Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Bai, Jun ^a   Lei, Yun ^a   An, Gai Li ^a   He, Li ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; HISTONE DEACETYLASE 6; MATRIX METALLOPROTEINASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; HDAC6 PROTEIN, HUMAN; HISTONE DEACETYLASE;

A375 S2 CELL LINE; ADULT; APOPTOSIS; ARTICLE; BIOGENESIS; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL PROLIFERATION; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; MELANOMA CELL LINE; MIDDLE AGED; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; UPREGULATION; WESTERN BLOTTING; CELL AGING; CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; MELANOMA; METABOLISM; MITOCHONDRION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR STEM CELL ASSAY;

APOPTOSIS; CELL AGING; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HISTONE DEACETYLASES; HUMANS; MATRIX METALLOPROTEINASES; MELANOMA; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR STEM CELL ASSAY;

EID: 84924943825     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0121247     Document Type: Article

References (27)

1. Grozinger CM, Hassig CA, Schreiber SL. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A. 1999;96:4868-4873. PMID: 10220385
2. Boyault C, Sadoul K, Pabion M, Khochbin S. HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene. 2007;26:5468-5476. PMID: 17694087
3. De Ruijter AJ, Van Gennip AH, Caron HN, Kemp S, Van Kuilenburg AB. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J. 2003;370:737-749. PMID: 12429021
4. Kang J, Pervaiz S. Mitochondria: redox metabolism and dysfunction. Biochem Res Int. 2012;2012:896751. doi: 10.1155/2012/896751 PMID: 22593827
5. Yoboue ED, Devin A. Reactive oxygen species-mediated control of mitochondrial biogenesis. Int J Cell Biol. 2012;2012:403870. doi: 10.1155/2012/403870 PMID: 22693510
6. Ling YH, Liebes L, Zou YY, Perez-Soler R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 nonsmall cell lung cancer cells. J Biol Chem. 2003;278:33714-33723. PMID: 12821677
7. Paradies G, Petrosillo G, Pistolese M, Ruggiero FM. Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage. Gene. 2002;286:135-141. PMID: 11943469
8. Marija K, Larisa PM. The pole of apoptosis in psoriasis and lichen planus. In: Cho DW (Ed), Focus on Cell Apoptosis Research. 2007;233-240.
9. Liu MJ, Wang Z, Li HX, Wu RC, Liu YZ, Wu QY, et al. Mitochondrial dysfunction as an early event in the process of apoptosis induced by woodfordin I in human leukemia K562 cells. Toxicol Appl Pharm. 2004;194:141-155. PMID: 14736495
10. Kamemura K, Ogawa M, Ohkubo S, Ohtsuka Y, Shitara Y, Komiya T, et al. Depression of mitochondrial metabolism by downregulation of cytoplasmic deacetylase, HDAC6. Febs Lett. 2012;586:1379-1383. doi: 10.1016/j.febslet.2012.03.060 PMID: 22504143
11. Aldana-Masangkay GI, Sakamoto KM. The role of HDAC6 in cancer. J Biomed Biotechnol. 2011;2011:875824. doi: 10.1155/2011/875824 PMID: 21076528
12. Park C. Histone deacetylases 1, 6 and 8 are critical for invasion in breast cancer. Oncol Rep. 2011;25(6):1677-1681. doi: 10.3892/or.2011.1236 PMID: 21455583
13. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, et al. R-alpha-Lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. Diab tologia. 2008;51:165-174.
14. Zuckerman JE, Hsueh T, Koya RC, Davis ME, Ribas A. siRNA knockdown of ribonucleotide reductase inhibits melanoma cell line proliferation alone or synergistically with temozolomide. J Invest Dermatol. 2011;131:453-460. doi: 10.1038/jid.2010.310 PMID: 20944646
15. Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell. 2002;109(3):335-346. PMID: 12015983
16. Huang SH, Wu LW, Huang AC, Yu CC, Lien JC, Huang YP, et al. Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375. S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways. J Agric Food Chem. 2012;60:665-675. doi: 10.1021/jf204193v PMID: 22148415
17. Ventura-Clapier R, Garnier A, Veksler V. Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 alpha. Cardiovasc Res. 2008;79:208-217. doi: 10.1093/cvr/cvn098 PMID: 18430751
18. Bo H, Zhang Y, Ji LL. Redefining the role of mitochondria in exercise: a dynamic remodeling. Ann N Y Acad Sci. 2010;1201:121-128. doi: 10.1111/j.1749-6632.2010.05618.x PMID: 20649548
19. Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science. 2004;305:626-629. PMID: 15286356
20. Kaufmann SH, Earnshaw WC. Induction of apoptosis by cancer chemotherapy. Exp Cell Res. 2000;256:42-49. PMID: 10739650
21. Adams JM, Cory S. The Bcl-2 protein family: Arbiters of cell survival. Science. 1998;281:1322-1326. PMID: 9735050
22. Czabotar PE, Lessene G, Strasser A, Adams JM. Control of apoptosis by the Bcl-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Bio. 2014;15:49-63. doi: 10.1038/nrm3722 PMID: 24355989
23. Jiang XJ, Wang XD. Cytochrome C-mediated apoptosis. Annu Rev Biochem. 2004;73:87-106. PMID: 15189137
24. Ma YF, Zhang J, Zhang Q, Chen P, Song JY, Yu SJ, et al. Adenosine induces apoptosis in human liver cancer cells through ROS production and mitochondrial dysfunction. Biochem Biophys Res Commun. 2014;448:8-14. doi: 10.1016/j.bbrc.2014.04.007 PMID: 24727456
25. Yoon DH, Lim MH, Lee YR, Sung GH, Lee TH, Jeon BH, et al. A novel synthetic analog of militarin, MA-1 induces mitochondrial dependent apoptosis by ROS generation in human lung cancer cells. Toxicol Appl Pharmacol. 2013;273:659-671. doi: 10.1016/j.taap. 2013.10.015 PMID: 24161344
26. Lee W, Kim KY, Yu SN, Kim SH, Chun SS, Ji JH, et al. Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells. Biochem Biophys Res Commun. 2013;430:406-412. doi: 10.1016/j.bbrc.2012.11.030 PMID: 23159637
27. Petrosillo G, Ruggiero FM, Paradies G. Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria. FASEB J. 2003;17:2202-2208. PMID: 14656982