive airway pressure improves daytime baroreflex sensitivity and nitric oxide production in patients with moderate to severe obstructive sleep apnea syndrome. Hypertens Res 2007, 30:669-676.
17. Ozkan Y., Firat H., Simsek B., Torun M., Yardim-Akaydin S. Circulating nitric oxide (NO), asymmetric dimethylarginine (ADMA), homocysteine, and oxidative status in obstructive sleep apnea-hypopnea syndrome (OSAHS). Sleep Breath 2008, 12:149-154.
18. Lavie L., Hefetz A., Luboshitzky R., Lavie P. Plasma levels of nitric oxide and L-arginine in sleep apnea patients: effects of nCPAP treatment. JMol Neurosci 2003, 21:57-63.
19. Lavie L. Obstructive sleep apnoea syndrome-an oxidative stress disorder. Sleep Med Rev 2003, 7:35-51.
20. Gozal D., Kheirandish-Gozal L. Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more. Am J Respir Crit Care Med 2008, 177:369-375.
21. Somers V.K., Dyken M.E., Clary M.P., Abboud F.M. Sympathetic neural mechanisms in obstructive sleep apnea. JClin Invest 1995, 96:1897-1904.
22. Leuenberger U., Jacob E., Sweer L., Waravdekar N., Zwillich C., Sinoway L. Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia. JAppl Physiol 1995, 79:581-588.
23. Hijmering M.L., Stroes E.S., Olijhoek J., Hutten B.A., Blankestijn P.J., Rabelink T.J. Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. JAm Coll Cardiol 2002, 39:683-688.
24. Zamarron-Sanz C., Ricoy-Galbaldon J., Gude-Sampedro F., Riveiro-Riveiro A. Plasma levels of vascular endothelial markers in obstructive sleep apnea. Arch Med Res 2006, 37:552-555.
25. Ohga E., Nagase T., Tomita T., Teramoto S., Matsuse T., Katayama H., et al. Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome. JAppl Physiol 1999, 87:10-14.
26. Ayers L., Stoewhas A.C., Ferry B., Stradling J., Kohler M. Elevated levels of endothelial cell-derived microparticles following short-term withdrawal of continuous positive airway pressure in patients with obstructive sleep apnea: data from a randomized controlled trial. Respiration 2013, 85:478-485.
27. Priou P., Gagnadoux F., Tesse A., Mastronardi M.L., Agouni A., Meslier N., et al. Endothelial dysfunction and circulating microparticles from patients with obstructive sleep apnea. Am J Pathol 2010, 177:974-983.
28. Phillips C.L., McEwen B.J., Morel-Kopp M.C., Yee B.J., Sullivan D.R., Ward C.M., et al. Effects of continuous positive airway pressure on coagulability in obstructive sleep apnoea: a randomised, placebo-controlled crossover study. Thorax 2012, 67:639-644.
29. Mehra R., Xu F., Babineau D.C., Tracy R.P., Jenny N.S., Patel S.R., et al. Sleep-disordered breathing and prothrombotic biomarkers: cross-sectional results of the Cleveland family study. Am J Respir Crit Care Med 2010, 182:826-833.
30. Berger S., Lavie L. Endothelial progenitor cells in cardiovascular disease and hypoxia-potential implications to obstructive sleep apnea. Transl Res 2011, 158:1-13.
31. Minville C., Hilleret M.N., Tamisier R., Aron-Wisnewsky J., Clement K., Trocme C., et al. Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea. Chest 2014, 145:525-533.
32. Kohler M., Stradling J.R. Mechanisms of vascular damage in obstructive sleep apnea. Nat Rev Cardiol 2010, 7:677-685.
33. Feng J., Zhang D., Chen B. Endothelial mechanisms of endothelial dysfunction in patients with obstructive sleep apnea. Sleep Breath 2012, 16:283-294.
34. Ali S.S., Oni E.T., Warraich H.J., Blaha M.J., Blumenthal R.S., Karim A., et al. Systematic review on noninvasive assessment of subclinical cardiovascular disease in obstructive sleep apnea: new kid on the block!. Sleep Med Rev 2014, 18:379-391. pii: S1087-0792(14)00014-8. http://dx.doi.org/10.1016/j.smrv.2014.01.004.
35. Amra B., Karbasi E., Hashemi M., Hoffmann-Castendiek B., Golshan M. Endothelial dysfunction in patients with obstructive sleep apnoea independent of metabolic syndrome. Ann Acad Med Singap 2009, 38:461-464.
36. Akishita M., Ohike Y., Yamaguchi Y., Iijima K., Eto M., Ouchi Y. Obstructive sleep apnea exacerbates endothelial dysfunction in people with metabolic syndrome. JAm Geriatr Soc 2011, 59:1565-1566.
37. Celermajer D.S. Reliable endothelial function testing: at our fingertips?. Circulation 2008, 117:2428-2430.
38. Celermajer D.S., Sorensen K.E., Gooch V.M., Spiegelhalter D.J., Miller O.I., Sullivan I.D., et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992, 340:1111-1115.
39. Corretti M.C., Anderson T.J., Benjamin E.J., Celermajer D., Charbonneau F., Creager M.A., et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. JAm Coll Cardiol 2002, 39:257-265.
40. Wilkinson I.B., Hall I.R., MacCallum H., Mackenzie I.S., McEniery C.M., van der Arend B.J., et al. Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function. Arterioscler Thromb Vasc Biol 2002, 22:147-152.
41. Wilkinson I.B., Webb D.J. Venous occlusion plethysmography in cardiovascular research: methodology and clinical applications. Br J Clin Pharmacol 2001, 52:631-646.
42. Turner J., Belch J.J., Khan F. Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis. Trends Cardiovasc Med 2008, 18:109-116.
43. Gori T., Di Stolfo G., Sicuro S., Dragoni S., Lisi M., Parker J.D., et al. Correlation analysis between different parameters of conduit artery and microvascular vasodilation. Clin Hemorheol Microcirc 2006, 35:509-515.
44. Hamburg N.M., Palmisano J., Larson M.G., Sullivan L.M., Lehman B.T., Vasan R.S., et al. Relation of brachial and digital measures of vascular function in the community: the Framingham heart study. Hypertension 2011, 57:390-396.
45. Namtvedt S.K., Hisdal J., Randby A., Agewall S., Stranden E., Somers V.K., et al. Impaired endothelial function in persons with obstructive sleep apnoea: impact of obesity. Heart 2013, 99:30-34.
46. Faulx M.D., Larkin E.K., Hoit B.D., Aylor J.E., Wright A.T., Redline S. Sex influences endothelial function in sleep-disordered breathing. Sleep 2004, 27:1113-1120.
47. Nieto F.J., Herrington D.M., Redline S., Benjamin E.J., Robbins J.A. Sleep apnea and markers of vascular endothelial function in a large community sample of older adults. Am J Respir Crit Care Med 2004, 169:354-360.
48. Chami H.A., Keyes M.J., Vita J.A., Mitchell G.F., Larson M.G., Fan S., et al. Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing. Vasc Med 2009, 14:351-360.
49. Mannion T.C., Vita J.A., Keaney J.F., Benjamin E.J., Hunter L., Polak J.F. Non-invasive assessment of brachial artery endothelial vasomotor function: the effect of cuff position on level of discomfort and vasomotor responses. Vasc Med 1998, 3:263-267.
50. Tanriverdi H., Evrengul H., Kara C.O., Kuru O., Tanriverdi S., Ozkurt S., et al. Aortic stiffness, flow-mediated dilatation and carotid intima-media thickness in obstructive sleep apnea: non-invasive indicators of atherosclerosis. Respiration 2006, 73:741-750.
51. Jelic S., Lederer D.J., Adams T., Padeletti M., Colombo P.C., Factor P., et al. Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea. Vasc Health Risk Manag 2009, 5:909-920.
52. Ip M.S., Tse H.F., Lam B., Tsang K.W., Lam W.K. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 2004, 169:348-353.
53. Bayram N.A., Ciftci B., Keles T., Durmaz T., Turhan S., Bozkurt E., et al. Endothelial function in normotensive men with obstructive sleep apnea before and 6 months after CPAP treatment. Sleep 2009, 32:1257-1263.
54. Chung S., Yoon I.Y., Lee C.H., Kim J.W. The association of nocturnal hypoxemia with arterial stiffness and endothelial dysfunction in male patients with obstructive sleep apnea syndrome. Respiration 2010, 79:363-369.
55. Chung S., Yoon I.Y., Shin Y.K., Lee C.H., Kim J.W., Ahn H.J. Endothelial dysfunction and inflammatory reactions of elderly and middle-aged men with obstructive sleep apnea syndrome. Sleep Breath 2009, 13:11-17.
56. Kato M., Roberts-Thomson P., Phillips B.G., Haynes W.G., Winnicki M., Accurso V., et al. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 2000, 102:2607-2610.
57. de la Pena M., Barcelo A., Barbe F., Pierola J., Pons J., Rimbau E., et al. Endothelial function and circulating endothelial progenitor cells in patients with sleep apnea syndrome. Respiration 2008, 76:28-32.
58. Bagai K., Muldowney J.A., Song Y., Wang L., Bagai J., Artibee K.J., et al. Circadian variability of fibrinolytic markers and endothelial function in patients with obstructive sleep apnea. Sleep 2014, 37:359-367.
59. Yim-Yeh S., Rahangdale S., Nguyen A.T., Jordan A.S., Novack V., Veves A., et al. Obstructive sleep apnea and aging effects on macrovascular and microcirculatory function. Sleep 2010, 33:1177-1183.
60. Yim-Yeh S., Rahangdale S., Nguyen A.T., Stevenson K.E., Novack V., Veves A., et al. Vascular dysfunction in obstructive sleep apnea and type 2 diabetes mellitus. Obesity 2011, 19:17-22.
61. Vgontzas A.N., Papanicolaou D.A., Bixler E.O., Hopper K., Lotsikas A., Lin H.M., et al. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. JClin Endocrinol Metab 2000, 85:1151-1158.
62. Kuk J.L., Katzmarzyk P.T., Nichaman M.Z., Church T.S., Blair S.N., Ross R. Visceral fat is an independent predictor of all-cause mortality in men. Obesity 2006, 14:336-341.
63. Fujimoto W.Y., Bergstrom R.W., Boyko E.J., Chen K.W., Leonetti D.L., Newell-Morris L., et al. Visceral adiposity and incident coronary heart disease in Japanese-American men. The 10-year follow-up results of the Seattle Japanese-American Community diabetes study. Diabetes Care 1999, 22:1808-1812.
64. Carr D.B., Utzschneider K.M., Hull R.L., Kodama K., Retzlaff B.M., Brunzell J.D., et al. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes 2004, 53:2087-2094.
65. Gozal D., Kheirandish-Gozal L., Serpero L.D., Sans Capdevila O., Dayyat E. Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy. Circulation 2007, 116:2307-2314.
66. Brunetti L., Francavilla R., Scicchitano P., Tranchino V., Loscialpo M., Gesualdo M., et al. Impact of sleep respiratory disorders on endothelial function in children. ScientificWorldJournal 2013, 2013:719456.
67. Butt M., Khair O.A., Dwivedi G., Shantsila A., Shantsila E., Lip G.Y. Myocardial perfusion by myocardial contrast echocardiography and endothelial dysfunction in obstructive sleep apnea. Hypertension 2011, 58:417-424.
68. Duchna H.W., Guilleminault C., Stoohs R.A., Faul J.L., Moreno H., Hoffman B.B., et al. Vascular reactivity in obstructive sleep apnea syndrome. Am J Respir Crit Care Med 2000, 161:187-191.
69. Duchna H.W., Orth M., Schultze-Werninghaus G., Guilleminault C., Stoohs R.A. Long-term effects of nasal continuous positive airway pressure on vasodilatory endothelial function in obstructive sleep apnea syndrome. Sleep Breath 2005, 9:97-103.
70. Duchna H.W., Stoohs R., Guilleminault C., Christine Anspach M., Schultze-Werninghaus G., Orth M. Vascular endothelial dysfunction in patients with mild obstructive sleep apnea syndrome. Wien Med Wochenschr 2006, 156:596-604.
71. Jelic S., Padeletti M., Kawut S.M., Higgins C., Canfield S.M., Onat D., et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation 2008, 117:2270-2278.
72. Jelic S., Lederer D.J., Adams T., Padeletti M., Colombo P.C., Factor P.H., et al. Vascular inflammation in obesity and sleep apnea. Circulation 2010, 121:1014-1021.
73. Lattimore J.L., Wilcox I., Skilton M., Langenfeld M., Celermajer D.S. Treatment of obstructive sleep apnoea leads to improved microvascular endothelial function in the systemic circulation. Thorax 2006, 61:491-495.
74. Patt B.T., Jarjoura D., Haddad D.N., Sen C.K., Roy S., Flavahan N.A., et al. Endothelial dysfunction in the microcirculation of patients with obstructive sleep apnea. Am J Respir Crit Care Med 2010, 182:1540-1545.
75. Panoutsopoulos A., Kallianos A., Kostopoulos K., Seretis C., Koufogiorga E., Protogerou A., et al. Effect of CPAP treatment on endothelial function and plasma CRP levels in patients with sleep apnea. Med Sci Monit 2012, 18:CR747-CR751.
76. Kohler M., Craig S., Pepperell J.C., Nicoll D., Bratton D.J., Nunn A.J., et al. CPAP improves endothelial function in patients with minimally symptomatic OSA: results from a subset study of the MOSAIC trial. Chest 2013, 144:896-902.
77. Nguyen P.K., Katikireddy C.K., McConnell M.V., Kushida C., Yang P.C. Nasal continuous positive airway pressure improves myocardial perfusion reserve and endothelial-dependent vasodilation in patients with obstructive sleep apnea. JCardiovasc Magn Reson 2010, 12:50.
78. Comondore V.R., Cheema R., Fox J., Butt A., John Mancini G.B., Fleetham J.A., et al. The impact of CPAP on cardiovascular biomarkers in minimally symptomatic patients with obstructive sleep apnea: a pilot feasibility randomized crossover trial. Lung 2009, 187:17-22.
79. Kohler M., Stoewhas A.C., Ayers L., Senn O., Bloch K.E., Russi E.W., et al. Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med 2011, 184:1192-1199.
80. Westhoff T.H., Schmidt S., Vallbracht-Israng K., Yildirim H., Franke N., Dimeo F., et al. Small artery elasticity assessed by pulse wave analysis is no measure of endothelial dysfunction. JHypertens 2007, 25:571-576.
81. Cross M.D., Mills N.L., Al-Abri M., Riha R., Vennelle M., Mackay T.W., et al. Continuous positive airway pressure improves vascular function in obstructive sleep apnoea/hypopnoea syndrome: a randomised controlled trial. Thorax 2008, 63:578-583.
82. Buchner N.J., Quack I., Woznowski M., Stahle C., Wenzel U., Rump L.C. Microvascular endothelial dysfunction in obstructive sleep apnea is caused by oxidative stress and improved by continuous positive airway pressure therapy. Respiration 2011, 82:409-417.
83. Trzepizur W., Gagnadoux F., Abraham P., Rousseau P., Meslier N., Saumet J.L., et al. Microvascular endothelial function in obstructive sleep apnea: impact of continuous positive airway pressure and mandibular advancement. Sleep Med 2009, 10(7):746-752.
84. Jurado-Gamez B., Fernandez-Marin M.C., Gomez-Chaparro J.L., Munoz-Cabrera L., Lopez-Barea J., Perez-Jimenez F., et al. Relationship of oxidative stress and endothelial dysfunction in sleep apnoea. Eur Respir J 2011, 37:873-879.
85. Itzhaki S., Lavie L., Pillar G., Tal G., Lavie P. Endothelial dysfunction in obstructive sleep apnea measured by peripheral arterial tone response in the finger to reactive hyperemia. Sleep 2005, 28:594-600.
86. Seif F., Patel S.R., Walia H., Rueschman M., Bhatt D.L., Gottlieb D.J., et al. Association between obstructive sleep apnea severity and endothelial dysfunction in an increased background of cardiovascular burden. JSleep Res 2013, 22:443-451.
87. Kraiczi H., Hedner J., Peker Y., Carlson J. Increased vasoconstrictor sensitivity in obstructive sleep apnea. JAppl Physiol 2000, 89:493-498.
88. Carlson J.T., Rangemark C., Hedner J.A. Attenuated endothelium-dependent vascular relaxation in patients with sleep apnoea. JHypertens 1996, 14:577-584.
89. Lavie L., Lavie P. Coronary collateral circulation in sleep apnea: a cardioprotective mechanism?. Chest 2010, 137:511-512.
90. Imadojemu V.A., Gleeson K., Quraishi S.A., Kunselman A.R., Sinoway L.I., Leuenberger U.A. Impaired vasodilator responses in obstructive sleep apnea are improved with continuous positive airway pressure therapy. Am J Respir Crit Care Med 2002, 165:950-953.
91. Oyama J., Yamamoto H., Maeda T., Ito A., Node K., Makino N. Continuous positive airway pressure therapy improves vascular dysfunction and decreases oxidative stress in patients with the metabolic syndrome and obstructive sleep apnea syndrome. Clin Cardiol 2012, 35:231-236.
92. Bakker J.P., Balachandran J.S., Tecilazich F., Deyoung P.N., Smales E., Veves A., et al. Pilot study of the effects of bariatric surgery and continuous positive airway pressure treatment on vascular function in obese subjects with obstructive sleep apnoea. Intern Med J 2013, 43:993-998.
93. Shiina K., Tomiyama H., Takata Y., Yoshida M., Kato K., Saruhara H., et al. Effects of CPAP therapy on the sympathovagal balance and arterial stiffness in obstructive sleep apnea. Respir Med 2010, 104:911-916.
94. Simpson P.J., Hoyos C.M., Celermajer D., Liu P.Y., Ng M.K. Effects of continuous positive airway pressure on endothelial function and circulating progenitor cells in obstructive sleep apnoea: a randomised sham-controlled study. Int J Cardiol 2013, 168:2042-2048.
95. Shinohara E., Kihara S., Yamashita S., Yamane M., Nishida M., Arai T., et al. Visceral fat accumulation as an important risk factor for obstructive sleep apnoea syndrome in obese subjects. JIntern Med 1997, 241:11-18.
96. Kritikou I., Basta M., Tappouni R., Pejovic S., Fernandez-Mendoza J., Nazir R., et al. Sleep apnoea and visceral adiposity in middle-aged male and female subjects. Eur Respir J 2013, 41:601-609.
97. Larsson B., Svardsudd K., Welin L., Wilhelmsen L., Bjorntorp P., Tibblin G. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Br Med J Clin Res Ed 1984, 288:1401-1404.
98. Britton K.A., Massaro J.M., Murabito J.M., Kreger B.E., Hoffmann U., Fox C.S. Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality. JAm Coll Cardiol 2013, 62:921-925.
99. Romero-Corral A., Sert-Kuniyoshi F.H., Sierra-Johnson J., Orban M., Gami A., Davison D., et al. Modest visceral fat gain causes endothelial dysfunction in healthy humans. JAm Coll Cardiol 2010, 56:662-666.
100. Hashimoto M., Akishita M., Eto M., Kozaki K., Ako J., Sugimoto N., et al. The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. Int J Obes Relat Metab Disord 1998, 22:477-484.
101. Sturm W., Sandhofer A., Engl J., Laimer M., Molnar C., Kaser S., et al. Influence of visceral obesity and liver fat on vascular structure and function in obese subjects. Obes (Silver Spring) 2009, 17:1783-1788.
102. Blomster H., Laitinen T., Lyyra-Laitinen T., Vanninen E., Gylling H., Peltonen M., et al. Endothelial function is well preserved in obese patients with mild obstructive sleep apnea. Sleep Breath 2014, 18:177-186.
103. Bruno R.M., Rossi L., Fabbrini M., Duranti E., Di Coscio E., Maestri M., et al. Renal vasodilating capacity and endothelial function are impaired in patients with obstructive sleep apnea syndrome and no traditional cardiovascular risk factors. JHypertens 2013, 31:1456-1464.
104. Cassar A., Morgenthaler T.I., Rihal C.S., Prasad A., Lennon R.J., Lerman L.O., et al. Coronary endothelial function in patients with obstructive sleep apnea. Coron Artery Dis 2014, 25:16-22.
105. Chung S., Yoon I.Y., Shin Y.K., Lee C.H., Kim J.W., Lee T., et al. Endothelial dysfunction and C-reactive protein in relation with the severity of obstructive sleep apnea syndrome. Sleep 2007, 30:997-1001.
106. Del Ben M., Fabiani M., Loffredo L., Polimeni L., Carnevale R., Baratta F., et al. Oxidative stress mediated arterial dysfunction in patients with obstructive sleep apnoea and the effect of continuous positive airway pressure treatment. BMC Pulm Med 2012, 12:36.
107. El Solh A.A., Akinnusi M.E., Baddoura F.H., Mankowski C.R. Endothelial cell apoptosis in obstructive sleep apnea: a link to endothelial dysfunction. Am J Respir Crit Care Med 2007, 175:1186-1191.
108. Jones A., Vennelle M., Connell M., McKillop G., Newby D.E., Douglas N.J., et al. Arterial stiffness and endothelial function in obstructive sleep apnoea/hypopnoea syndrome. Sleep Med 2013, 14:428-432.
109. Kohler M., Craig S., Nicoll D., Leeson P., Davies R.J., Stradling J.R. Endothelial function and arterial stiffness in minimally symptomatic obstructive sleep apnea. Am J Respir Crit Care Med 2008, 178:984-988.
110. Oflaz H., Cuhadaroglu C., Pamukcu B., Meric M., Ece T., Kasikcioglu E., et al. Endothelial function in patients with obstructive sleep apnea syndrome but without hypertension. Respiration 2006, 73:751-756.
111. Tan H.L., Gozal D., Samiei A., Bhattacharjee R., Wang Y., Ramirez H.M., et al. Tregulatory lymphocytes and endothelial function in pediatric obstructive sleep apnea. PLoS One 2013, 8:e69710.
112. Cereda C.W., Tamisier R., Manconi M., Andreotti J., Frangi J., Pifferini V., et al. Endothelial dysfunction and arterial stiffness in ischemic stroke: the role of sleep-disordered breathing. Stroke 2013, 44:1175-1178.
113. Kheirandish-Gozal L., Bhattacharjee R., Kim J., Clair H.B., Gozal D. Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apnea. Am J Respir Crit Care Med 2010, 182:92-97.
114. Ohike Y., Kozaki K., Iijima K., Eto M., Kojima T., Ohga E., et al. Amelioration of vascular endothelial dysfunction in obstructive sleep apnea syndrome by nasal continuous positive airway pressure-possible involvement of nitric oxide and asymmetric NG, NG-dimethylarginine. Circ J 2005, 69:221-226.
115. Tulmac M., Tireli E., Ebinc H., Simsek V., Dogru M.T., Yildirim N., et al. Effect of overnight nasal continuous positive airway pressure treatment on the endothelial function in patients with obstructive sleep apnea. Anadolu Kardiyol Derg Anatol J Cardiol 2012, 12:560-565.
116. Jones A., Vennelle M., Connell M., McKillop G., Newby D.E., Douglas N.J., et al. The effect of continuous positive airway pressure therapy on arterial stiffness and endothelial function in obstructive sleep apnea: a randomized controlled trial in patients without cardiovascular disease. Sleep Med 2013, 14:1260-1265.