Endothelial dysfunction and inflammatory reactions of elderly and middle-aged men with obstructive sleep apnea syndrome

Sleep and Breathing

Volumn 13, Issue 1, 2009, Pages 11-17

  Chung, Seockhoon ^a   Yoon, In Young ^a   Shin, Yoon Kyung ^a   Lee, Chul Hee ^a   Kim, Jeong Whun ^a   Ahn, Hee Jeong ^a  

^a Seoul National University Bundang Hospital   (South Korea)

Author keywords

C reactive protein; Elderly; Flow mediated dilatation; Obstructive sleep apnea syndrome

Indexed keywords

ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; C REACTIVE PROTEIN;

ADULT; AGED; ANTHROPOMETRIC PARAMETERS; ARTERY BLOOD FLOW; ARTICLE; ATHEROSCLEROSIS; BLOOD OXYGEN TENSION; BLOOD SAMPLING; BODY MASS; BRACHIAL ARTERY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; HYPOXEMIA; HYPOXIA; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; OBESITY; POLYSOMNOGRAPHY; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RESPIRATORY TRACT DISEASE; RISK ASSESSMENT; SLEEP APNEA SYNDROME; VASCULAR ENDOTHELIUM; VASODILATATION; WAIST HIP RATIO;

ADULT; AGED; BODY MASS INDEX; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; HUMANS; MALE; MIDDLE AGED; OBESITY; POLYSOMNOGRAPHY; PREVALENCE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SLEEP APNEA, OBSTRUCTIVE;

EID: 58149186701     PISSN: 15209512     EISSN: 15221709     Source Type: Journal    
DOI: 10.1007/s11325-008-0210-x     Document Type: Article

References (38)

1. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230-1235 doi: 10.1056/NEJM199304293281704
2. Hader C, Schroeder A, Hinz M, Micklefield GH, Rasche K (2005) Sleep disordered breathing in the elderly: Comparison of women and men. J Physiol Pharmacol 56(Suppl 4):85-91
3. Redline S (1998) Epidemiology of sleep-disordered breathing. Semin Respir Crit Care Med 19:113-122
4. Bixler EO, Vgontzas AN, Ten Have T, Tyson K, Kales A (1998) Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med 157:144-148
5. Ancoli-Israel S, Kripke DF, Klauber MR, Mason WJ, Fell R, Kaplan O (1991) Sleep-disordered breathing in community-dwelling elderly. Sleep 14:486-495
6. Shamsuzzaman AS, Gersh BJ, Somers VK (2003) Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA 290:1906-1914 doi: 10.1001/jama.290.14.1906
7. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V (2005) Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 353:2034-2041 doi: 10.1056/NEJMoa043104
8. Ancoli-Israel S, Kripke DF, Klauber MR, Fell R, Stepnowsky C, Estline E et al (1996) Morbidity, mortality and sleep-disordered breathing in community dwelling elderly. Sleep 19:277-282
9. Strandberg TE, Tilvis RS (2000) C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderly. Arterioscler Thromb Vasc Biol 20:1057-1060
10. Lattimore JL, Wilcox I, Skilton M, Langenfeld M, Celermajer DS (2006) Treatment of obstructive sleep apnoea leads to improved microvascular endothelial function in the systemic circulation. Thorax 61:491-495 doi: 10.1136/thx.2004.039164
11. Imadojemu VA, Gleeson K, Quraishi SA, Kunselman AR, Sinoway LI, Leuenberger UA (2002) Impaired vasodilator responses in obstructive sleep apnea are improved with continuous positive airway pressure therapy. Am J Respir Crit Care Med 165:950-953
12. Ip MS, Tse HF, Lam B, Tsang KW, Lam WK (2004) Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 169:348-353 doi: 10.1164/rccm.200306-767OC
13. Haverkate F, Thompson SG, Pyke SD, Gallimore JR, Pepys MB (1997) Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Lancet 349:462-466 doi: 10.1016/S0140-6736(96)07591-5
14. Guilleminault C, Kirisoglu C, Ohayon MM (2004) C-reactive protein and sleep-disordered breathing. Sleep 27:1507-1511
15. Shamsuzzaman AS, Winnicki M, Lanfranchi P, Wolk R, Kara T, Accurso V et al (2002) Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 105:2462-2464 doi: 10.1161/01.CIR.0000018948.95175.03
16. Chung S, Yoon IY, Shin YK, Lee CH, Kim JW, Lee T et al (2007) Endothelial dysfunction and C-reactive protein in relation with the severity of obstructive sleep apnea syndrome. Sleep 30:997-1001
17. Faulx MD, Wright AT, Hoit BD (2003) Detection of endothelial dysfunction with brachial artery ultrasound scanning. Am Heart J 145:943-951 doi: 10.1016/S0002-8703(03)00097-8
18. Rechtschaffen A, Kales A (1968) A manual of standardized terminology, technique, and scoring system for sleep stages of human subjects. Brain Information Service/Brain Research Institute, UCLA, Los Angeles
19. Gould GA, Whyte KF, Rhind GB, Airlie MA, Catterall JR, Shapiro CM et al (1988) The sleep hypopnea syndrome. Am Rev Respir Dis 137:895-898
20. Tatsumi K, Kasahara Y, Kurosu K, Tanabe N, Takiguchi Y, Kuriyama T (2005) Sleep oxygen desaturation and circulating leptin in obstructive sleep apnea-hypopnea syndrome. Chest 127:716-721 doi: 10.1378/ chest.127.3.716
21. Christou K, Kostikas K, Pastaka C, Tanou K, Antoniadou I, Gourgoulianis KI (2007) Nasal continuous positive airway pressure treatment reduces systemic oxidative stress in patients with severe obstructive sleep apnea syndrome. Sleep Med (in press)
22. Kraiczi H, Caidahl K, Samuelsson A, Peker Y, Hedner J (2001) Impairment of vascular endothelial function and left ventricular filling: association with the severity of apnea-induced hypoxemia during sleep. Chest 119:1085-1091 doi: 10.1378/chest.119.4.1085
23. Teramoto S, Kume H, Matsuse T, Ishii T, Miyashita A, Akishita M et al (2003) Oxygen administration improves the serum level of nitric oxide metabolites in patients with obstructive sleep apnea syndrome. Sleep Med 4:403-407 doi: 10.1016/S1389-9457(03)00102-3
24. Leeman M, de Beyl VZ, Biarent D, Maggiorini M, Melot C, Naeije R (1999) Inhibition of cyclooxygenase and nitric oxide synthase in hypoxic vasoconstriction and oleic acid-induced lung injury. Am J Respir Crit Care Med 159:1383-1390
25. Saletu M, Nosiska D, Kapfhammer G, Lalouschek W, Saletu B, Benesch T et al (2006) Structural and serum surrogate markers of cerebrovascular disease in obstructive sleep apnea (OSA): Association of mild OSA with early atherosclerosis. J Neurol 253:746-752 doi: 10.1007/ s00415-006-0110-6
26. Lavie L (2003) Obstructive sleep apnoea syndrome-an oxidative stress disorder. Sleep Med Rev 7:35-51 doi: 10.1053/smrv.2002.0261
27. Nieto FJ, Herrington DM, Redline S, Benjamin EJ, Robbins JA (2004) Sleep apnea and markers of vascular endothelial function in a large community sample of older adults. Am J Respir Crit Care Med 169:354-360 doi: 10.1164/rccm.200306-756OC
28. Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A et al (2001) Age-related reduction of NO availability and oxidative stress in humans. Hypertension 38:274-279
29. Cosentino F, Osto E (2007) Aging and endothelial dysfunction. Clin Hemorheol Microcirc 37:143-147
30. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH (2000) Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101:1767-1772
31. Yokoe T, Minoguchi K, Matsuo H, Oda N, Minoguchi H, Yoshino G et al (2003) Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure. Circulation 107:1129-1134 doi: 10.1161/01.CIR.0000052627.99976.18
32. Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P et al (2005) Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: A case-control study. Lancet 366:1640-1649 doi: 10.1016/S0140-6736(05)67663-5
33. Young T, Rabago D, Zgierska A, Austin D, Laurel F (2003) Objective and subjective sleep quality in premenopausal, perimenopausal, and postmenopausal women in the Wisconsin Sleep Cohort Study. Sleep 26:667-672
34. Jensen-Urstad K, Johansson J (2001) Gender difference in age-related changes in vascular function. J Intern Med 250:29-36 doi: 10.1046/ j.1365-2796.2001.00843.x
35. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S (1994) Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA 91:5212-5216 doi: 10.1073/ pnas.91.11.5212
36. Badeau M, Adlercreutz H, Kaihovaara P, Tikkanen MJ (2005) Estrogen A-ring structure and antioxidative effect on lipoproteins. J Steroid Biochem Mol Biol 96:271-278 doi: 10.1016/j.jsbmb.2005.04.034
37. Taddei S, Virdis A, Ghiadoni L, Sudano I, Salvetti A (2000) Antihypertensive drugs and reversing of endothelial dysfunction in hypertension. Curr Hypertens Rep 2:64-70 doi: 10.1007/s11906-000-0061-8
38. Martens FM, Visseren FL, de Koning EJ, Rabelink TJ (2005) Short-term pioglitazone treatment improves vascular function irrespective of metabolic changes in patients with type 2 diabetes. J Cardiovasc Pharmacol 46:773-778 doi: 10.1097/01.fjc.0000187176.13403.05