Development, optimization and evaluation of long chain nanolipid carrier for hepatic delivery of silymarin through lymphatic transport pathway

International Journal of Pharmaceutics

Volumn 485, Issue 1-2, 2015, Pages 108-121

  Chaudhary, Shilpa ^a   Garg, Tarun ^a   Murthy, R S R ^a   Rath, Goutam ^a   Goyal, Amit K ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

Box Behnken design; Chylomicron; Liver target; Lymphatic system; Nanolipid carrier

Indexed keywords

CHYLOMICRON; GLYCEROL STEARATE; LIPID; NANOCARRIER; OCTANOIC ACID; OLEIC ACID; PALMITIC ACID; SILYMARIN; STEARIC ACID; DRUG CARRIER; EMULSION; GLYCEROL; NANOPARTICLE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; DRUG TRANSPORT; ELIMINATION HALF-LIFE; EVALUATION STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; LIVER; LYMPH VESSEL; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SURFACE PROPERTY; SUSPENSION; SUSTAINED DRUG RELEASE; TIME TO MAXIMUM PLASMA CONCENTRATION; X RAY ANALYSIS; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; BLOOD; CACO 2 CELL LINE; CHEMICAL PHENOMENA; CHEMISTRY; EMULSION; INTESTINE ABSORPTION; LYMPHATIC SYSTEM; MEDICINAL CHEMISTRY; METABOLIC CLEARANCE RATE; METABOLISM; NANOMEDICINE; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PROCEDURES; SOLUBILITY; STATISTICAL MODEL; TISSUE DISTRIBUTION; ULTRASOUND; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CHEMISTRY, PHARMACEUTICAL; CHYLOMICRONS; DRUG CARRIERS; EMULSIONS; FEMALE; GLYCEROL; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTESTINAL ABSORPTION; LIVER; LYMPHATIC SYSTEM; METABOLIC CLEARANCE RATE; MODELS, STATISTICAL; NANOMEDICINE; NANOPARTICLES; OLEIC ACID; PARTICLE SIZE; RATS, WISTAR; SILYMARIN; SOLUBILITY; SONICATION; TECHNOLOGY, PHARMACEUTICAL; TISSUE DISTRIBUTION;

EID: 84924955313     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.02.070     Document Type: Article

References (28)

1. A. Ali Khan, J. Mudassir, N. Mohtar, and Y. Darwis Advanced drug delivery to the lymphatic system: lipid-based nanoformulations Int. J. Nanomed. 8 2013 2733 2744
2. A. Beloqui, M.A. Solinis, A. Delgado, C. Evora, A. Isla, and A. Rodriguez-Gascon Fate of nanostructured lipid carriers (NLCs) following the oral route: design, pharmacokinetics and biodistribution J. Microencapsul. 31 2014 1 8
3. N. Borkar, D. Xia, R. Holm, Y. Gan, A. Müllertz, M. Yang, and H. Mu Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium Eur. J. Pharm. Sci. 51 2014 204 210
4. S. Chaudhary, T. Garg, R.S. Murthy, G. Rath, and A.K. Goyal Recent approaches of lipid-based delivery system for lymphatic targeting via oral route J. Drug Target. 22 10 2014 1 12
5. P. Christophersen, L. Zhang, M. Yang, H.M. Nielsen, A. Müllertz, and H. Mu Solid lipid particles for oral delivery of peptide and protein drugs I - elucidating the release mechanism of lysozyme during lipolysis Eur. J. Pharm. Biopharm. 85 2013 473 480
6. T. Garg, and A.K. Goyal Biomaterial-based scaffolds - current status and future directions Expert Opin. Drug Deliv. 11 2014 767 789
7. T. Garg, A.K. Goyal, S. Arora, and R. Murthy Development, optimization & evaluation of porous chitosan scaffold formulation of gliclazide for the treatment of type-2 diabetes mellitus Drug Deliv. Lett. 2 2012 251 261
8. T. Garg, S. Singh, and A.K. Goyal Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery Crit. Rev. Ther. Drug Carr. Syst. 30 2013 369 409
9. T. Garg, G. Rath, and A.K. Goyal Biomaterials-based nanofiber scaffold: targeted and controlled carrier for cell and drug delivery J. Drug Target. 2014 1 20
10. P. Gershkovich, and A. Hoffman Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability Eur. J. Pharm. Sci. 26 2005 394 404
11. G. Goyal, T. Garg, B. Malik, G. Chauhan, G. Rath, and A.K. Goyal Development and characterization of niosomal gel for topical delivery of benzoyl peroxide Drug Deliv. 2013 1 16
12. S.S. Hallan, P. Kaur, V. Kaur, N. Mishra, and B. Vaidya Lipid polymer hybrid as emerging tool in nanocarriers for oral drug delivery Artif. Cells Nanomed. Biotechnol. 2014 1 16
13. Y. Han, Y. Li, P. Zhang, J. Sun, X. Li, X. Sun, and F. Kong Nanostructured lipid carriers as novel drug delivery system for lung cancer gene therapy Pharm. Dev. Technol. 2015 1 5
14. D. Ibraheem, A. Elaissari, and H. Fessi Administration strategies for proteins and peptides Int. J. Pharm. 477 2014 578 589
15. L. Jia, D. Zhang, Z. Li, C. Duan, Y. Wang, F. Feng, F. Wang, Y. Liu, and Q. Zhang Nanostructured lipid carriers for parenteral delivery of silybin: biodistribution and pharmacokinetic studies Colloids Surf. B Biointerfaces 80 2010 213 218
16. A.L. Jones, and J.M. Price Some methods of electron microscopic visualization of lipoproteins in plasma and chyle J. Histochem. Cytochem. 16 1968 366 370
17. P. Kaur, T. Garg, G. Rath, R.S. Murthy, and A.K. Goyal Development, optimization and evaluation of surfactant-based pulmonary nanolipid carrier system of paclitaxel for the management of drug resistance lung cancer using Box-Behnken design Drug Deliv. 2014 1 14
18. R. Kaur, T. Garg, U. Das Gupta, P. Gupta, G. Rath, and A.K. Goyal Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs Artif. Cells Nanomed. Biotechnol. 2014 1 6
19. N.R. Manowitz, P. Tso, D.S. Drake, S. Frase, and S.M. Sabesin Dietary supplementation with Pluronic L-81 modifies hepatic secretion of very low density lipoproteins in the rat J. Lipid Res. 27 1986 196 207
20. ®): drug-lipid physicochemical interactions and characterization of drug incorporation Eur. J. Pharm. Biopharm. 68 2008 535 544
21. Y. Park, W.J. Grellner, W.S. Harris, and J.M. Miles A new method for the study of chylomicron kinetics in vivo Am. J. Physiol. Endocrinol. Metab. 279 2000 E1258 E1263
22. J. Rejman, V. Oberle, I. Zuhorn, and D. Hoekstra Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis Biochem. J. 377 2004 159 169
23. E. Roger, F. Lagarce, and J.-P. Benoit Development and characterization of a novel lipid nanocapsule formulation of Sn38 for oral administration Eur. J. Pharm. Biopharm. 79 2011 181 188
24. R. Rohilla, T. Garg, J. Bariwal, A.K. Goyal, and G. Rath Development, optimization and characterization of glycyrrhetinic acid-chitosan nanoparticles of atorvastatin for liver targeting Drug Deliv. 2014 1 8
25. W. Rubas, and G.M. Grass Gastrointestinal lymphatic absorption of peptides and proteins Adv. Drug Deliv. Rev. 7 1991 15 69
26. T. Vohra, I. Kaur, H. Heer, and R.R. Murthy Nanolipid carrier-based thermoreversible gel for localized delivery of docetaxel to breast cancer Cancer Nanotechnol. 4 2013 1 12
27. Y. Xiao, and M.R. Wiesner Characterization of surface hydrophobicity of engineered nanoparticles J. Hazard. Mater. 215-216 2012 146 151
28. N.M. Zaki, P. Artursson, and C.A. Bergstrom A modified physiological BCS for prediction of intestinal absorption in drug discovery Mol. Pharm. 7 2010 1478 1487