Elevated levels of endothelial cell-derived microparticles following short-term withdrawal of continuous positive airway pressure in patients with obstructive sleep apnea: Data from a randomized controlled trial

Respiration

Volumn 85, Issue 6, 2013, Pages 478-485

  Ayers, Lisa ^a   Stoewhas, Anne Christin ^b   Ferry, Berne ^a   Stradling, John ^a   Kohler, Malcolm ^b,c  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cell derived microparticles; Continuous positive airway pressure; Endothelial dysfunction; Obstructive sleep apnea

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GRANULOCYTE; HUMAN; LEUKOCYTE MICROPARTICLE; MALE; PLATELET MICROPARTICLE; POLYSOMNOGRAPHY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SHORT COURSE THERAPY; SLEEP DISORDERED BREATHING; TREATMENT DURATION; TREATMENT WITHDRAWAL; ENDOTHELIAL MICROPARTICLE; LEUKOCYTE; OUTCOME ASSESSMENT;

AGED; BLOOD CELLS; CELL-DERIVED MICROPARTICLES; CONTINUOUS POSITIVE AIRWAY PRESSURE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SLEEP APNEA, OBSTRUCTIVE; WITHHOLDING TREATMENT;

EID: 84878508814     PISSN: 00257931     EISSN: 14230356     Source Type: Journal    
DOI: 10.1159/000342877     Document Type: Article

References (29)

1. Young T, Peppard PE, Gottlieb DJ: Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002; 165: 1217-1239.
2. Patil SP, Schneider H, Schwartz AR, Smith PL: Adult obstructive sleep apnea: pathophysiology and diagnosis. Chest 2007; 132: 325-337.
3. Peker Y, Hedner J, Norum J, Kraiczi H, Carlson J: Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: a 7-year follow-up. Am J Respir Crit Care Med 2002; 166: 159-165.
4. Peppard PE, Young T, Palta M, Skatrud J: Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000; 342: 1378-1384.
5. Marin JM, Carrizo SJ, Vicente E, Agusti AG: Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005; 365: 1046-1053.
6. Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O'Connor GT, Resnick HE, Diener-West M, Sanders MH, Wolf PA, Geraghty EM, Ali T, Lebowitz M, Punjabi NM: Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med 2010; 182: 269-277.
7. Kohler M, Stradling JR: Mechanisms of vascular damage in obstructive sleep apnea. Nat Rev Cardiol 2010; 7: 677-685.
8. Ip MS, Tse HF, Lam B, Tsang KW, Lam WK: Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 2004; 169: 348-353.
9. Cross MD, Mills NL, Al-Abri M, Riha R, Vennelle M, Mackay TW, Newby DE, Douglas NJ: Continuous positive airway pressure improves vascular function in obstructive sleep apnoea/hypopnoea syndrome: a randomised controlled trial. Thorax 2008; 63: 578-583.
10. Buchner NJ, Quack I, Woznowski M, Stahle C, Wenzel U, Rump LC: Microvascular endothelial dysfunction in obstructive sleep apnea is caused by oxidative stress and improved by continuous positive airway pressure therapy. Respiration 2011; 82: 409-417.
11. Galetke W, Puzzo L, Priegnitz C, Anduleit N, Randerath WJ: Long-term therapy with continuous positive airway pressure in obstructive sleep apnea: adherence, side effects and predictors of withdrawal-a 'real-life' study. Respiration 2011; 82: 155-161.
12. VanWijk MJ, VanBavel E, Sturk A, Nieuwland R: Microparticles in cardiovascular diseases. Cardiovasc Res 2003; 59: 277-287.
13. Chironi G, Simon A, Hugel B, Del Pino M, Gariepy J, Freyssinet JM, Tedgui A: Circulating leukocyte-derived microparticles predict subclinical atherosclerosis burden in asymptomatic subjects. Arterioscler Thromb Vasc Biol 2006; 26: 2775-2780.
14. Ayers L, Ferry B, Craig S, Nicoll D, Stradling JR, Kohler M: Circulating cell-derived microparticles in patients with minimally symptomatic obstructive sleep apnoea. Eur Respir J 2009; 33: 574-580.
15. Jelic S, Lederer DJ, Adams T, Padeletti M, Colombo PC, Factor P, Le Jemtel TH: Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea. Vasc Health Risk Manag 2009; 5: 909-920.
16. Yun CH, Jung KH, Chu K, Kim SH, Ji KH, Park HK, Kim HC, Lee ST, Lee SK, Roh JK: Increased circulating endothelial microparticles and carotid atherosclerosis in obstructive sleep apnea. J Clin Neurol 2010; 6: 89-98.
17. Kim J, Bhattacharjee R, Kheirandish-Gozal L, Spruyt K, Gozal D: Circulating microparticles in children with sleep disordered breathing. Chest 2011; 140: 408-417.
18. Kohler M, Stoewhas AC, Ayers L, Senn O, Bloch KE, Russi EW, Stradling JR: The effects of CPAP therapy withdrawal in patients with obstructive sleep apnea: a randomised controlled trial. Am J Respir Crit Care Med 2011; 184: 1192-1199.
19. Pepperell JC, Ramdassingh-Dow S, Crosthwaite N, Mullins R, Jenkinson C, Stradling JR, Davies RJ: Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial. Lancet 2002; 359: 204-210.
20. Johns MW: A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991; 14: 540-545.
21. Haentjens P, Van Meerhaeghe A, Moscariello A, De Weerdt S, Poppe K, Dupont A, Velkeniers B: The impact of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea syndrome: evidence from a meta-analysis of placebo-controlled randomized trials. Arch Intern Med 2007; 167: 757-764.
22. Amabile N, Guerin AP, Leroyer A, Mallat Z, Nguyen C, Boddaert J, London GM, Tedgui A, Boulanger CM: Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure. J Am Soc Nephrol 2005; 16: 3381-3388.
23. Gozal D, Kheirandish-Gozal L: Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more. Am J Respir Crit Care Med 2008; 177: 369-375.
24. Budhiraja R, Parthasarathy S, Quan SF: Endothelial dysfunction in obstructive sleep apnea. J Clin Sleep Med 2007; 3: 409-415.
25. Amabile N, Heiss C, Real WM, Minasi P, Mc-Glothlin D, Rame EJ, Grossman W, De Marco T, Yeghiazarians Y: Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension. Am J Respir Crit Care Med 2008; 177: 1268-1275.
26. Priou P, Gagnadoux F, Tesse A, Mastronardi ML, Agouni A, Meslier N, Racineux JL, Martinez MC, Trzepizur W, Andriantsitohaina R: Endothelial dysfunction and circulating microparticles from patients with obstructive sleep apnea. Am J Pathol 2010; 177: 974-983.
27. Schulz R, Mahmoudi S, Hattar K, Sibelius U, Olschewski H, Mayer K, Seeger W, Grimminger F: Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea: impact of continuous positive airway pressure therapy. Am J Respir Crit Care Med 2000; 162: 566-570.
28. Ardoin SP, Shanahan JC, Pisetsky DS: The role of microparticles in inflammation and thrombosis. Scand J Immunol 2007; 66: 159-165.
29. Beyer C, Pisetsky DS: The role of microparticles in the pathogenesis of rheumatic diseases. Nat Rev Rheumatol 2010; 6: 21-29.