Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis

Journal of Biological Chemistry

Volumn 290, Issue 11, 2015, Pages 6705-6713

  Zhao, Hong ^a   Chiaro, Christopher R ^a   Zhang, Limin ^a,c   Smith, Philip B ^a   Chan, Chung Yu ^b   Pedley, Anthony M ^a   Pugh, Raymond J ^a   French, Jarrod B ^d   Patterson, Andrew D ^a   Benkovic, Stephen J ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b The Pennsylvania State University   (United States)

^c Wuhan National Laboratory for Optoelectronics   (China)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CYTOLOGY; ENZYMES; MOBILE SECURITY; NUCLEOTIDES;

BIOSYNTHESIS PATHWAYS; CELLULAR LEVELS; CULTURE MEDIUM; FLUX RATES; INOSINE MONOPHOSPHATE DEHYDROGENASE; METABOLOMICS; PURINE NUCLEOTIDES; SYNTHETIC ENZYMES;

BIOSYNTHESIS;

ADENYLOSUCCINATE SYNTHASE; INOSINATE DEHYDROGENASE; MULTIENZYME COMPLEX; PURINE NUCLEOTIDE; PURINOSOME; UNCLASSIFIED DRUG; 2-DIMETHYLAMINO-4,5,6,7-TETRABROMO-1H-BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; LIGASE; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHETASE; PURINE; PURINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DIFFUSION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; HUMAN CELL; METABOLOMICS; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PURINE SYNTHESIS; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; STEADY STATE; ELECTROSPRAY MASS SPECTROMETRY; HELA CELL LINE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES;

ADENYLOSUCCINATE SYNTHASE; BENZIMIDAZOLES; CARBON-NITROGEN LIGASES WITH GLUTAMINE AS AMIDE-N-DONOR; HELA CELLS; HUMANS; IMP DEHYDROGENASE; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS; MULTIENZYME COMPLEXES; PURINE NUCLEOTIDES; PURINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84924943411     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.628701     Document Type: Article

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