Enzyme clustering accelerates processing of intermediates through metabolic channeling

Nature Biotechnology

Volumn 32, Issue 10, 2014, Pages 1011-1018

  Castellana, Michele ^a   Wilson, Maxwell Z ^a   Xu, Yifan ^a   Joshi, Preeti ^a   Cristea, Ileana M ^a   Rabinowitz, Joshua D ^a   Gitai, Zemer ^a   Wingreen, Ned S ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; EFFICIENCY; ESCHERICHIA COLI; MAMMALS; METABOLISM; SIZE SEPARATION;

EFFICIENCY BENEFITS; EFFICIENCY IMPROVEMENT; ENZYME ACTIVE SITES; METABOLIC CHANNELING; METABOLIC REGULATIONS; QUANTITATIVE FRAMEWORKS; QUANTITATIVE MODELING; STEADY STATE FLUXES;

ENZYMES;

ARGININE; BACTERIAL ENZYME; ENZYME; ESCHERICHIA COLI PROTEIN; PYRIMIDINE; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL METABOLISM; CLUSTER ANALYSIS; CONCEPTUAL FRAMEWORK; ENZYME ACTIVE SITE; ENZYME LOCALIZATION; ENZYME METABOLISM; ENZYME REGULATION; ESCHERICHIA COLI; LIQUID CHROMATOGRAPHY; MATHEMATICAL MODEL; METABOLIC REGULATION; MICHAELIS MENTEN KINETICS; NONHUMAN; PLASMID; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STEADY STATE; BIOLOGICAL MODEL; BIOLOGY; ENZYMOLOGY; HOMEOSTASIS; METABOLISM; PHYSIOLOGY;

ESCHERICHIA COLI; MAMMALIA;

ARGININE; COMPUTATIONAL BIOLOGY; ENZYMES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HOMEOSTASIS; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; PYRIMIDINES;

EID: 84917699113     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3018     Document Type: Article

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