Pain Management in the Elderly

Medical Clinics of North America

Volumn 99, Issue 2, 2015, Pages 337-350

  Malec, Monica ^a   Shega, Joseph W ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b VITAS Healthcare   (United States)

Author keywords

Older adult; Pain; Pain assessment; Pain management

Indexed keywords

ANALGESIC AGENT; BUPRENORPHINE; CAPSAICIN; CODEINE; DULOXETINE; FENTANYL; GABAPENTIN; HALOPERIDOL; HYDROCODONE; HYDROMORPHONE; LIDOCAINE; METHADONE; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; ONDANSETRON; OPIATE; OXYCODONE; PARACETAMOL; PREGABALIN; PROTON PUMP INHIBITOR; TRAMADOL; ANTICONVULSIVE AGENT; NARCOTIC ANALGESIC AGENT;

AGED; AGING; ANALGESIA; ANXIETY DISORDER; BACKACHE; CARDIOVASCULAR DISEASE; COGNITIVE DEFECT; COMORBIDITY; CONFUSION; CONSTIPATION; COPING BEHAVIOR; DIARRHEA; DIZZINESS; DROWSINESS; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG INDUCED HEADACHE; FATIGUE; FIBROMYALGIA; GASTROINTESTINAL HEMORRHAGE; HEARTBURN; HUMAN; INDIGESTION; INSOMNIA; KIDNEY FUNCTION; LIVER DYSFUNCTION; LIVER TOXICITY; LOSS OF APPETITE; LOW BACK PAIN; NAUSEA; NEUROPATHIC PAIN; OSTEOARTHRITIS; PAIN; PAIN ASSESSMENT; PAIN INTENSITY; PERIPHERAL EDEMA; PERIPHERAL NEUROPATHY; POSTHERPETIC NEURALGIA; POSTOPERATIVE PAIN; PRACTICE GUIDELINE; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; RELIGION; RESPIRATION DEPRESSION; REVIEW; SEDATION; SEROTONIN SYNDROME; SIDE EFFECT; SKIN TOXICITY; SOMNOLENCE; SWEATING; VOMITING; XEROSTOMIA; CHRONIC PAIN; CLASSIFICATION; PAIN MEASUREMENT; PROCEDURES; STANDARDS; TOPICAL DRUG ADMINISTRATION; VERY ELDERLY;

ACETAMINOPHEN; ADMINISTRATION, TOPICAL; AGED; AGED, 80 AND OVER; ANALGESICS; ANALGESICS, OPIOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICONVULSANTS; CHRONIC PAIN; HUMANS; PAIN MANAGEMENT; PAIN MEASUREMENT; PRACTICE GUIDELINES AS TOPIC;

EID: 84924958799     PISSN: 00257125     EISSN: 15579859     Source Type: Journal    
DOI: 10.1016/j.mcna.2014.11.007     Document Type: Review

References (54)

1. Shega J.W., Tiedt A., Grant K., et al. Pain measurement in the national social life, health, and aging project (NSHAP): presence, intensity, and location. JGerontol B Psychol Sci Soc Sci 2014, 69(Suppl 2):S191-S197.
2. Maxwell C.J., Dalby D.M., Slater M., et al. The prevalence and management of current daily pain among older home care clients. Pain 2008, 138(1):208-216.
3. Smith A.K., Cenzer I.S., Knight S.J., et al. The epidemiology of pain during the last 2 years of life. Ann Intern Med 2010, 153(9):563-569.
4. AGS Panel on Persistent Pain in Older Persons The management of persistent pain in older persons. JAm Geriatr Soc 2002, 50(Suppl 6):S205-S224.
5. Weiner D.K., Haggerty C.L., Kritchvesky S.B., et al. How does low back pain impact physical function in independent, well-functioning older adults? Evidence from the Health ABC Cohort and implications for the future. Pain Med 2003, 4(4):311-320.
6. Bosley B.N., Weiner D.K., Rudy T.E., et al. Is chronic nonmalignant pain associated with decreased appetite in older adults? Preliminary evidence. JAm Geriatr Soc 2004, 52:247-251.
7. Shega J.W., Dale W., Andrews M., et al. Persistent pain and frailty: a case for pain homeostenosis?. JAm Geriatr Soc 2012, 60(1):113-117.
8. Shega J.W., Andrew M., Lau D., et al. The relationship between persistent pain and 5-year mortality: a population-based, prospective cohort study. JAm Geriatr Soc 2013, 61(12):2135-2140.
9. Sawyer P., Bodner E.V., Ritchie C.S., et al. Pain and pain medication use in community-dwelling older adults. Am J Geriatr Pharmacother 2006, 4(4):316-324.
10. Won A.B., Lapane K.L., Vallow S., et al. Persistent nonmalignant pain and analgesic prescribing patterns in elderly nursing home residents. JAm Geriatr Soc 2004, 52(6):867-874.
11. Bernabei R., Gambassi G., Lapane K., et al. Management of pain in elderly patients with cancer. SAGE Study Group. Systematic Assessment of Geriatric Drug Use via Epidemiology. JAMA 1998, 279(23):1877-1882. [Erratum appears in JAMA 1999;281(2):136].
12. Herr K. Pain assessment strategies in older adults. JPain 2011, 12(3):s3-s13.
13. Herr K., Coyne P.J., Key T., et al. Pain assessment in the nonverbal patient: position statement with clinical practice recommendations. Pain Manag Nurs 2006, 7(2):44-52.
14. Trescot A.M., Helm S., Hansen H., et al. Opioids in the management of chronic noncancer pain: an update of American Society of the Interventional Pain Physicians' (ASIPP) Guidelines. Pain Physician 2008, 11(Suppl 2):S5-S62.
15. Papaleontiou M., Henderson C.R., Turner B.J., et al. Outcomes associated with opioid use in the treatment of chronic noncancer pain in older adults: a systematic review and meta-analysis. JAm Geriatr Soc 2010, 58(7):1353-1369.
16. Gilron I., Bailey J.M., Tu D., et al. Morphine, gabapentin, or their combination for neuropathic pain. NEngl J Med 2005, 352:1324-1334.
17. Rolita L., Spegman A., Tang X., et al. Greater number of narcotic analgesic prescriptions for osteoarthritis is associated with falls and fractures in elderly adults. JAm Geriatr Soc 2013, 61(3):335-340.
18. Jahr J.S., Breitmeyer J.B., Pan C., et al. Safety and efficacy of Intravenous acetaminophen in the elderly after major orthopedic surgery: subset data analysis from 3, randomized, placebo-controlled trials. Am J Ther 2012, 19(2):66-75.
19. Graham G.G., Davies M.J., Day R.O., et al. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology 2013, 21:201-232.
20. Larson A.M., Polson J., Fontana R.J., et al. Acute Liver Failure Study Group. Acetaminophen-induced acute liver failure: results of a US multicenter prospective study. Hepatology 2005, 42(6):1364-1372.
21. U.S Food and Drug Administration. FDA Drug Safety Communication: Prescription acetaminophen products to be limited to 325 mg per dosage unit; boxed warning will highlight potential for severe liver failure. January 13, 2011. Available at: . Accessed December 11, 2014. http://www.fda.gov/Drugs/DrugSafety/ucm239821.htm.
22. American Geriatrics Society Panel on the Pharmacological Management of Persistent Pain in Older Persons Pharmacological management of persistent pain in older persons. JAm Geriatr Soc 2009, 57(8):1331-1346.
23. Barkin R.L., Beckerman M., Blum S.L., et al. Should nonsteroidal anti-inflammatory drugs (NSAIDs) be prescribed to the older adult?. Drugs Aging 2010, 27(10):775-789.
24. Wallace M.B., Durlaski V.L., Vaughn J., et al. Age and alarm symptoms do not predict endoscopic findings among patients with dyspepsia: a multicenter database study. Gut 2001, 49:29-34.
25. Pilotto A., Franceschi M., Leandro G., et al. Proton pump inhibitors reduce the risk of uncomplicated peptic ulcer in the elderly either acute or chronic users of aspirin/nonsteroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2004, 20:1091-1097.
26. Pilotto A., Franceschi M., Leandro G., et al. The risk of upper gastrointestinal bleeding in the elderly users of aspirin and other nonsteroidal anti-inflammatory drugs: the role of gastroprotective drugs. Aging Clin Exp Res 2003, 15:494-499.
27. Reddy A., Yennurajalingam S., Pulivarthi K., et al. Frequency, outcome, and predictors of success within 6 weeks of an opioid rotation among outpatients with cancer receiving strong opioids. Oncologist 2013, 18:212-220.
28. Gupta D.K., Avram M.J. Rational opioid dosing in the elderly: dose and dosing intervals when initiating opioid therapy. Clin Pharmacol Ther 2012, 91(2):339-343.
29. Rauck R.L. What is the case for prescribing long-acting over short-acting opioids for patients with chronic pain? A critical review. Pain Pract 2009, 9(6):468-479.
30. Schwartz J.B. The current state of knowledge on age, sex, and their interactions on clinical pharmacology. Clin Pharmacol Ther 2007, 82(1):87-96.
31. Tumer N., Scarpace P.J., Lowenthal D.T. Geriatric pharmacology: basic and clinical considerations. Annu Rev Pharmacol Toxicol 1992, 32:271-302.
32. Davies D.F., Shock N.W. Age changes in glomerular filtration rate, effect of venal plasma flow, and tubular excretory capacity in adult males. JClin Invest 1950, 29(5):496-507.
33. Verbeeck R.K. Pharmacokinetics and dose adjustments in patients with hepatic dysfunction. Eur J Clin Pharmacol 2008, 64(12):1147-1161.
34. Murtagh F.E., Chai M.O., Donohoe P., et al. The use of opioid analgesia in end-stage renal disease patients managed without dialysis: recommendations for practice. JPain Palliat Care Pharmacother 2007, 21(2):5-16.
35. Pham P.C., Toscano E., Pham P.M., et al. Pain management in patients with chronic kidney disease. NDT Plus 2009, 2(2):111-118.
36. Dean M. Opioids in renal failure and dialysis patients. JPain Symptom Manage 2004, 28(5):497-504.
37. Lugo R.A., Satterfield K.L., Kern S.E. Pharmacokinetics of methadone. JPain Palliat Care Pharmacother 2005, 19(4):13-24.
38. Vadivelu N., Hines R.L. Management of chronic pain in the elderly: focus on transdermal buprenorphine. Clin Interv Aging 1998, 3(3):421-430.
39. Cherny N., Ripamonti C., Pereira J., et al. Strategies to manage the adverse effects of oral morphine: an evidence-based report. JClin Oncol 2001, 19(9):2542-2554.
40. Miller M., Stürmer T., Azrael D., et al. Opioid analgesics and the risk of fractures among older adults with arthritis. JAm Geriatr Soc 2011, 59(3):430-438.
41. Morrison R.S., Magaziner J., Gilbert M., et al. Relationship between pain and opioid analgesics on the development of delirium following hip fracture. JGerontol A Biol Sci Med Sci 2003, 58A(1):76-81.
42. Chou R., Fanciullo G.J., Fine P.G., et al. Opioid treatment guidelines: clinical guidelines for the use of chronic opioid therapy in chronic non-cancer pain. JPain 2009, 10(2):113-130.
43. Brown J.P., Boulay L.J. Clinical experience with duloxetine in the management of chronic musculoskeletal pain. A focus on osteoarthritis of the knee. Ther Adv Musculoskelet Dis 2013, 5(6):291-304.
44. Smith T., Nicholson R.A. Review of duloxetine in the management of diabetic peripheral neuropathic pain. Vasc Health Risk Manag 2007, 3(6):833-844.
45. Wright C.L., Mist C.D., Ross R.L., et al. Duloxetine for the treatment of fibromyalgia. Expert Rev Clin Immunol 2010, 6(5):745-756.
46. Haslam C., Nurmikko T. Pharmacological treatment of neuropathic pain in older persons. Clin Interv Aging 2008, 3(1):111-120.
47. Balmaceda C.M. Clinical trial data in support of changing guidelines in osteoarthritis treatment. JPain Res 2014, 7:211-218.
48. Derry S., Moore R.A., Rabbie R. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev 2012, (9). CD007400.
49. Derry S., Sven-Rice A., Cole P., et al. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2013, (2). CD007393.
50. Derry S., Moore R.A. Topical capsaicin (low concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2012, (9). CD010111.
51. Derry S., Wiffen P.J., Moore R.A., et al. Topical lidocaine for neuropathic pain in adults. Cochrane Database Syst Rev 2014, (7). [review], CD010958.
52. Smith H. Opioid metabolism. Mayo Clin Proc 2009, 84(7):613-624.
53. Trescot A.M., Datta S., Lee M., et al. Opioid pharmacology. Pain Physician 2008, 11(Suppl 2):S133-S153.
54. Pergolizzi J., Boger R.H., Budd K., et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, and oxycodone. Pain Pract 2008, 8(4):287-313.