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Volumn 14, Issue 1, 2015, Pages

Folate, Vitamin B12 and Homocysteine status in the post-folic acid fortification era in different subgroups of the Brazilian population attended to at a public health care center

Author keywords

Folate; Folic acid fortification; Glutamate carboxypeptidase II; Homocysteine; Methylenetetrahydrofolate reductase; Reduced folate carrier; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; CARBOXYPEPTIDASE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN; REDUCED FOLATE CARRIER; SLC19A1 PROTEIN, HUMAN;

EID: 84924964560     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/s12937-015-0006-3     Document Type: Article
Times cited : (45)

References (62)
  • 1
    • 0034014432 scopus 로고    scopus 로고
    • Folic acid: Influence on the outcome of pregnancy
    • 1:CAS:528:DC%2BD3cXivFymur8%3D
    • Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr. 2000;71:1295S-303.
    • (2000) Am J Clin Nutr , vol.71 , pp. 1295S-303
    • Scholl, T.O.1    Johnson, W.G.2
  • 2
    • 48249129119 scopus 로고    scopus 로고
    • Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies
    • de Benoist B. Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food Nutr Bull. 2008;29:S238-44.
    • (2008) Food Nutr Bull , vol.29 , pp. 238-244
    • De Benoist, B.1
  • 3
    • 0037164375 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis
    • Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002;325:1202.
    • (2002) BMJ , vol.325 , pp. 1202
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 4
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • Homocysteine Studies Collaboration 10.1001/jama.288.16.2015
    • Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. Jama. 2002;288:2015-22.
    • (2002) Jama , vol.288 , pp. 2015-2022
  • 5
    • 48249125816 scopus 로고    scopus 로고
    • Causes of vitamin B12 and folate deficiency
    • discussion S35-27
    • Allen LH. Causes of vitamin B12 and folate deficiency. Food Nutr Bull. 2008;29:S20-34. discussion S35-27.
    • (2008) Food Nutr Bull , vol.29 , pp. 20-34
    • Allen, L.H.1
  • 6
    • 0034703861 scopus 로고    scopus 로고
    • Glutamate carboxypeptidase II: A polymorphism associated with lower levels of serum folate and hyperhomocysteinemia
    • 1:CAS:528:DC%2BD3cXoslWmsLw%3D
    • Devlin AM, Ling EH, Peerson JM, Fernando S, Clarke R, Smith AD, et al. Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. Hum Mol Genet. 2000;9:2837-44.
    • (2000) Hum Mol Genet , vol.9 , pp. 2837-2844
    • Devlin, A.M.1    Ling, E.H.2    Peerson, J.M.3    Fernando, S.4    Clarke, R.5    Smith, A.D.6
  • 7
    • 0036276029 scopus 로고    scopus 로고
    • The glutamate carboxypeptidase gene II (C > T) polymorphism does not affect folate status in the Framingham Offspring cohort
    • 1:CAS:528:DC%2BD38XksFWnsLY%3D
    • Vargas-Martinez C, Ordovas JM, Wilson PW, Selhub J. The glutamate carboxypeptidase gene II (C > T) polymorphism does not affect folate status in the Framingham Offspring cohort. J Nutr. 2002;132:1176-9.
    • (2002) J Nutr , vol.132 , pp. 1176-1179
    • Vargas-Martinez, C.1    Ordovas, J.M.2    Wilson, P.W.3    Selhub, J.4
  • 8
    • 0032497941 scopus 로고    scopus 로고
    • Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: The result of a meta-analysis
    • 1:CAS:528:DyaK1MXlvVeh
    • Brattstrom L, Wilcken DE, Ohrvik J, Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation. 1998;98:2520-6.
    • (1998) Circulation , vol.98 , pp. 2520-2526
    • Brattstrom, L.1    Wilcken, D.E.2    Ohrvik, J.3    Brudin, L.4
  • 9
    • 0034168107 scopus 로고    scopus 로고
    • The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events
    • D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, et al. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost. 2000;83:563-70.
    • (2000) Thromb Haemost , vol.83 , pp. 563-570
    • D'Angelo, A.1    Coppola, A.2    Madonna, P.3    Fermo, I.4    Pagano, A.5    Mazzola, G.6
  • 10
    • 36248993031 scopus 로고    scopus 로고
    • Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults
    • 1:CAS:528:DC%2BD2sXhtlWmsL7I
    • Hoey L, McNulty H, Askin N, Dunne A, Ward M, Pentieva K, et al. Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults. Am J Clin Nutr. 2007;86:1405-13.
    • (2007) Am J Clin Nutr , vol.86 , pp. 1405-1413
    • Hoey, L.1    McNulty, H.2    Askin, N.3    Dunne, A.4    Ward, M.5    Pentieva, K.6
  • 11
    • 80053201724 scopus 로고    scopus 로고
    • Vitamin B12 and homocysteine status in a folate-replete population: Results from the Canadian Health Measures Survey
    • 1:CAS:528:DC%2BC3MXht1OgurrF
    • MacFarlane AJ, Greene-Finestone LS, Shi Y. Vitamin B12 and homocysteine status in a folate-replete population: results from the Canadian Health Measures Survey. Am J Clin Nutr. 2011;94:1079-87.
    • (2011) Am J Clin Nutr , vol.94 , pp. 1079-1087
    • Macfarlane, A.J.1    Greene-Finestone, L.S.2    Shi, Y.3
  • 12
    • 84924998855 scopus 로고    scopus 로고
    • Ministério da Saúde, Agência Nacional de Vigilância Sanitária do Brasil (ANVISA) Accessed 18 Jun 2013
    • Ministério da Saúde, Agência Nacional de Vigilância Sanitária do Brasil (ANVISA). In: Resolução RDC n°344. 2002. http://portal.anvisa.gov.br/wps/wcm/connect/f851a500474580668c83dc3fbc4c6735/RDC-344-2002.pdf?MOD=AJPERES. Accessed 18 Jun 2013.
    • (2002) Resolução RDC N° , vol.344
  • 14
    • 82455198804 scopus 로고    scopus 로고
    • Folate recommendations for pregnancy, lactation, and infancy
    • 1:CAS:528:DC%2BC3MXhsFamt7zN
    • Lamers Y. Folate recommendations for pregnancy, lactation, and infancy. Ann Nutr Metab. 2011;59:32-7.
    • (2011) Ann Nutr Metab , vol.59 , pp. 32-37
    • Lamers, Y.1
  • 15
    • 0032992889 scopus 로고    scopus 로고
    • Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting
    • 1:CAS:528:DyaK1MXhtFGltb8%3D
    • Pfeiffer CM, Huff DL, Gunter EW. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin Chem. 1999;45:290-2.
    • (1999) Clin Chem , vol.45 , pp. 290-292
    • Pfeiffer, C.M.1    Huff, D.L.2    Gunter, E.W.3
  • 16
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • 1:CAS:528:DyaK2MXlsVymt78%3D
    • Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111-3.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 17
    • 0033805360 scopus 로고    scopus 로고
    • A polymorphism (80G- > A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia
    • 1:CAS:528:DC%2BD3cXmsFemurc%3D
    • Chango A, Emery-Fillon N, de Courcy GP, Lambert D, Pfister M, Rosenblatt DS, et al. A polymorphism (80G- > A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia. Mol Genet Metab. 2000;70:310-5.
    • (2000) Mol Genet Metab , vol.70 , pp. 310-315
    • Chango, A.1    Emery-Fillon, N.2    De Courcy, G.P.3    Lambert, D.4    Pfister, M.5    Rosenblatt, D.S.6
  • 18
  • 19
    • 33750602084 scopus 로고    scopus 로고
    • World Health Organization, Food and Agricultural Organization WHO/FAO Geneva, Switzerland
    • World Health Organization, Food and Agricultural Organization. Guidelines on food fortification with micronutrients. Geneva, Switzerland: WHO/FAO; 2006.
    • (2006) Guidelines on Food Fortification with Micronutrients
  • 20
  • 21
    • 48249154610 scopus 로고    scopus 로고
    • A high prevalence of biochemical evidence of vitamin B12 or folate deficiency does not translate into a comparable prevalence of anemia
    • Metz J. A high prevalence of biochemical evidence of vitamin B12 or folate deficiency does not translate into a comparable prevalence of anemia. Food Nutr Bull. 2008;29:S74-85.
    • (2008) Food Nutr Bull , vol.29 , pp. 74-85
    • Metz, J.1
  • 22
    • 0001504081 scopus 로고
    • Clinical spectrum and diagnosis of folate deficiency
    • L.B. Bailey (eds) Marcel Dekker, Inc New York
    • Lindenbaum J, Allen RH. Clinical spectrum and diagnosis of folate deficiency. In: Bailey LB, editor. Folate in health and disease. New York: Marcel Dekker, Inc; 1995. p. 43-73.
    • (1995) Folate in Health and Disease , pp. 43-73
    • Lindenbaum, J.1    Allen, R.H.2
  • 26
    • 33745359474 scopus 로고    scopus 로고
    • Clinical relevance of low serum vitamin B12 concentrations in older people: The Banbury B12 study
    • Hin H, Clarke R, Sherliker P, Atoyebi W, Emmens K, Birks J, et al. Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study. Age Ageing. 2006;35:416-22.
    • (2006) Age Ageing , vol.35 , pp. 416-422
    • Hin, H.1    Clarke, R.2    Sherliker, P.3    Atoyebi, W.4    Emmens, K.5    Birks, J.6
  • 27
    • 79959439256 scopus 로고    scopus 로고
    • Biomarkers of cobalamin (vitamin B12) status in the epidemiologic setting: A critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II
    • 1:CAS:528:DC%2BC3MXot1Khurc%3D
    • Carmel R. Biomarkers of cobalamin (vitamin B12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr. 2011;94:348S-58.
    • (2011) Am J Clin Nutr , vol.94 , pp. 348S-58
    • Carmel, R.1
  • 28
    • 46249132127 scopus 로고    scopus 로고
    • Vitamin B12 status is associated with socioeconomic level and adherence to an animal food dietary pattern in Colombian school children
    • 1:CAS:528:DC%2BD1cXnsVOlur4%3D
    • Villamor E, Mora-Plazas M, Forero Y, Lopez-Arana S, Baylin A. Vitamin B12 status is associated with socioeconomic level and adherence to an animal food dietary pattern in Colombian school children. J Nutr. 2008;138:1391-8.
    • (2008) J Nutr , vol.138 , pp. 1391-1398
    • Villamor, E.1    Mora-Plazas, M.2    Forero, Y.3    Lopez-Arana, S.4    Baylin, A.5
  • 29
    • 84860502891 scopus 로고    scopus 로고
    • Underlying factors associated with anemia in Amazonian children: A population-based, cross-sectional study
    • 1:CAS:528:DC%2BC38XnsV2hsbY%3D
    • Cardoso MA, Scopel KK, Muniz PT, Villamor E, Ferreira MU. Underlying factors associated with anemia in Amazonian children: a population-based, cross-sectional study. PLoS ONE. 2012;7:e36341.
    • (2012) PLoS ONE , vol.7 , pp. 36341
    • Cardoso, M.A.1    Scopel, K.K.2    Muniz, P.T.3    Villamor, E.4    Ferreira, M.U.5
  • 30
    • 79952382434 scopus 로고    scopus 로고
    • Cardoso MA: [Complementary feeding and nutritional status of 6-24-month-old children in Acrelandia, Acre State, Western Brazilian Amazon]
    • Garcia MT, Granado FS. Cardoso MA: [Complementary feeding and nutritional status of 6-24-month-old children in Acrelandia, Acre State, Western Brazilian Amazon]. Cad Saude Publica. 2011;27:305-16.
    • (2011) Cad Saude Publica , vol.27 , pp. 305-316
    • Garcia, M.T.1    Granado, F.S.2
  • 31
    • 78049419968 scopus 로고    scopus 로고
    • Folic acid fortification above mandated levels results in a low prevalence of folate inadequacy among Canadians
    • 1:CAS:528:DC%2BC3cXht1GisLrI
    • Shakur YA, Garriguet D, Corey P, O'Connor DL. Folic acid fortification above mandated levels results in a low prevalence of folate inadequacy among Canadians. Am J Clin Nutr. 2010;92:818-25.
    • (2010) Am J Clin Nutr , vol.92 , pp. 818-825
    • Shakur, Y.A.1    Garriguet, D.2    Corey, P.3    O'Connor, D.L.4
  • 34
    • 0036637392 scopus 로고    scopus 로고
    • Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B12
    • 1:CAS:528:DC%2BD38Xltlertb4%3D
    • Guerra-Shinohara EM, Paiva AA, Rondo PH, Yamasaki K, Terzi CA, D'Almeida V. Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B12. Bjog. 2002;109:784-91.
    • (2002) Bjog , vol.109 , pp. 784-791
    • Guerra-Shinohara, E.M.1    Paiva, A.A.2    Rondo, P.H.3    Yamasaki, K.4    Terzi, C.A.5    D'Almeida, V.6
  • 35
    • 0035919139 scopus 로고    scopus 로고
    • Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects
    • 1:CAS:528:DC%2BD3MXltV2ks7s%3D
    • Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LY. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA. 2001;285:2981-6.
    • (2001) JAMA , vol.285 , pp. 2981-2986
    • Honein, M.A.1    Paulozzi, L.J.2    Mathews, T.J.3    Erickson, J.D.4    Wong, L.Y.5
  • 36
    • 0037153743 scopus 로고    scopus 로고
    • Association of neural tube defects and folic acid food fortification in Canada
    • Ray JG, Meier C, Vermeulen MJ, Boss S, Wyatt PR, Cole DE. Association of neural tube defects and folic acid food fortification in Canada. Lancet. 2002;360:2047-8.
    • (2002) Lancet , vol.360 , pp. 2047-2048
    • Ray, J.G.1    Meier, C.2    Vermeulen, M.J.3    Boss, S.4    Wyatt, P.R.5    Cole, D.E.6
  • 37
    • 0242426674 scopus 로고    scopus 로고
    • Latin American Collaborative Study of Congenital M: Preliminary data on changes in neural tube defect prevalence rates after folic acid fortification in South America
    • Castilla EE, Orioli IM, Lopez-Camelo JS, Dutra Mda G, Nazer-Herrera J. Latin American Collaborative Study of Congenital M: Preliminary data on changes in neural tube defect prevalence rates after folic acid fortification in South America. Am J Med Genet A. 2003;123A:123-8.
    • (2003) Am J Med Genet A , vol.123 , pp. 123-128
    • Castilla, E.E.1    Orioli, I.M.2    Lopez-Camelo, J.S.3    Dutra Mda, G.4    Nazer-Herrera, J.5
  • 38
    • 31044452644 scopus 로고    scopus 로고
    • High prevalence of folic acid and vitamin B12 deficiencies in infants, children, adolescents and pregnant women in Venezuela
    • 1:CAS:528:DC%2BD2MXpslaltrY%3D
    • Garcia-Casal MN, Osorio C, Landaeta M, Leets I, Matus P, Fazzino F, et al. High prevalence of folic acid and vitamin B12 deficiencies in infants, children, adolescents and pregnant women in Venezuela. Eur J Clin Nutr. 2005;59:1064-70.
    • (2005) Eur J Clin Nutr , vol.59 , pp. 1064-1070
    • Garcia-Casal, M.N.1    Osorio, C.2    Landaeta, M.3    Leets, I.4    Matus, P.5    Fazzino, F.6
  • 39
    • 44849084799 scopus 로고    scopus 로고
    • High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification
    • 1:STN:280:DC%2BD1czjslSruw%3D%3D
    • Ray JG, Goodman J, O'Mahoney PR, Mamdani MM, Jiang D. High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification. QJM. 2008;101:475-7.
    • (2008) QJM , vol.101 , pp. 475-477
    • Ray, J.G.1    Goodman, J.2    O'Mahoney, P.R.3    Mamdani, M.M.4    Jiang, D.5
  • 40
    • 0344837893 scopus 로고    scopus 로고
    • Vitamin B12 insufficiency and the risk of fetal neural tube defects
    • 1:STN:280:DC%2BD3s3gsVOgsQ%3D%3D
    • Ray JG, Blom HJ. Vitamin B12 insufficiency and the risk of fetal neural tube defects. QJM. 2003;96:289-95.
    • (2003) QJM , vol.96 , pp. 289-295
    • Ray, J.G.1    Blom, H.J.2
  • 41
  • 43
    • 38949107356 scopus 로고    scopus 로고
    • Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study
    • 1:CAS:528:DC%2BD1cXitFajsbc%3D
    • Wallace JM, Bonham MP, Strain J, Duffy EM, Robson PJ, Ward M, et al. Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study. Am J Clin Nutr. 2008;87:391-7.
    • (2008) Am J Clin Nutr , vol.87 , pp. 391-397
    • Wallace, J.M.1    Bonham, M.P.2    Strain, J.3    Duffy, E.M.4    Robson, P.J.5    Ward, M.6
  • 44
    • 0025245794 scopus 로고
    • Vitamin B12: Low milk concentrations are related to low serum concentrations in vegetarian women and to methylmalonic aciduria in their infants
    • 1:CAS:528:DyaK3MXhsVWqtbw%3D
    • Specker BL, Black A, Allen L, Morrow F. Vitamin B12: low milk concentrations are related to low serum concentrations in vegetarian women and to methylmalonic aciduria in their infants. Am J Clin Nutr. 1990;52:1073-6.
    • (1990) Am J Clin Nutr , vol.52 , pp. 1073-1076
    • Specker, B.L.1    Black, A.2    Allen, L.3    Morrow, F.4
  • 45
    • 0030866169 scopus 로고    scopus 로고
    • Vitamin B12 deficiency is very prevalent in lactating Guatemalan women and their infants at three months postpartum
    • 1:CAS:528:DyaK2sXmsV2gsr8%3D
    • Casterline JE, Allen LH, Ruel MT. Vitamin B12 deficiency is very prevalent in lactating Guatemalan women and their infants at three months postpartum. J Nutr. 1997;127:1966-72.
    • (1997) J Nutr , vol.127 , pp. 1966-1972
    • Casterline, J.E.1    Allen, L.H.2    Ruel, M.T.3
  • 46
  • 47
    • 33845503323 scopus 로고    scopus 로고
    • Effect of folic acid supplementation on risk of cardiovascular diseases: A meta-analysis of randomized controlled trials
    • 1:CAS:528:DC%2BD28XhtlWrtrjE
    • Bazzano LA, Reynolds K, Holder KN, He J. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA. 2006;296:2720-6.
    • (2006) JAMA , vol.296 , pp. 2720-2726
    • Bazzano, L.A.1    Reynolds, K.2    Holder, K.N.3    He, J.4
  • 48
    • 77957949167 scopus 로고    scopus 로고
    • Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals
    • 1:CAS:528:DC%2BC3cXhsVSlu77N
    • Clarke R, Halsey J, Lewington S, Lonn E, Armitage J, Manson JE, et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med. 2010;170:1622-31.
    • (2010) Arch Intern Med , vol.170 , pp. 1622-1631
    • Clarke, R.1    Halsey, J.2    Lewington, S.3    Lonn, E.4    Armitage, J.5    Manson, J.E.6
  • 49
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • 1:CAS:528:DyaK2cXhvFShurw%3D
    • Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. Jama. 1993;270:2693-8.
    • (1993) Jama , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.3    Rush, D.4    Rosenberg, I.H.5
  • 50
    • 2442589571 scopus 로고    scopus 로고
    • Changes in lifestyle and plasma total homocysteine: The Hordaland Homocysteine Study
    • 1:CAS:528:DC%2BD2cXjs1ygsLc%3D
    • Nurk E, Tell GS, Vollset SE, Nygard O, Refsum H, Nilsen RM, et al. Changes in lifestyle and plasma total homocysteine: the Hordaland Homocysteine Study. Am J Clin Nutr. 2004;79:812-9.
    • (2004) Am J Clin Nutr , vol.79 , pp. 812-819
    • Nurk, E.1    Tell, G.S.2    Vollset, S.E.3    Nygard, O.4    Refsum, H.5    Nilsen, R.M.6
  • 51
    • 3042769514 scopus 로고    scopus 로고
    • Polymorphisms in the methylenetetrahydrofolate reductase and methionine synthase reductase genes and homocysteine levels in Brazilian children
    • Alessio AC, Annichino-Bizzacchi JM, Bydlowski SP, Eberlin MN, Vellasco AP, Hoehr NF. Polymorphisms in the methylenetetrahydrofolate reductase and methionine synthase reductase genes and homocysteine levels in Brazilian children. Am J Med Genet A. 2004;128A:256-60.
    • (2004) Am J Med Genet A , vol.128 , pp. 256-260
    • Alessio, A.C.1    Annichino-Bizzacchi, J.M.2    Bydlowski, S.P.3    Eberlin, M.N.4    Vellasco, A.P.5    Hoehr, N.F.6
  • 54
    • 0029094224 scopus 로고
    • Is an elevated circulating maternal homocysteine concentration a risk factor for neural tube defects?
    • 1:STN:280:DyaK28%2FptVCrtQ%3D%3D
    • Ubbink JB. Is an elevated circulating maternal homocysteine concentration a risk factor for neural tube defects? Nutr Rev. 1995;53:173-5.
    • (1995) Nutr Rev , vol.53 , pp. 173-175
    • Ubbink, J.B.1
  • 55
    • 67650354893 scopus 로고    scopus 로고
    • Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China
    • Zhang T, Xin R, Gu X, Wang F, Pei L, Lin L, et al. Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China. Public Health Nutr. 2009;12:680-6.
    • (2009) Public Health Nutr , vol.12 , pp. 680-686
    • Zhang, T.1    Xin, R.2    Gu, X.3    Wang, F.4    Pei, L.5    Lin, L.6
  • 56
    • 0032771090 scopus 로고    scopus 로고
    • Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review
    • 1:CAS:528:DyaK1MXlvFWjt7g%3D
    • Ray JG, Laskin CA. Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review. Placenta. 1999;20:519-29.
    • (1999) Placenta , vol.20 , pp. 519-529
    • Ray, J.G.1    Laskin, C.A.2
  • 57
    • 0041731989 scopus 로고    scopus 로고
    • Thulstrup AM: Lactation-A risk factor for elevated plasma homocysteine?
    • Ramlau-Hansen CH, Moller UK, Moller J. Thulstrup AM: [Lactation-a risk factor for elevated plasma homocysteine?]. Ugeskr Laeger. 2003;165:2819-23.
    • (2003) Ugeskr Laeger , vol.165 , pp. 2819-2823
    • Ramlau-Hansen, C.H.1    Moller, U.K.2    Moller, J.3
  • 58
    • 0023696435 scopus 로고
    • Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
    • 1:STN:280:DyaL1M%2FitlSqtg%3D%3D
    • Kang SS, Zhou J, Wong PW, Kowalisyn J, Strokosch G. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet. 1988;43:414-21.
    • (1988) Am J Hum Genet , vol.43 , pp. 414-421
    • Kang, S.S.1    Zhou, J.2    Wong, P.W.3    Kowalisyn, J.4    Strokosch, G.5
  • 59
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • 1:CAS:528:DyaK28XhtVyiu7s%3D
    • Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7-9.
    • (1996) Circulation , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3    Ellison, R.C.4    Eckfeldt, J.H.5    Rosenberg, I.H.6
  • 60
    • 33645652119 scopus 로고    scopus 로고
    • Prevalence of methylenetetrahydrofolate reductase 677 T and 1298C alleles and folate status: A comparative study in Mexican, West African, and European populations
    • 1:CAS:528:DC%2BD28XislSrs7k%3D
    • Gueant-Rodriguez RM, Gueant JL, Debard R, Thirion S, Hong LX, Bronowicki JP, et al. Prevalence of methylenetetrahydrofolate reductase 677 T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr. 2006;83:701-7.
    • (2006) Am J Clin Nutr , vol.83 , pp. 701-707
    • Gueant-Rodriguez, R.M.1    Gueant, J.L.2    Debard, R.3    Thirion, S.4    Hong, L.X.5    Bronowicki, J.P.6
  • 61
    • 47249164811 scopus 로고    scopus 로고
    • Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: Findings from the third National Health and Nutrition Examination Survey DNA Bank
    • 1:CAS:528:DC%2BD1cXoslyltro%3D
    • Yang QH, Botto LD, Gallagher M, Friedman JM, Sanders CL, Koontz D, et al. Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank. Am J Clin Nutr. 2008;88:232-46.
    • (2008) Am J Clin Nutr , vol.88 , pp. 232-246
    • Yang, Q.H.1    Botto, L.D.2    Gallagher, M.3    Friedman, J.M.4    Sanders, C.L.5    Koontz, D.6
  • 62
    • 33645635701 scopus 로고    scopus 로고
    • Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population
    • 1:CAS:528:DC%2BD28XislSrs7Y%3D
    • Devlin AM, Clarke R, Birks J, Evans JG, Halsted CH. Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population. Am J Clin Nutr. 2006;83:708-13.
    • (2006) Am J Clin Nutr , vol.83 , pp. 708-713
    • Devlin, A.M.1    Clarke, R.2    Birks, J.3    Evans, J.G.4    Halsted, C.H.5


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